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14 条记录 (耗时 0.017 秒)

    Antibody that specifically binds an Mch4 polypeptide
    1.
    发明授权
    Antibody that specifically binds an Mch4 polypeptide 有权
    特异性结合Mch4多肽的抗体

    公开(公告)号：US06730779B2

    公开(公告)日：2004-05-04

    申请号：US09952768

    申请日：2001-09-10

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C07K1600

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    Antibody that specifically binds an Mch5 polypeptide
    2.
    发明授权
    Antibody that specifically binds an Mch5 polypeptide 失效
    特异性结合Mch5多肽的抗体

    公开(公告)号：US06897296B2

    公开(公告)日：2005-05-24

    申请号：US10668955

    申请日：2003-09-22

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/64 ,  C12N15/57 ,  C07K16/00

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    Apoptotic protease Mch6, nucleic acids encoding same and methods of use
    6.
    发明授权
    Apoptotic protease Mch6, nucleic acids encoding same and methods of use 失效
    凋亡蛋白酶Mch6，编码相同的核酸和使用方法

    公开(公告)号：US06455296B2

    公开(公告)日：2002-09-24

    申请号：US08865579

    申请日：1997-05-29

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack

    IPC分类号： C12N964

    CPC分类号： C12N9/6475 ,  C07K16/40

    摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.

    摘要翻译： 本发明提供编码Mch6的分离基因及其功能片段。 还提供了编码Mch6的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch6核苷酸序列的编码链或非编码链的单链或双链核酸。 本发明还提供了分离的Mch6多肽和分离的Mch6多肽的大和小亚基，包括其功能片段。

    MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use
    8.
    发明授权
    MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use 失效
    MCH4和MCH5，凋亡蛋白酶，核酸编码和使用方法

    公开(公告)号：US5786173A

    公开(公告)日：1998-07-28

    申请号：US665220

    申请日：1996-06-14

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/64 ,  C12N15/57 ,  C12P21/06 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。 基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

    Mch4 and Mch5, apoptotic protease, nucleic acids encoding and methods of use
    10.
    发明授权
    Mch4 and Mch5, apoptotic protease, nucleic acids encoding and methods of use 有权
    Mch4和Mch5，凋亡蛋白酶，核酸编码和使用方法

    公开(公告)号：US06287795B1

    公开(公告)日：2001-09-11

    申请号：US09291692

    申请日：1999-04-13

    申请人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    发明人： Emad S. Alnemri ,  Teresa Fernandes-Alnemri ,  Gerald Litwack ,  Robert Armstrong ,  Kevin Tomaselli

    IPC分类号： C12Q137

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

    摘要翻译： 本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。 还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。所述基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。 还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。 还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。