发明申请
US20060084613A1 Inhibitors of the ICE/ced-3 family of cysteine proteases
审中-公开
ICE / ced-3家族半胱氨酸蛋白酶抑制剂
- 专利标题： Inhibitors of the ICE/ced-3 family of cysteine proteases
- 专利标题（中）： ICE / ced-3家族半胱氨酸蛋白酶抑制剂
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申请号： US11241857申请日： 2005-09-30
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公开(公告)号： US20060084613A1公开(公告)日： 2006-04-20
- 发明人: Robert Ternansky , Patricia Gladstone , Kevin Tomaselli , Bin Chao , Steven Linton
- 申请人： Robert Ternansky , Patricia Gladstone , Kevin Tomaselli , Bin Chao , Steven Linton
- 申请人地址： US CA San Diego 92121
- 专利权人： Idun Pharmaceuticals, Inc.
- 当前专利权人： Idun Pharmaceuticals, Inc.
- 当前专利权人地址： US CA San Diego 92121
- 主分类号： A61K38/06
- IPC分类号： A61K38/06 ; C07K5/06
摘要：
This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
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