公开(公告)号：US11357833B2

公开(公告)日：2022-06-14

申请号：US15760416

申请日：2016-09-16

Applicant: ContraFect Corporation

Inventor： Michael Wittekind ,  Raymond Schuch

IPC: A61K38/47 ,  A61K38/12 ,  A61K45/06 ,  A61K9/00 ,  A61K31/7036 ,  A61K38/46 ,  A61K38/16 ,  A61P31/04 ,  C12N9/36

Abstract: The present disclosure relates to methods for restoring or augmenting bactericidal activity of an antibiotic in an organ or tissue in which pulmonary surfactant is present. More specifically, the present disclosure describes that inhibition of antibiotics due to environmental factors, such as the presence of pulmonary surfactant in an organ or tissue such as the respiratory epithelium can be sidestepped or overcome and the effectiveness of the antibiotic in that milieu restored or augmented by co-administration of an antibiotic and a lysin.

公开(公告)号：US20200054749A1

公开(公告)日：2020-02-20

申请号：US16674149

申请日：2019-11-05

Applicant: CONTRAFECT CORPORATION ,  TRELLIS BIOSCIENCE, LLC

Inventor： Angeles Estelles ,  Lawrence M. Kauvar ,  Adam Vigil ,  Michael Wittekind

IPC: A61K39/42 ,  C07K16/10

Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.

公开(公告)号：US09889181B2

公开(公告)日：2018-02-13

申请号：US13909618

申请日：2013-06-04

Applicant: CONTRAFECT CORPORATION

Inventor： Raymond Schuch ,  Robert C. Nowinski ,  Michael Wittekind ,  Han Lee ,  Brent Schneider

IPC: A61K38/46 ,  A61K38/14 ,  A61K38/12 ,  A61K38/47

CPC classification number: A61K38/46 ,  A61K31/4188 ,  A61K31/5377 ,  A61K38/12 ,  A61K38/14 ,  A61K38/47 ,  A61K45/06 ,  C12N9/503 ,  C12Y302/01017 ,  A61K2300/00

Abstract: The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

公开(公告)号：US09718875B2

公开(公告)日：2017-08-01

申请号：US15268091

申请日：2016-09-16

Applicant: ContraFect Corporation

Inventor： Michael Wittekind ,  Adam Vigil

IPC: C12N7/00 ,  C07K16/10 ,  A61K9/00 ,  A61K39/42 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/1018 ,  A61K9/0043 ,  A61K9/007 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly neutralizing antibodies or active fragments thereof, directly to the respiratory tract, including by intranasal or inhalation administration. The invention provides compositions suitable for intranasal or inhalation treatment and administration. The invention includes methods for treatment or prophylaxis combining intranasal or inhalation administration with intraperitoneal or intravenous administration of antibodies.

公开(公告)号：US20170189529A1

公开(公告)日：2017-07-06

申请号：US15116106

申请日：2015-02-04

Applicant: CONTRAFECT CORPORATION ,  TRELLIS BIOSCIENCE, LLC

Inventor： Angeles Estelles ,  Lawrence M. Kauvar ,  Adam Vigil ,  Michael Wittekind

IPC: A61K39/42 ,  C07K16/10

CPC classification number: A61K39/42 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/543 ,  C07K16/1018 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.

公开(公告)号：US09499594B2

公开(公告)日：2016-11-22

申请号：US14399588

申请日：2013-05-09

Applicant: CONTRAFECT CORPORATION

Inventor： Raymond Schuch ,  Robert C. Nowinski ,  Michael Wittekind ,  Babar Khan ,  Jimmy Rotolo

IPC: A61K38/16 ,  C07K14/315 ,  A61P31/04 ,  A01N63/00 ,  C12N9/50 ,  A61L29/08 ,  A61L29/16

CPC classification number: A01N63/00 ,  A61K38/16 ,  A61K38/164 ,  A61K38/47 ,  A61K45/06 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2420/00 ,  C07K14/315 ,  C12N9/503 ,  C12Y302/01017

Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

Abstract translation: 本发明提供了用赖素，特别是具有杀死葡萄球菌细菌（包括耐药性金黄色葡萄球菌，特别是赖氨酸PlySs2）的能力的赖氨酸来预防，控制，破坏和治疗细菌生物膜的方法。 本发明还提供了用于治疗或调节细菌生物膜和生物膜形成的组合物和方法。