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公开(公告)号：US20190339499A1
公开(公告)日：2019-11-07
申请号：US16511046
申请日：2019-07-15
Applicant: Bioptigen, Inc.
Inventor： Christopher Saxer , AI-Hafeez Z. Dhalla , Robert H. Hart , Eric L. Buckland
IPC: G02B21/00 , G02B27/00 , G02B21/08 , A61B3/12 , A61B3/10 , G02B7/00 , G02B21/22 , G02B5/00 , G02B21/06 , G02B21/02
Abstract: Surgical microscopes are provided including at least one ocular, an objective lens; a collimated space between the at least one ocular and the objective lens; an illumination system optically coupled into the collimated space of the surgical microscope, wherein an illumination from the illumination system is directed along a path at least partially contained within the collimated space of the surgical microscope and through the objective lens; and one of a field diaphragm and obscuration mask positioned within the illumination system, and outside of a field of view of the at least one ocular, wherein the one of the field diaphragm and the obscuration mask blocks, attenuates or diverts rays from the illumination system that reflect from a surface of the objective lens such that the reflected rays are not visible through the at least one ocular.
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公开(公告)号：US10271725B2
公开(公告)日：2019-04-30
申请号：US15826966
申请日：2017-11-30
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Andrew Murnan , Nestor O. Farmiga , Robert H. Hart , Christopher Saxer
Abstract: Optical coherence tomography (OCT) imaging systems are provided including a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. The beam shaping optical assembly includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.
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公开(公告)号：US09498121B2
公开(公告)日：2016-11-22
申请号：US14745980
申请日：2015-06-22
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Nestor O. Farmiga , Robert H. Hart , Andrew Murnan , Christopher Saxer
IPC: A61B3/14 , A61B3/00 , A61B3/10 , G01B9/02 , A61B3/13 , G02B21/00 , G02B21/02 , G02B27/00 , G02B27/09 , G02B27/14 , A61B5/00 , G02B1/11
CPC classification number: A61B3/102 , A61B3/13 , A61B3/132 , A61B5/0066 , G01B9/02039 , G01B9/02091 , G02B1/11 , G02B21/0012 , G02B21/0048 , G02B21/006 , G02B21/02 , G02B21/025 , G02B27/0031 , G02B27/0955 , G02B27/141
Abstract: Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
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14.发明申请Surgical Microscopes Using Optical Coherence Tomography and Related Systems 审中-公开手术显微镜使用光学相干断层扫描和相关系统公开(公告)号：US20150305618A1
公开(公告)日：2015-10-29
申请号：US14745980
申请日：2015-06-22
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Nestor O. Farmiga , Robert H. Hart , Andrew Murnan , Christopher Saxer
CPC classification number: A61B3/102 , A61B3/13 , A61B3/132 , A61B5/0066 , G01B9/02039 , G01B9/02091 , G02B1/11 , G02B21/0012 , G02B21/0048 , G02B21/006 , G02B21/02 , G02B21/025 , G02B27/0031 , G02B27/0955 , G02B27/141
Abstract: Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
Abstract translation: 本发明构思的一些实施例提供了用于与显微镜集成的光学相干断层摄影（OCT）系统。 OCT系统包括耦合到显微镜的成像路径的样品臂。 所述采样臂包括输入光束变焦组件，其包括至少两个可移动透镜，所述可移动透镜被配置为提供OCT信号光束的形状控制 扫描组件，其包括至少一个扫描镜并被配置为用于远心扫描所述OCT信号光束; 以及光束扩展器，其被配置为设置入射在显微镜物镜上的OCT信号光束直径。 形状控制包括成像OCT束的数值孔径和焦点位置的可分离控制。
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15.发明申请OPTICAL COHERENCE TOMOGRAPHY FOR PRECISION METROLOGY AND RELATED SYSTEMS AND METHODS 有权光学相干计量学与相关系统与方法的光学相干计算公开(公告)号：US20150168250A1
公开(公告)日：2015-06-18
申请号：US14573339
申请日：2014-12-17
Applicant: Bioptigen, Inc.
Inventor： Christopher Saxer , Robert H. Hart , Eric L. Buckland
CPC classification number: G01M11/0207 , A61B5/0066 , G01B9/02044 , G01B9/02064 , G01B9/02072 , G01B9/02091 , G01M11/025 , G01M11/0271
Abstract: An optical coherence tomography (OCT) measurement system for precision measurement of a translucent sample is provided. The system includes an optical coherence tomography (OCT) imaging system comprising a broadband light source, a reference path with reference path length, and sample path with a beam scanning assembly and an imaging lens assembly; a sample positioning assembly including an immersion bath for positioning the translucent sample within an immersion bath; a position assembly for locating the translucent sample within a field of view (FOV) of the OCT imaging system; an immersion lens assembly associated with the imaging lens assembly configured to eliminate an air to bath refractive interface between a distal surface of the OCT imaging lens including an immersion tip and a surface of the bath; a first set of calibration parameters that relate a position of a scanning beam at an imaging plane to drive signals of the scanning assembly; and a second set of calibration parameters for relating an optical path length or optical path length variation of the scanning beam at an imaging plane to the position of the scanning beam or to the drive signals of the scanning assembly.
Abstract translation: 提供了一种用于精确测量半透明样品的光学相干断层扫描（OCT）测量系统。 该系统包括光学相干断层摄影（OCT）成像系统，其包括宽带光源，具有参考路径长度的参考路径以及具有光束扫描组件和成像透镜组件的采样路径; 样品定位组件，其包括用于将半透明样品定位在浸浴中的浸浴; 用于将所述半透明样品定位在所述OCT成像系统的视场（FOV）内的位置组件; 与所述成像透镜组件相关联的浸没透镜组件被配置为消除在包括浸没末端和所述浴表面的所述OCT成像透镜的远侧表面之间的空气至浴的折射界面; 第一组校准参数，其将扫描光束在成像平面处的位置与扫描组件的驱动信号相关联; 以及用于将扫描光束在成像平面处的光程长度或光程长度变化与扫描光束的位置或扫描组件的驱动信号相关联的第二组校准参数。
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Patent Agency Ranking
16.发明授权公开(公告)号：US10048057B2
公开(公告)日：2018-08-14
申请号：US15190299
申请日：2016-06-23
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Al-Hafeez Z. Dhalla , Nestor O. Farmiga , Mehran Ghofrani , Robert H. Hart , Andrew Murnan , Christopher Saxer
Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.
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公开(公告)号：US09949634B2
公开(公告)日：2018-04-24
申请号：US14295664
申请日：2014-06-04
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Andrew Murnan , Nestor O. Farmiga , Robert H. Hart , Christopher Saxer
CPC classification number: A61B3/102 , A61B3/1025 , G01B9/02038 , G01B9/02042 , G01B9/02091 , G02B19/0014 , G02B23/2407
Abstract: Optical coherence tomography (OCT) imaging systems are provided including a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. The beam shaping optical assembly includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.
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公开(公告)号：US09733152B2
公开(公告)日：2017-08-15
申请号：US14573339
申请日：2014-12-17
Applicant: Bioptigen, Inc.
Inventor： Christopher Saxer , Robert H. Hart , Eric L. Buckland
CPC classification number: G01M11/0207 , A61B5/0066 , G01B9/02044 , G01B9/02064 , G01B9/02072 , G01B9/02091 , G01M11/025 , G01M11/0271
Abstract: An optical coherence tomography (OCT) measurement system for precision measurement of a translucent sample is provided. The system includes an optical coherence tomography (OCT) imaging system comprising a broadband light source, a reference path with reference path length, and sample path with a beam scanning assembly and an imaging lens assembly; a sample positioning assembly including an immersion bath for positioning the translucent sample within an immersion bath; a position assembly for locating the translucent sample within a field of view (FOV) of the OCT imaging system; an immersion lens assembly associated with the imaging lens assembly configured to eliminate an air to bath refractive interface between a distal surface of the OCT imaging lens including an immersion tip and a surface of the bath; a first set of calibration parameters that relate a position of a scanning beam at an imaging plane to drive signals of the scanning assembly; and a second set of calibration parameters for relating an optical path length or optical path length variation of the scanning beam at an imaging plane to the position of the scanning beam or to the drive signals of the scanning assembly.
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19.发明申请公开(公告)号：US20160360961A1
公开(公告)日：2016-12-15
申请号：US15246578
申请日：2016-08-25
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Nestor O. Farmiga , Robert H. Hart , Andrew Murnan , Christopher Saxer
CPC classification number: A61B3/102 , A61B3/13 , A61B3/132 , A61B5/0066 , G01B9/02039 , G01B9/02091 , G02B1/11 , G02B21/0012 , G02B21/0048 , G02B21/006 , G02B21/02 , G02B21/025 , G02B27/0031 , G02B27/0955 , G02B27/141
Abstract: Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.
Abstract translation: 本发明构思的一些实施例提供了用于与显微镜集成的光学相干断层摄影（OCT）系统。 OCT系统包括耦合到显微镜的成像路径的样品臂。 所述采样臂包括输入光束变焦组件，其包括至少两个可移动透镜，所述可移动透镜被配置为提供OCT信号光束的形状控制 扫描组件，其包括至少一个扫描镜并被配置为用于远心扫描所述OCT信号光束; 以及光束扩展器，其被配置为设置入射在显微镜物镜上的OCT信号光束直径。 形状控制包括成像OCT束的数值孔径和焦点位置的可分离控制。
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20.发明授权Image registration, averaging, and compounding for high speed extended depth optical coherence tomography 有权高速扩展深度光学相干断层扫描的图像配准，平均和复合公开(公告)号：US09377291B2
公开(公告)日：2016-06-28
申请号：US14561772
申请日：2014-12-05
Applicant: Bioptigen, Inc.
Inventor： Eric L. Buckland , Al-Hafeez Z. Dhalla , Nestor O. Farmiga , Mehran Ghofrani , Robert H. Hart , Andrew Murnan , Christopher Saxer
CPC classification number: G01B9/02087 , A61B3/102 , G01B9/02004 , G01B9/02028 , G01B9/02044 , G01B9/02091
Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditioned wavelength dependent interferogram; and computes a first A-scan from the first wavelength dependent interferogram; a second A-scan from the second wavelength dependent interferogram; a spatial offset between the first and second A-scans derived from the multiplicative product of the preconditioned first and second wavelength dependent interferograms; and a combined A-scan from the first and second A-scans.
Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括一个光学开关，用于在具有第一参考光路长度的第一参考反射器的第一路径和第二参考反射器之间切换参考路径，第二路径具有第二参考光路长度，第二参考反射器不同于第一参考 光路长度。 该系统还包括一个光束组合器，它将来自采样通路中的被摄体反射的源辐射与在第一时间间隔期间从第一参考反射器返回的源辐射和第二时间间隔内的第二参考反射器混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预先规定第一和第二波长依赖干涉图; 第一预处理波长依赖干涉图和第二预处理波长依赖干涉图的倍数; 并从第一波长依赖干涉图计算第一A扫描; 来自第二波长依赖性干涉图的第二A扫描; 从预处理的第一和第二波长相关干涉图的乘积产生的第一和第二A-扫描之间的空间偏移; 以及来自第一和第二A扫描的组合的A扫描。
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