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公开(公告)号：US20210155969A1
公开(公告)日：2021-05-27
申请号：US16920276
申请日：2020-07-02
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
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Patent Agency Ranking
12.发明申请公开(公告)号：US20200340029A1
公开(公告)日：2020-10-29
申请号：US16926926
申请日：2020-07-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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13.发明授权公开(公告)号：US10767146B2
公开(公告)日：2020-09-08
申请号：US15031958
申请日：2014-10-24
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Eric Ursprung , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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公开(公告)号：US10472662B2
公开(公告)日：2019-11-12
申请号：US15829746
申请日：2017-12-01
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
IPC: C12Q1/06 , C12Q1/04 , G01N33/569
Abstract: Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in a dried form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target).
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15.发明申请公开(公告)号：US20180087084A1
公开(公告)日：2018-03-29
申请号：US15829746
申请日：2017-12-01
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
IPC: C12Q1/04 , G01N33/569
CPC classification number: C12Q1/04 , G01N33/56911
Abstract: Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in a dried form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target).
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公开(公告)号：US20160138076A1
公开(公告)日：2016-05-19
申请号：US14745722
申请日：2015-06-22
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
IPC: C12Q1/34
CPC classification number: C12Q1/34 , C12Q1/04 , G01N2333/986
Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
Abstract translation: 本文提供了用于检测特异性β-内酰胺酶的方法和组合物，包括A类丝氨酸碳青霉烯酶，金属-β-内酰胺酶，AmpCβ-内酰胺酶和广谱β-内酰胺酶（ESBL）。 本文提供的方法包括允许在少至2至10分钟内检测细菌样品中特定β-内酰胺酶的存在的方法。
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