-
11.发明申请公开(公告)号：US20180169099A1
公开(公告)日：2018-06-21
申请号：US15670874
申请日：2017-08-07
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Leivers , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
IPC: A61K31/517 , C07D413/12 , C07D409/14 , C07D409/12 , C07D239/70 , C07D405/12 , C07D403/12 , C07D401/12 , C07D407/12
CPC classification number: A61K31/517 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
-
12.发明申请公开(公告)号：US20150051217A1
公开(公告)日：2015-02-19
申请号：US14473336
申请日：2014-08-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
IPC: C07D239/70
CPC classification number: C07D239/70
Abstract: The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了包含式I的化合物及其药学上可接受的盐：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
-
公开(公告)号：US10124069B2
公开(公告)日：2018-11-13
申请号：US15182429
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： Ho Huat Lee , Moana Tercel , John A. Flygare , Janet Gunzner-Toste , Thomas H. Pillow , Brian Safina , Leanna Staben , Vishal Verma , BinQing Wei , Guiling Zhao
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
-
公开(公告)号：US09550775B2
公开(公告)日：2017-01-24
申请号：US14772735
申请日：2014-03-14
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Paul Robert Bichler , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Brian Safina , Tao Sheng , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D401/14 , A61K31/437 , C07D471/04 , C07D519/00 , C07D471/08
CPC classification number: C07D471/04 , C07D471/08 , C07D519/00
Abstract: The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有以下通式的化合物：[插入式（I）]（I）及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，R1，R2，R3 ，R4和RN具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
-
公开(公告)号：US08933236B2
公开(公告)日：2015-01-13
申请号：US13899469
申请日：2013-05-21
Applicant: Genentech, Inc. , Xenon Pharmaceuticals Inc.
Inventor： Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Daniel Ortwine , Brian Safina , Shaoyi Sun , Daniel P. Sutherlin , Alla Yurevna Zenova
IPC: C07C311/51 , C07D403/12 , C07D213/82 , C07D213/64 , C07D205/04 , C07D311/58 , A61K31/445 , A61K31/44 , A61K31/18 , C07D265/30 , C07D233/84 , C07D257/04 , C07C307/06 , C07D295/26 , C07D207/48 , C07D311/70 , C07D413/12 , C07D451/02 , C07D307/12 , C07D309/08 , C07D311/72 , C07D405/12 , C07D491/107 , C07D211/22 , C07D295/192 , C07D211/96 , C07D307/18
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有以下通式的新化合物及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，B，R1，R2，R3，R4，R5和RN具有 本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
-
Patent Agency Ranking
公开(公告)号：US20130317001A1
公开(公告)日：2013-11-28
申请号：US13899526
申请日：2013-05-21
Applicant: XENON PHARMACEUTICALS INC. , GENENTECH, INC.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D403/12 , C07D213/64 , C07D205/04 , C07D311/58 , C07D295/26 , C07D233/84 , C07D257/04 , C07C311/51 , C07C307/06 , C07D213/82 , C07D265/30
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
![PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE](/abs-image/US/2013/08/29/US20130225557A1/abs.jpg.150x150.jpg)
17.发明申请PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE 失效吡咯并[3,2-d]吡嗪PI3K DELTA抑制剂化合物及其使用方法公开(公告)号：US20130225557A1
公开(公告)日：2013-08-29
申请号：US13854635
申请日：2013-04-01
Applicant: Genentech, Inc.
Inventor： Georgette Castanedo , Bryan Chan , Matthew C. Lucas , Brian Safina , Daniel P. Sutherlin , Zachary Sweeney
IPC: C07D471/04 , C07D491/107
CPC classification number: C07D471/04 , C07D491/107
Abstract: Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Abstract translation: 式I化合物，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学障碍和癌症介导的病症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
-
公开(公告)号：US10533058B2
公开(公告)日：2020-01-14
申请号：US15104388
申请日：2014-12-16
Applicant: GENENTECH INC. , MEDIMMUNE LIMITED
Inventor： John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben , Philip Wilson Howard , Luke Masterson
IPC: A61K47/68 , A61K31/5517 , C07K16/30 , C07K16/28
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
-
公开(公告)号：US20190083643A1
公开(公告)日：2019-03-21
申请号：US16150623
申请日：2018-10-03
Applicant: Genentech, Inc.
Inventor： Ho Huat Lee , Moana Tercel , John A. Flygare , Janet Gunzner-Toste , Thomas H. Pillow , Brian Safina , Leanna Staben , Vishal Verma , BinQing Wei , Guiling Zhao
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
-
公开(公告)号：US09546164B2
公开(公告)日：2017-01-17
申请号：US14603273
申请日：2015-01-22
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Paul Robert Bichler , Chien-An Chen , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Tao Sheng , Shaoyi Sun , Andrew D. White , Michael Scott Wilson , Alla Yurevna Zenova , Jiuxiang Zhu
IPC: C07D211/32 , C07D211/54 , C07D233/68 , C07D453/02 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/495 , C07D237/08 , C07D241/04 , C07D205/04 , C07D207/12 , C07D211/42 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D403/04 , C07D487/08 , C07D265/30 , C07D211/60
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有通式I的化合物及其药学上可接受的盐，其中变量RA，RAA，下标n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN 具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
-
-
-
-
-
-
-
-
-
Search Results
41
records
(took 0.052 seconds)
