-
公开(公告)号：US11203572B2
公开(公告)日：2021-12-21
申请号：US17011355
申请日：2020-09-03
发明人： Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Steven McKerrall , Daniel Sutherlin
IPC分类号： C07C381/10 , C07D401/12 , C07D205/04 , C07D211/22 , C07D211/42 , C07D213/69 , A61P25/04
摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US09546164B2
公开(公告)日：2017-01-17
申请号：US14603273
申请日：2015-01-22
发明人： Jean-Christophe Andrez , Paul Robert Bichler , Chien-An Chen , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Tao Sheng , Shaoyi Sun , Andrew D. White , Michael Scott Wilson , Alla Yurevna Zenova , Jiuxiang Zhu
IPC分类号： C07D211/32 , C07D211/54 , C07D233/68 , C07D453/02 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/495 , C07D237/08 , C07D241/04 , C07D205/04 , C07D207/12 , C07D211/42 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D403/04 , C07D487/08 , C07D265/30 , C07D211/60
CPC分类号： A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译： 本发明提供具有通式I的化合物及其药学上可接受的盐，其中变量RA，RAA，下标n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN 具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
-
公开(公告)号：US10457654B2
公开(公告)日：2019-10-29
申请号：US15799771
申请日：2017-10-31
发明人： Daniel Sutherlin , Steven McKerrall , Michael Scott Wilson , Kwong Wah Lai , Philippe Bergeron , Birong Zhang , Ramsay Beveridge , Jean-Philippe Leclerc , Alexandre Lemire , Liang Zhao , Claudio Sturino
IPC分类号： C07D285/08 , C07D277/52 , C07D239/69 , C07D213/76 , C07D261/16 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/427 , A61P19/02 , A61P29/00
摘要： The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1—Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US10179767B2
公开(公告)日：2019-01-15
申请号：US15161085
申请日：2016-05-20
发明人： Sultan Chowdhury , Christoph Martin Dehnhardt , Abid Hasan , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Shaoyi Sun , Andrew D. White , Wei Gong , Alla Yurevna Zenova , Jiuxiang Zhu
IPC分类号： A01N43/00 , A61K31/00 , C07D211/22 , C07D211/48 , C07D211/34 , C07D405/08 , C07D401/12 , C07D401/08 , C07D211/42 , C07D221/20 , C07D401/04 , C07D211/38 , C07D211/62
摘要： The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US11130726B2
公开(公告)日：2021-09-28
申请号：US16685335
申请日：2019-11-15
IPC分类号： C07C62/38 , C07C62/34 , C07C229/48 , C07D211/22 , C07C317/44 , C07C323/61 , C07C69/757 , A61P25/00 , A61P29/00 , A61P17/04 , C07C313/04
摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US10787446B2
公开(公告)日：2020-09-29
申请号：US15939112
申请日：2018-03-28
发明人： Philippe Bergeron , Kristen Burford , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Abid Hasan , Kwong Wah Lai , Zhiguo Liu , Steven McKerrall , Teresa Phuongtram Nguyen , Brian Safina , Daniel Sutherlin , Tao Wang
IPC分类号： C07D405/14 , C07D417/12 , C07D417/14 , A61P17/04 , C07D401/12 , C07D491/107
摘要： The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US10766858B2
公开(公告)日：2020-09-08
申请号：US16088417
申请日：2017-03-28
发明人： Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Steven McKerrall , Daniel Sutherlin
IPC分类号： C07C381/10 , C07D401/12 , C07D205/04 , C07D211/22 , C07D211/42 , C07D213/69 , A61P25/04
摘要： The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US09694002B2
公开(公告)日：2017-07-04
申请号：US15275131
申请日：2016-09-23
发明人： Jean-Christophe Andrez , Paul Robert Bichler , Chien-An Chen , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Zhiguo Liu , Daniel F. Ortwine , Brian Safina , Daniel Sutherlin , Tao Sheng , Shaoyi Sun , Andrew D. White , Michael Scott Wilson , Alla Yurevna Zenova , Jiuxiang Zhu
IPC分类号： C07D211/32 , C07D211/54 , C07D233/68 , A61K31/445 , A61K31/4545 , A61K31/4523
CPC分类号： A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
-
公开(公告)号：US11028075B2
公开(公告)日：2021-06-08
申请号：US16283451
申请日：2019-02-22
申请人： GENENTECH, INC.
发明人： Daniel Sutherlin , Steven McKerrall , Kwong Wah Lai , Zhiguo Liu , Wenfeng Liu , Ramsay Beveridge , Jean-Philippe Leclerc , Alexandre Lemire , Liang Zhao , Claudio Sturino
IPC分类号： C07D413/12 , C07D403/12 , C07D233/96 , C07D401/12 , A61P17/04 , C07D263/52 , C07D305/06 , C07D401/14 , A61K31/506 , A61K31/538 , C07B59/00 , A61K31/63 , A61K45/06 , C07D239/69 , A61K31/505
摘要： The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:
-
10.发明授权公开(公告)号：US10793550B2
公开(公告)日：2020-10-06
申请号：US16495802
申请日：2018-03-22
申请人： GENENTECH, INC.
IPC分类号： C07D401/14 , C07D405/14 , A61P9/00 , A61P11/00 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/24
摘要： The invention provides 4-piperidin-chroman-7-sulfonamide derivatives and salts thereof that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.037 秒)
