Abstract:
Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.
Abstract:
A system and method for managing inertial torque reaction of a powertrain include a selectively engageable counter-rotating component to reduce or eliminate torque reaction on stationary powertrain structure. Selectively engageable counter-rotating inertia may be provided by a simple inertial mass or by an electrical machine functioning as an integral starter/generator (ISG) to provide vehicle launch assist, regenerative braking of the vehicle, and engine cranking. Embodiments include gear-driven, chain-driven, and belt-driven counter-rotating inertias selectively coupled for counter-rotation relative to the crankshaft by a clutch, a belt-driven pulley assembly, or chain-driven intermediate shaft assembly with a hydraulically actuated coupling pin.
Abstract:
A system and method for managing inertial torque reactions on stationary powertrain structure rotate at least one selected engine component and at least one selected drive train component in opposite directions so the rotational inertia of the selected drive train component acts in a direction opposite to that of the rotational inertia of the selected engine component to reduce or eliminate the inertial torque reactions on stationary powertrain structure caused by rotational acceleration and deceleration of powertrain components and improves performance with respect to noise, vibration, and harshness (NVH).
Abstract:
Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of structured lipid compositions containing sciadonic and/or pinoleic acid alone or in combination with other bioactive fatty acids including, but not limited to, eicosapentaenoic acid, docosahexaenoic acid, conjugated linoleic acid, and non-β-oxidizable fatty acid analogues such as tetradecylthioacetic acid.
Abstract:
The invention provides lipid compositions comprising phospholipids having a high docosahexaenoic acid (DHA) content, which compositions are preferably extracted from natural sources. The lipid compositions are excellent sources of highly bioavailable DHA and they can be used in oral delivery vehicles, dietary supplements, functional foods, and the like.
Abstract:
The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
Abstract:
The invention concerns fatty acids uninterrupted by a methylene group as anti-inflammatory agents in superficial tissues of mammals, more particularly a pharmaceutical or cosmetic topical composition comprising, as an active ingredient, at least one fatty acid uninterrupted by a methylene group corresponding to formula (I), an salt or ester thereof, wherein R1 is a C1-C5 alkyl group and R2 is a C2-C6 alkyl group. Preferably, the fatty acid uninterrupted by a methylene group is 20:3(5,11,14). The fatty acid uninterrupted by a methylene group is also used for preparing a composition for modulating the metabolism of lipids in the superficial tissue of mammals.
Abstract:
Autoimmune diseases are controlled by the administration of non-methylene interrupted fatty acids of the formula ##STR1## in which R is alkyl or alkenyl. A preferred compound within the scope of this formula is 5,11,14-eicosatrienoic acid.
Abstract:
The present invention relates to the use of erythritol for the up regulation of the SOD2 enzyme in mammals and prevention or treatment of hypertension. More specifically, erythritol protects against the development of endothelial dysfunction and related reduction of vasodilatation and erythritol protects against hemolysis-induced vasoconstriction.
Abstract:
A vehicle powertrain including a multiple cylinder internal combustion engine and a controllable transmission controls engine shutdown by shutting off a fuel supply device or devices such as a fuel pump or fuel injector(s) while the transmission is in gear to load the engine and reduce or eliminate engine run-on. The transmission may be controlled to couple the input shaft to a stationary component or simultaneously engage clutches corresponding to different gear ratios to provide a holding torque on the engine.