公开(公告)号：US20150030227A1

公开(公告)日：2015-01-29

申请号：US14376177

申请日：2013-02-01

申请人： The Research Foundation of The State University of New York

发明人： Zhengrong Liang ,  Jianhua Ma ,  Yan Liu

IPC分类号： G06T11/00 ,  A61B6/03

CPC分类号： G06T11/005 ,  A61B6/032 ,  G06T11/006 ,  G06T2207/10081 ,  G06T2207/10124 ,  G06T2207/30096 ,  G06T2211/424

摘要： Provided herein is a computerized image reconstruction apparatus and method that includes recording projection path information and energy loss information of a plurality of particles traversing an object being imaged and determining an estimated image of the object based on the projection path information and the energy loss information sampled into a projection format. The estimated image includes an active volume defined by an enclosure border. Cost function minimization uses an Adaptive-weighted Total Variation cost function, a Penalized Weighted Least-Squares cost function, or an Alpha-Divergence cost function to update the estimated image. An iterative updating algorithm corresponding to the cost function updates the estimated image and produces a final image based on the estimated image according to a predetermined threshold.

摘要翻译： 本文提供了一种计算机图像重建装置和方法，其包括记录穿过正在成像的对象的多个粒子的投影路径信息和能量损失信息，并且基于投影路径信息和采样的能量损失信息来确定对象的估计图像 成为投影格式。 估计的图像包括由外壳边界定义的活动卷。 成本函数最小化使用自适应加权总变差成本函数，惩罚加权最小二乘法成本函数或Alpha-Divergence代价函数来更新估计图像。 对应于成本函数的迭代更新算法更新估计图像，并根据预定阈值基于估计图像产生最终图像。

公开(公告)号：US08700938B2

公开(公告)日：2014-04-15

申请号：US13666097

申请日：2012-11-01

申请人： The Research Foundation of the State University of New York

发明人： Kanad Ghose

IPC分类号： G06F1/32

CPC分类号： G06F1/3203 ,  G06F1/3287 ,  G06F9/3802 ,  G06F9/3814 ,  G06F9/3836 ,  G06F9/384 ,  G06F9/3869 ,  G06F9/5027 ,  G06F9/5094 ,  Y02D10/171 ,  Y02D10/22

摘要： There is provided a system and methods for segmenting datapath resources such as reorder buffers, physical registers, instruction queues and load-store queues, etc. in a microprocessor so that their size may be dynamically expanded and contracted. This is accomplished by allocating and deallocating individual resource units to each resource based on sampled estimates of the instantaneous resource needs of the program running on the microprocessor. By keeping unused datapath resources to a minimum, power and energy savings are achieved by shutting off resource units that are not needed for sustaining the performance requirements of the running program. Leakage energy and switching energy and power are reduced using the described methods.

摘要翻译： 提供了一种用于在微处理器中分割数据路径资源（例如重新排序缓冲器，物理寄存器，指令队列和加载存储队列等）的系统和方法，使得它们的大小可以被动态地扩展和收缩。 这是通过基于在微处理器上运行的程序的瞬时资源需求的采样估计来分配和释放各个资源单元到每个资源来实现的。 通过将未使用的数据路径资源保持在最低限度，通过关闭维护正在运行的程序的性能要求所不需要的资源单元来实现功率和能量节省。 使用所描述的方法减少了泄漏能量和开关能量和功率。

公开(公告)号：US20130165824A1

公开(公告)日：2013-06-27

申请号：US13768710

申请日：2013-02-15

申请人： University of Illinois ,  The Research Foundation of the State University of New York

发明人： Clinton Rubin ,  Stefan Judex ,  Timothy J. Koh

IPC分类号： A61H1/00

CPC分类号： A61H1/00 ,  A61H1/005 ,  A61H23/02 ,  A61H23/0218 ,  A61H23/0245 ,  A61H2033/0029 ,  A61H2201/0153 ,  A61H2201/0157 ,  A61H2201/1623 ,  A61H2201/1628 ,  A61H2201/164 ,  A61H2203/03 ,  A61H2203/0406 ,  A61H2203/0412 ,  A61H2203/0425 ,  A61H2203/0443 ,  A61H2205/081 ,  A61H2205/083 ,  A61H2205/108 ,  A61H2230/30 ,  A61H2230/70 ,  A61N2/02 ,  A63B21/00196 ,  A63B21/4037 ,  A63B2213/004

摘要： Methods and systems of applying physical stimuli to tissue are disclosed. The methods can include reducing or suppressing pancreatitis in a subject by administering a low magnitude, high frequency mechanical signal on a period basis and for a time sufficient to reduce or suppress pancreatitis. The methods can include enhancing healing of damaged tissue in a subject by administering to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to treat the damaged tissue. The systems can include a device for generating a low magnitude, high frequency physical signal and a platform for applying the low magnitude, high frequency physical signal to the subject for a predetermined time.

摘要翻译： 公开了将物理刺激应用于组织的方法和系统。 所述方法可以包括通过在周期基础上施用低量级的高频机械信号和足以减少或抑制胰腺炎的时间来减少或抑制受试者的胰腺炎。 所述方法可以包括通过向患者施用周期性基础上的低幅度，高频机械信号和足以治疗受损组织的时间来增强受试者中受损组织的愈合。 该系统可以包括用于产生低幅度，高频物理信号的装置和用于在预定时间内向对象施加低幅度高频物理信号的平台。

公开(公告)号：US20210346502A1

公开(公告)日：2021-11-11

申请号：US17284434

申请日：2019-10-10

申请人： Tambo, Inc. ,  The Research Foundation of the State University of New York

发明人： Jose M. Mejia Oneto ,  Nathan Yee ,  Jochem Theodoor Van Herpt ,  Chun-Min Zeng ,  Da-Ming Gou ,  Maksim Royzen

IPC分类号： A61K47/14 ,  A61K31/704 ,  A61K38/07 ,  A61K38/14 ,  A61K38/15 ,  C07C51/47 ,  C07C67/327 ,  C07C62/32 ,  C07C62/30 ,  C07D207/46 ,  C07D493/08

摘要： The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.

公开(公告)号：US20160279046A1

公开(公告)日：2016-09-29

申请号：US15173092

申请日：2016-06-03

申请人： The Research Foundation of The State University of New York

发明人： Marie A. Badalemente ,  Alexander B. Dagum

IPC分类号： A61K8/66 ,  A61Q19/06

CPC分类号： A61K8/66 ,  A61K38/4886 ,  A61K2800/30 ,  A61K2800/91 ,  A61Q19/06

摘要： The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenase septa network in the skin that comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenase septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cellulite of the skin.

摘要翻译： 本发明涉及胶原酶注射在包含脂肪团的皮肤中溶解和裂解胶原酶隔膜网络的发现。 因此，本发明涉及在需要这种治疗的患者中治疗脂肪团的方法，包括将有效量的纯化胶原酶注射或以其他方式递送到皮肤中脂肪团的胶原酶隔膜网络。 本发明还涉及胶原酶在制备治疗皮肤脂肪团的药物中的用途。

公开(公告)号：US20020182267A1

公开(公告)日：2002-12-05

申请号：US10179312

申请日：2002-06-24

申请人： The Research Foundation of the State University of New York at Stony Brook

发明人： Israel Kleinberg ,  Milroy Codipilly

IPC分类号： A61K033/40 ,  A61K033/32 ,  A61K033/14 ,  A61K031/315

CPC分类号： A61Q11/00 ,  A61K8/20 ,  A61K8/22 ,  A61K8/27 ,  A61K8/49 ,  A61K31/54 ,  A61K33/14 ,  A61K33/30 ,  A61K33/40 ,  A61K2800/88 ,  Y10S514/90 ,  Y10S514/901 ,  Y10S514/902 ,  A61K2300/00

摘要： The present invention relates to an oral composition containing a zinc compound containing free available zinc ion and at least one stabilized or stable Eh raising compound distributed in an oral vehicle. The present invention further relates to a method of inhibiting the formation of sulfur containing anions and preventing a reduction in the Eh of the oral cavity. A method of reducing oral malodor and gingivitis and periodontitis is also provided by this invention.

公开(公告)号：US20180236111A1

公开(公告)日：2018-08-23

申请号：US15961554

申请日：2018-04-24

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services ,  The Research Foundation of the State University of New York

发明人： Peter R. Williamson ,  Dale O. Kiesewetter ,  John Panepinto ,  Jin Qiu

IPC分类号： A61K51/04 ,  C07D251/68 ,  C07B59/00 ,  A61K31/53

CPC分类号： A61K51/0461 ,  A61K31/53 ,  C07B59/002 ,  C07D251/68

摘要： Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R2 is —NHC(O)—R3-L or —C(O)NH—R3-L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]AlF, 64Cu, 68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

公开(公告)号：US09921251B2

公开(公告)日：2018-03-20

申请号：US14185298

申请日：2014-02-20

申请人： Bird Technologies Group Inc. ,  The Research Foundation of the State University of New York

发明人： Joel D. Meltzer ,  Albert H. Titus ,  Bilel Neji ,  Jing Xu

IPC分类号： G01R21/02 ,  G01K17/08

CPC分类号： G01R21/02 ,  G01K17/08

摘要： Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.

公开(公告)号：US20140239940A1

公开(公告)日：2014-08-28

申请号：US14185298

申请日：2014-02-20

申请人： The Research Foundation of the State University of New York ,  Bird Technologies Group Inc.

发明人： Joel D. Meltzer ,  Albert H. Titus ,  Bilel Neji ,  Jing Xu

IPC分类号： G01R21/02

CPC分类号： G01R21/02 ,  G01K17/08

摘要： Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.

摘要翻译： 公开了一种具有电耦合到RF输入的负载的射频（RF）功率量热计，电耦合到负载并被配置为向负载施加低频偏置的可变低频电源。 RF功率量热计包括热耦合到负载的热介质。 此外，RF功率量热计包括热耦合到热介质的出口温度传感器，出口温度传感器被定位成通过负载加热来测量热介质的温度。 RF功率量热计还具有电路，其被配置为使用与RF负载热接触的热介质的温度测量结合低频偏置来测量与RF输入电耦合的RF源的平均功率。 还在使用RF功率量热计测量RF功率的方法中公开。

公开(公告)号：US20130204613A1

公开(公告)日：2013-08-08

申请号：US13832584

申请日：2013-03-15

申请人： The Research Foundation of the State University of New York

发明人： Namrata GODBOLE ,  Steven Skiena ,  Manjunath Srinivasaiah

IPC分类号： G06F17/21

CPC分类号： G06F17/21 ,  G06F17/279

摘要： A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.

摘要翻译： 用于确定与实体相关联的情绪的方法包括输入与该实体相关联的多个文本，将多个文本中的种子字标注为正或负，基于标签确定多个单词的分数估计， 列举所述多个单词的路径并确定情绪交替的数量，使用只有多个交替数在阈值内的路径来确定所述多个单词的最终得分，将所述最终分数转换为所述多个单词中的每一个的相应z分数 的字，并输出与该实体相关联的情绪。