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公开(公告)号：US10168365B2
公开(公告)日：2019-01-01
申请号：US14769798
申请日：2014-02-20
发明人： Joel D. Meltzer , Albert H. Titus , Bilel Neji , Jing Xu
摘要： Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.
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公开(公告)号：US09891251B2
公开(公告)日：2018-02-13
申请号：US14185298
申请日：2014-02-20
发明人： Joel D. Meltzer , Albert H. Titus , Bilel Neji , Jing Xu
摘要： Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.
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公开(公告)号：US20160369271A1
公开(公告)日：2016-12-22
申请号：US15022748
申请日：2014-09-17
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2310/531 , C12Q1/6876 , C12Q2600/178
摘要： Disclosed are RNA constructs which function to bind and/or inhibit a non-coding RNA (e.g., a miRNA). Such RNA constructs include an optionally weakened stem-loop structure stabilized by binding to a non-coding RNA. The non-coding RNA preferentially binds to the RNA construct as compared to a natural target (e.g., a mRNA). In certain embodiments, the RNA construct inhibits the function of the non-coding RNA. Such RNA constructs also have three-way junction joining regions 3′ and 5′ of the stem-loop structure.
摘要翻译： 公开了用于结合和/或抑制非编码RNA（例如miRNA）的RNA构建体。 这样的RNA构建体包括通过结合非编码RNA稳定的任选弱化的茎 - 环结构。 与天然靶标（例如mRNA）相比，非编码RNA优先与RNA构建体结合。 在某些实施方案中，RNA构建体抑制非编码RNA的功能。 这样的RNA构建体也具有茎 - 环结构的三通连接区域3'和5'。
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4.发明申请SMALL MOLECULE IMAGING OF FUNGI BY POSITRON EMISSION TOMOGRAPHY SCANNING 审中-公开通过POSITRON排放测量扫描进行真菌小分子成像公开(公告)号：US20160287729A1
公开(公告)日：2016-10-06
申请号：US15030554
申请日：2014-10-23
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV , THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK
IPC分类号： A61K51/04 , C07D251/68 , C07B59/00
CPC分类号： A61K51/0461 , A61K31/53 , C07B59/002 , C07D251/68
摘要： Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl ; R2 is —NHC(O)—R3—L or —C(O)NH—R3—L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]AlF, 64Cu, 68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).
摘要翻译： 其中R1是胺，羟基，硫化物，羧酸，酰胺，烷基或芳基; R2是-NHC（O）-R3-L或-C（O）NH-R3-L，其中R3是芳基或脂族基团（例如烷基）; 每个R 4独立地可以选自卤素，脂族（例如烷基），芳基，胺，羟基，卤代烷基，羧酸，酰胺，芳烷基，氰基，酯，硫醇，硫醚或烷氧基; 每个R 5独立地可以选自氢，芳烷基，烷基或芳基，任意一个芳烷基，烷基或芳基任选被提供给R 4的任何取代基取代; 每个n独立地为1,2,3,4或5; L为18F或能够螯合放射性标记的螯合剂（例如[18F] AlF，64Cu，68Ga）的螯合剂，1,4,7,10-四氮杂环十二烷四乙酸（DOTA）或1,4,7-三氮杂环壬烷 - 三乙酸（NOTA）。
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公开(公告)号：US20160025783A1
公开(公告)日：2016-01-28
申请号：US14769798
申请日：2014-02-20
发明人： Joel D. Meltzer , Albert H. Titus , Bilel Neji , Jing Xu
IPC分类号： G01R21/02
摘要： Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.
摘要翻译： 公开了一种具有电耦合到RF输入的负载的射频（RF）功率量热计，电耦合到负载并被配置为向负载施加低频偏置的可变低频电源。 RF功率量热计包括热耦合到负载的热介质。 此外，RF功率量热计包括热耦合到热介质的出口温度传感器，出口温度传感器被定位成通过负载加热来测量热介质的温度。 RF功率量热计还具有电路，其被配置为使用与RF负载热接触的热介质的温度测量结合低频偏置来测量与RF输入电耦合的RF源的平均功率。 还在使用RF功率量热计测量RF功率的方法中公开。
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公开(公告)号：US20040184907A1
公开(公告)日：2004-09-23
申请号：US10765807
申请日：2004-01-27
IPC分类号： F03D001/00
CPC分类号： B01D53/34 , A61L9/00 , A61L9/16 , A62D2203/10 , B01D53/885 , B01D2257/91 , F24F3/16
摘要： An improved method of altering a fluid-borne contaminant includes the steps of: providing a pump (21) having an inlet (22) and an outlet (23); connecting the pump inlet to a source (24) of contaminated fluid; operating the pump at a pressure ratio of at least 2.0 so as to sufficiently elevate the temperature of the fluid and contaminants passing through the pump, or, alternatively, operating the pump so that the outlet temperature of the fluid and contaminants passing therethrough is at least about 200null C.; and controlling the time during which the temperature of the fluid and contaminants are elevated; thereby to alter or convert substantially all of the contaminants passing through the pump.
摘要翻译： 改进流体污染物的改进方法包括以下步骤：提供具有入口（22）和出口（23）的泵（21）; 将泵入口连接到受污染流体的源（24）; 以至少2.0的压力比操作泵，以便充分提高通过泵的流体和污染物的温度，或者替代地操作泵，使得流过其的流体和污染物的出口温度至少为 约200℃。 并控制流体和污染物的温度升高的时间; 从而基本上改变或转换通过泵的所有污染物。
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公开(公告)号：US11305000B2
公开(公告)日：2022-04-19
申请号：US15875479
申请日：2018-01-19
申请人： THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK , BAXALTA INCORPORATED , BAXALTA GMBH , BROOKHAVEN SCIENCE ASSOCIATES, LLC
发明人： Brian A. Crowe , Ian Livey , Maria O'Rourke , Michael Schwendinger , John J. Dunn , Benjamin J. Luft
摘要： The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
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公开(公告)号：US09968693B2
公开(公告)日：2018-05-15
申请号：US15030554
申请日：2014-10-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Research Foundation of the State University of New York
IPC分类号： C07D251/68 , A61K31/53 , A61K51/04 , A61P31/10 , C07B59/00
CPC分类号： A61K51/0461 , A61K31/53 , C07B59/002 , C07D251/68
摘要： Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R2 is —NHC(O)—R3—L or —C(O)NH—R3—L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]AlF, 64Cu, 68Ga),1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).
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公开(公告)号：US09251606B2
公开(公告)日：2016-02-02
申请号：US14376177
申请日：2013-02-01
发明人： Zhengrong Liang , Jianhua Ma , Yan Liu
CPC分类号： G06T11/005 , A61B6/032 , G06T11/006 , G06T2207/10081 , G06T2207/10124 , G06T2207/30096 , G06T2211/424
摘要： Provided herein is a computerized image reconstruction apparatus and method that includes recording projection path information and energy loss information of a plurality of particles traversing an object being imaged and determining an estimated image of the object based on the projection path information and the energy loss information sampled into a projection format. The estimated image includes an active volume defined by an enclosure border. Cost function minimization uses an Adaptive-weighted Total Variation cost function, a Penalized Weighted Least-Squares cost function, or an Alpha-Divergence cost function to update the estimated image. An iterative updating algorithm corresponding to the cost function updates the estimated image and produces a final image based on the estimated image according to a predetermined threshold.
摘要翻译： 本文提供了一种计算机图像重建装置和方法，其包括记录穿过正在成像的对象的多个粒子的投影路径信息和能量损失信息，并且基于投影路径信息和采样的能量损失信息来确定对象的估计图像 成为投影格式。 估计的图像包括由外壳边界定义的活动卷。 成本函数最小化使用自适应加权总变差成本函数，惩罚加权最小二乘法成本函数或Alpha-Divergence代价函数来更新估计图像。 对应于成本函数的迭代更新算法更新估计图像，并根据预定阈值基于估计图像产生最终图像。
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10.发明申请公开(公告)号：US20140214722A1
公开(公告)日：2014-07-31
申请号：US14163674
申请日：2014-01-24
发明人： JAMES GLIMM , Jimmie Goode , Beiyu Lin , Nicholas Pezolano , Svetlozar Rachev
IPC分类号： G06Q40/06
CPC分类号： G06Q40/06
摘要： A computer-implemented method for forecasting losses in a financial portfolio includes estimating parameters of an autoregressive-moving-average generalized-autoregressive-conditional-heteroscedastic (ARMA-GARCH) model for each individual asset in a financial portfolio by performing a parallel maximum likelihood estimation, estimating parameters of a copula dependence structure for standardized residuals of the ARMA-GARCH model, and estimating a Value-at-Risk (VaR) for the financial portfolio from the ARMA-GARCH model parameters and the copula dependence structure parameters.
摘要翻译： 用于预测金融投资组合中的损失的计算机实现方法包括通过执行并行最大似然估计来估计金融投资组合中的每个单独资产的自回归移动平均广义自回归 - 条件异方差（ARMA-GARCH）模型的参数 ，估计ARMA-GARCH模型标准化残差的Copula依赖结构参数，并根据ARMA-GARCH模型参数和Copula依赖结构参数估计金融投资组合中的风险价值（VaR）。
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