公开(公告)号：US5811520A

公开(公告)日：1998-09-22

申请号：US919706

申请日：1997-08-29

Applicant: Phillip R. Hawkins ,  Lynn E. Murry

Inventor： Phillip R. Hawkins ,  Lynn E. Murry

IPC: G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/68 ,  C07K1/00

CPC classification number: C12Q1/6876 ,  C07K14/4703 ,  A61K38/00 ,  C12Q2600/158

Abstract: The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.

Abstract translation: 本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。 本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。 另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。 本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

公开(公告)号：US5712115A

公开(公告)日：1998-01-27

申请号：US618164

申请日：1996-03-19

Applicant: Phillip R. Hawkins ,  Scott Michael Braxton ,  Lynn E. Murry

Inventor： Phillip R. Hawkins ,  Scott Michael Braxton ,  Lynn E. Murry

IPC: C12N15/02 ,  A61K31/00 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  A61P37/02 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  C07H21/04 ,  C12N15/00 ,  C12N15/63

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: The present invention provides a polynucleotide which identifies and encodes a human cell death-associated protein (cdap) which was isolated from a rheumatoid synovium library. The invention provides for genetically engineered expression vectors and host cells comprising a nucleic acid sequence encoding CDAP. The invention also provides for the therapeutic use of purified CDAP, cdap or its antisense molecules, or CDAP inhibitors in pharmaceutical compositions and for treatment of conditions or diseases associated with expression of CDAP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.

Abstract translation: 本发明提供鉴定和编码从类风湿滑膜文库中分离的人细胞死亡相关蛋白（cdap）的多核苷酸。 本发明提供了基因工程表达载体和宿主细胞，其包含编码CDAP的核酸序列。 本发明还提供了药物组合物中纯化的CDAP，cdap或其反义分子或CDAP抑制剂的治疗用途以及用于治疗与CDAP表达相关的病症或疾病。 本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

公开(公告)号：US5650280A

公开(公告)日：1997-07-22

申请号：US409373

申请日：1995-03-23

Applicant: Susan G. Stuart ,  Phillip R. Hawkins ,  Jeffrey J. Seilhamer

Inventor： Susan G. Stuart ,  Phillip R. Hawkins ,  Jeffrey J. Seilhamer

IPC: G01N33/566 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cb, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for the detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.

Abstract translation: 本发明提供了鉴定和编码新型纤维连翘蛋白（cb）的核苷酸和氨基酸序列。 本发明还提供编码cb的核苷酸序列的反义分子，用于产生纯化的CB的表达载体，能够特异性结合CB的抗体，用于检测CB编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程 用于表达CB的宿主细胞，基于编码CB的核酸分子和能够特异性结合CB的抗体的活化的，发炎的或患病的细胞和/或组织的诊断测试。

公开(公告)号：US5587301A

公开(公告)日：1996-12-24

申请号：US402217

申请日：1995-03-10

Applicant: Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

Inventor： Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

IPC: G01N33/566 ,  C07K14/705 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C12N5/10

CPC classification number: C07K14/705

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for the detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.

Abstract translation: 本发明提供鉴定和编码人脐静脉内皮细胞的透明质酸受体（hr）的核苷酸和氨基酸序列。 本发明还提供编码hr的核苷酸序列的反义分子，用于产生纯化的HR的表达载体，能够特异性结合HR的抗体，用于检测HR编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程 用于表达HR的宿主细胞，基于编码HR的核酸分子和能够特异性结合受体的抗体的活化的，血管生成的，发炎的或转移性细胞和/或组织的诊断测试。

公开(公告)号：US08008027B2

公开(公告)日：2011-08-30

申请号：US12730953

申请日：2010-03-24

Applicant: Karl J. Guegler ,  Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

Inventor： Karl J. Guegler ,  Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

IPC: G01N33/53 ,  G01N33/567

CPC classification number: C07K14/522 ,  A61K38/00 ,  C12Q1/6883 ,  C12Q2600/158 ,  Y10S514/885 ,  Y10S930/14

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

Abstract translation: 本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。 本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主 用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

公开(公告)号：US06677126B2

公开(公告)日：2004-01-13

申请号：US10096703

申请日：2002-03-12

Applicant: Jennifer L. Hillman ,  Phillip R. Hawkins

Inventor： Jennifer L. Hillman ,  Phillip R. Hawkins

IPC: G01N3353

CPC classification number: C07K14/4702 ,  A61K38/00

Abstract: The invention provides a human translational regulator (TRANAC) and polynucleotides which identify and encode TRANAC. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of TRANAC.

Abstract translation: 本发明提供了人翻译调节子（TRANAC）和识别和编码TRANAC的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与TRANAC表达相关的疾病的方法。

公开(公告)号：US06486300B1

公开(公告)日：2002-11-26

申请号：US09460532

申请日：1999-12-13

Applicant: Olga Bandman ,  Phillip R. Hawkins

Inventor： Olga Bandman ,  Phillip R. Hawkins

IPC: C07K1700

CPC classification number: C12N9/12 ,  A61K38/00

Abstract: The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.

Abstract translation: 本发明提供鉴定和编码新型人类nm23样蛋白（H-nm23）的多核苷酸。 本发明提供了遗传工程改造的表达载体和宿主细胞，其包含编码H-nm23的核酸序列和用于产生蛋白质的方法。 本发明还提供使用基本上纯化的H-nm23用于治疗与H-nm23表达相关的疾病。 本发明还描述了利用包含与编码H-nm23的天然存在的序列和特异性结合蛋白的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

公开(公告)号：US06281333B1

公开(公告)日：2001-08-28

申请号：US09212146

申请日：1998-12-15

Applicant: Phillip R. Hawkins ,  Olga Bandman

Inventor： Phillip R. Hawkins ,  Olga Bandman

IPC: C07K100

CPC classification number: C07K14/4726

Abstract: The present invention provides a polynucleotide which identifies and encodes a novel human galectin-8. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human galectin-8. The invention also provides for the production and use of substantially purified human galectin-8 in pharmaceutical compositions to increase immune responses. The invention also provides for the use of antisense molecules and antibodies in pharmaceutical compositions to decrease immune response. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding human galectin-8 and anti-human galectin-8 antibodies which specifically bind to human galectin-8.

Abstract translation: 本发明提供鉴定和编码新型人半乳凝素-8的多核苷酸。 本发明提供了包含编码人半乳凝素-8的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供在药物组合物中生产和使用基本纯化的人半乳凝素-8以增加免疫应答。 本发明还提供在药物组合物中使用反义分子和抗体来降低免疫应答。 本发明还描述了利用多核苷酸与编码人galectin-8和特异性结合人galectin-8的抗人galectin-8抗体的转录物和/或基因组DNA杂交的诊断测定法。

公开(公告)号：US6071701A

公开(公告)日：2000-06-06

申请号：US203235

申请日：1998-12-01

Applicant: Karl J. Guegler ,  Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

Inventor： Karl J. Guegler ,  Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

IPC: C12N15/09 ,  A61K38/00 ,  A61P9/00 ,  A61P43/00 ,  C07K14/52 ,  C07K14/54 ,  C07K16/24 ,  C12N15/19 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19

CPC classification number: C07K14/522 ,  C12Q1/6883 ,  A61K38/00 ,  C12Q2600/158 ,  Y10S514/885 ,  Y10S930/14

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization robes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

Abstract translation: 本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。 本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测ADEC编码核苷酸序列的杂交长袍或寡核苷酸，遗传工程化宿主 用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

公开(公告)号：US6060239A

公开(公告)日：2000-05-09

申请号：US621018

申请日：1996-03-22

Applicant: Susan G. Stuart ,  Phillip R. Hawkins ,  Jeffrey J. Seilhamer ,  Lynn E. Murry

Inventor： Susan G. Stuart ,  Phillip R. Hawkins ,  Jeffrey J. Seilhamer ,  Lynn E. Murry

IPC: G01N33/566 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C07H21/04 ,  C12N15/00 ,  C12N15/63 ,  C12N15/85

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.