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    Antibodies to a chemokine expressed in inflamed adenoid
    1.
    发明授权
    Antibodies to a chemokine expressed in inflamed adenoid 失效
    在发炎腺样体中表达的趋化因子的抗体

    公开(公告)号：US07235239B2

    公开(公告)日：2007-06-26

    申请号：US10700314

    申请日：2003-10-28

    Applicant: Karl J Guegler ,  Phillip R Hawkins ,  Craig G Wilde, deceased ,  Jeffrey J Seilhamer, deceased

    Inventor： Karl J Guegler ,  Phillip R Hawkins ,  Craig G Wilde, deceased ,  Jeffrey J Seilhamer, deceased

    IPC: A61K39/395 ,  C07K16/24

    CPC classification number: C07K14/522 ,  A61K38/00 ,  C12Q1/6883 ,  C12Q2600/158

    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

    Abstract translation: 本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。 本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主 用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

    Human selenium-binding protein
    3.
    发明授权
    Human selenium-binding protein 失效
    人硒结合蛋白

    公开(公告)号：US06312895B1

    公开(公告)日：2001-11-06

    申请号：US09088641

    申请日：1998-06-02

    Applicant: Olga Bandman ,  Phillip R. Hawkins

    Inventor： Olga Bandman ,  Phillip R. Hawkins

    IPC: C12Q168

    CPC classification number: C07K14/47 ,  A61K38/00

    Abstract: The present invention provides a human selenium-binding protein (HSEBP) and polynucleotides which identify and encode HSEBP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEBP and a method for producing HSEBP. The invention also provides for agonists and antibodies specifically binding HSEBP, and their use in the prevention and treatment of diseases associated with expression of HSEBP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEBP for the treatment of diseases associated with the expression of HSEBP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEBP.

    Abstract translation: 本发明提供了人类硒结合蛋白（HSEBP）和识别和编码HSEBP的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSEBP的核酸序列和生产HSEBP的方法。 本发明还提供了特异性结合HSEBP的激动剂和抗体，以及它们在预防和治疗与HSEBP表达相关的疾病中的用途。 另外，本发明提供了将反义分子用于编码HSEBP的多核苷酸用于治疗与HSEBP表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合HSEBP的抗体的诊断测定法。

    Method of detecting human phospholipase inhibitor
    5.
    发明授权
    Method of detecting human phospholipase inhibitor 失效
    检测人磷脂酶抑制剂的方法

    公开(公告)号：US5948626A

    公开(公告)日：1999-09-07

    申请号：US153751

    申请日：1998-09-15

    Applicant: Phillip R. Hawkins ,  Lynn E. Murry

    Inventor： Phillip R. Hawkins ,  Lynn E. Murry

    IPC: G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/68

    CPC classification number: C12Q1/6876 ,  C07K14/4703 ,  A61K38/00 ,  C12Q2600/158

    Abstract: The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.

    Abstract translation: 本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。 本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。 另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。 本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

    Liver expressed chemokine-1
    6.
    发明授权
    Liver expressed chemokine-1 失效
    肝表达趋化因子-1

    公开(公告)号：US5936068A

    公开(公告)日：1999-08-10

    申请号：US798143

    申请日：1997-02-10

    Applicant: Craig G. Wilde ,  Phillip R. Hawkins ,  Olga Bandman ,  Jeffrey J. Seilhamer

    Inventor： Craig G. Wilde ,  Phillip R. Hawkins ,  Olga Bandman ,  Jeffrey J. Seilhamer

    IPC: G01N33/566 ,  C07K14/52 ,  C07K14/715 ,  C07K16/24 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12P21/02 ,  C12Q1/68

    CPC classification number: C07K14/715 ,  C07K14/523 ,  C07K16/24 ,  C12Q1/6876 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S930/14

    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.

    Abstract translation: 本发明提供鉴定和编码来自肝脏和垂体腺组织的新型表达趋化因子（EC）的核苷酸和氨基酸序列。 本发明还提供编码EC的核苷酸序列的反义分子，用于产生纯化的EC的表达载体，能够特异性结合EC的抗体，用于检测编码EC编码的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主 基于编码EC的编码核酸分子或能够特异性结合EC的抗体的ECs表达的细胞，炎症或疾病的诊断性测试，基于编码EC编码的核酸分子的治疗炎症或疾病的药物组合物或能够 特异性地结合EC。

    Human hyaluronidase
    7.
    发明授权
    Human hyaluronidase 失效

    公开(公告)号：US5854046A

    公开(公告)日：1998-12-29

    申请号：US8962

    申请日：1998-01-20

    Applicant: Janice Au-Young ,  Phillip R. Hawkins ,  Jennifer L. Hillman

    Inventor： Janice Au-Young ,  Phillip R. Hawkins ,  Jennifer L. Hillman

    IPC: A61K38/00 ,  C12N1/21 ,  C12N9/26 ,  C12N15/56

    CPC classification number: C12N9/2408 ,  A61K38/00

    Abstract: The present invention provides a polynucleotide (hhp) which identifies and encodes a novel human hyaluronidase (HHP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HHP. The invention also provides for the use of substantially purified HHP and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HHP. Additionally, the invention provides for the use of antisense molecules to hhp in pharmaceutical compositions for treatment of diseases associated with the expression of HHP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of hhp. The present invention also relates to anti-HHP antibodies which specifically bind to HHP.

    Human map kinase homolog
    8.
    发明授权
    Human map kinase homolog 失效
    人地图激酶同源物

    公开(公告)号：US5846778A

    公开(公告)日：1998-12-08

    申请号：US920296

    申请日：1997-08-28

    Applicant: Phillip R. Hawkins ,  Janice Au-Young ,  Karl J. Guegler ,  Craig G. Wilde

    Inventor： Phillip R. Hawkins ,  Janice Au-Young ,  Karl J. Guegler ,  Craig G. Wilde

    IPC: A61K38/00 ,  C12N9/12 ,  C12N15/00 ,  C07H21/04 ,  C07K14/435

    CPC classification number: C12N9/1205 ,  C12N9/12 ,  A61K38/00 ,  Y10S530/827

    Abstract: The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.

    Abstract translation: 本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。 本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和 用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

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