公开(公告)号：US20050247322A1

公开(公告)日：2005-11-10

申请号：US11086620

申请日：2005-03-22

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61F2/02 ,  A61B19/00

CPC classification number: A61F2/02 ,  A61B2017/00827

Abstract: A system includes an implantable polymer for increasing the dimensions of layers of tissue. In one embodiment, the implantable polymer is delivered transorally using an endoscope and an injection needle. The system allows for visualization and injection of polymer into an esophageal sphincter. Methods of treating gastroesophageal reflux disease include insertion of the distal portion of the injection needle into the esophageal tissue and injection of a polymer liquid to enlarge tissue dimensions. The polymer can be injected at several sites to distribute localized pressures and attain better distribution of the tissue bulking effect.

Abstract translation: 系统包括用于增加组织层的尺寸的可植入聚合物。 在一个实施方案中，可植入聚合物通过内窥镜和注射针经过递送。 该系统允许聚合物可视化和注入食管括约肌。 治疗胃食管反流疾病的方法包括将注射针的远端部分插入食管组织并注射聚合物液体以扩大组织尺寸。 聚合物可以在几个部位注射以分配局部压力并获得更好的组织膨胀效应分布。

公开(公告)号：US20050129733A1

公开(公告)日：2005-06-16

申请号：US11010629

申请日：2004-12-09

Applicant: Michael Milbocker ,  Dix Poppas

Inventor： Michael Milbocker ,  Dix Poppas

IPC: A61F2/00 ,  A61L24/04 ,  A61K31/74 ,  A61K31/785

CPC classification number: A61L24/043 ,  A61F2/0063 ,  A61L24/0031 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/046 ,  A61L2400/06 ,  A61L2430/34 ,  C08L71/02

Abstract: The present invention provides a liquid polymer composition which can be implanted into a living mammal and which forms a solid hydrogel by in situ polymerization upon contact with body fluid and tissue. The composition also can be used as a coating on a medical device, or for the formation of a medical device. Formation of a solid implant or coating involves crosslinking of the adhesive with itself and with surrounding tissue. The liquid implant, by itself or in conjunction with various prostheses, can be used for many purposed, including fixation of the urethra for providing treatment for incontinence, and repair of herniations in the abdominal cavity, including rectocele, cystocele, enterocele, and inguinal hernia. The adhesive may be used to establish adhesion prevention during such repairs, in part by coating or being the material of a repair mesh.

Abstract translation: 本发明提供一种液体聚合物组合物，其可以植入活的哺乳动物中，并且通过在与体液和组织接触时通过原位聚合形成固体水凝胶。 该组合物还可以用作医疗装置上的涂层或用于形成医疗装置。 固体植入物或涂层的形成涉及粘合剂与其自身和周围组织的交联。 液体植入物本身或与各种假体结合可以用于许多目的，包括固定尿道以提供尿失禁治疗，以及修复腹腔中的疝气，包括直肠，膀胱，肠套和腹股沟疝 。 粘合剂可以用于在这种修复期间建立粘合防止，部分地通过涂覆或作为修补网的材料。

公开(公告)号：US20060198816A1

公开(公告)日：2006-09-07

申请号：US11411283

申请日：2006-04-26

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61F2/02 ,  A61K31/785

CPC classification number: A61L27/50 ,  A61F2/0036 ,  A61L27/18 ,  C08L75/04

Abstract: The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised of: living tissue, optionally body derived fluids, and at least one NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate, and oxyethylene-containing diols or polyols in which essentially all of hydroxyl groups are capped with polyisocyanate.

公开(公告)号：US20050215748A1

公开(公告)日：2005-09-29

申请号：US11092396

申请日：2005-03-29

Applicant: Michael Milbocker

Inventor： Michael Milbocker

IPC: A61F2/02 ,  A61K31/785 ,  A61L24/04 ,  A61L27/18 ,  C08G18/00 ,  C08G18/12 ,  C08G18/48 ,  C09J175/08

CPC classification number: A61K31/785 ,  A61L24/046 ,  A61L27/18 ,  C08G18/12 ,  C08G18/4812 ,  C09J175/08 ,  C08L75/04 ,  C08G18/302

Abstract: This application describes specific ratios of raw ingredients and methods of combining and reacting those ingredients to obtain polyurethane prepolymers optimized for the special purpose of forming bonds to living tissue, or of bulking or sealing it. Preferred prepolymers are based on polyalkylene oxides, particular copolymers of ethylene oxide and propylene oxide. Important method steps are rigorous drying and deionization, and rigorous control of temperature during synthesis and use.

Abstract translation: 本申请描述了原料成分的特定比例和组合和反应这些成分的方法，以获得为生物组织粘结特殊目的而优化的聚氨酯预聚物，或膨胀或密封。 优选的预聚物是基于聚环氧烷，特别是环氧乙烷和环氧丙烷的共聚物。 重要的方法步骤是严格的干燥和去离子，以及在合成和使用期间严格控制温度。

公开(公告)号：US20050070913A1

公开(公告)日：2005-03-31

申请号：US10873899

申请日：2004-06-22

Applicant: Michael Milbocker ,  Jeffrey Wilson ,  Robert Arcangeli

Inventor： Michael Milbocker ,  Jeffrey Wilson ,  Robert Arcangeli

IPC: A61B17/16 ,  A61B17/58 ,  A61B17/88

CPC classification number: A61B17/1671 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/8897 ,  A61B50/30

Abstract: Surgical methods of repairing defects and deficiencies in the spine are disclosed. The methods involve delivering a single part in-situ polymerizing fluid to (i) close a weakened segment or fissure in the annulus fibrosus, (ii) strengthen the annulus, (iii) replace or augment the disc nucleus, or (iv) localize a disc prosthesis. The methods may include placing a delivery conduit adjacent to the repair site and providing a liquid tissue adhesive to bond to and repair a disc defect or deficiency

Abstract translation: 公开了修复脊柱缺陷和缺陷的手术方法。 该方法包括将单一部分原位聚合的流体递送至（i）闭合纤维环中的弱化部分或裂缝，（ii）加强环，（iii）替换或增加椎间盘细胞核，或（iv） 椎间盘假体 所述方法可以包括将输送导管放置在邻近于修复部位并提供液体组织粘合剂以粘合并修复椎间盘缺损或缺陷