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11.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex 有权与p38多tRNA合成酶复合物的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09062302B2
公开(公告)日：2015-06-23
申请号：US13696049
申请日：2011-05-04
Applicant: Leslie Ann Greene , Kyle P. Chiang , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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12.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases 有权与甲硫氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08981045B2
公开(公告)日：2015-03-17
申请号：US13696044
申请日：2011-05-03
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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13.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases 有权与Lysyl-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08962560B2
公开(公告)日：2015-02-24
申请号：US13700998
申请日：2011-06-01
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/622 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20130224173A1
公开(公告)日：2013-08-29
申请号：US13696048
申请日：2011-05-04
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
IPC: C12N9/00
CPC classification number: C07K16/40 , A61K9/0019 , A61K9/14 , A61K38/53 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/569 , C07K2317/94 , C12N9/93 , C12N9/96
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US20120109097A1
公开(公告)日：2012-05-03
申请号：US13007211
申请日：2011-01-14
Applicant: Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry D. Watkins
Inventor： Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry D. Watkins
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
Abstract: The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.
Abstract translation: 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。
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Patent Agency Ranking
公开(公告)号：US20100303726A1
公开(公告)日：2010-12-02
申请号：US12813352
申请日：2010-06-10
Applicant: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
Inventor： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC: A61K49/00 , C07K16/18 , C07H21/04 , A61K39/395 , A61P35/00
CPC classification number: C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
Abstract translation: 本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性 隐形胶原表位的结合活性。 本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。
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公开(公告)号：US20090047277A1
公开(公告)日：2009-02-19
申请号：US11769326
申请日：2007-06-27
Applicant: Jennifer Lynne REED , Herren Wu , Ying Tang , Julian Davies , Jeffry D. Watkins
Inventor： Jennifer Lynne REED , Herren Wu , Ying Tang , Julian Davies , Jeffry D. Watkins
IPC: A61K39/395 , C07K16/18 , G01N33/53 , A61P43/00
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
Abstract: The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.
Abstract translation: 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。
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公开(公告)号：US07354584B2
公开(公告)日：2008-04-08
申请号：US10823253
申请日：2004-04-12
Applicant: Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry D. Watkins
Inventor： Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry D. Watkins
IPC: A61K39/395 , G01N33/53
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
Abstract: The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.
Abstract translation: 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。
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公开(公告)号：US07175996B1
公开(公告)日：2007-02-13
申请号：US10110141
申请日：2000-10-13
Applicant: Jeffry D. Watkins , William D. Huse , Herren Wu
Inventor： Jeffry D. Watkins , William D. Huse , Herren Wu
IPC: C12P21/06 , C12P21/08 , C07H21/04 , A61K39/395
CPC classification number: C07K16/465 , C07K16/00 , C07K16/2878 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/92
Abstract: The present invention relates to compositions and methods of producing higher affinity molecules, and in particular, higher affinity antibodies. Specifically, the invention contemplates methods of mutagenesis to create a population of oligonucleotides coding for altered polypeptides that are expressed in a host cell and subsequently sequenced to determine the amino acid determinants conferring higher affinity.
Abstract translation: 本发明涉及产生更高亲和力分子的组合物和方法，特别是高亲和力抗体。 具体地，本发明考虑了诱变方法以产生编码在宿主细胞中表达的随后测序的改变的多肽的寡核苷酸群，以确定赋予更高亲和力的氨基酸决定簇。
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公开(公告)号：US07070973B2
公开(公告)日：2006-07-04
申请号：US09748739
申请日：2000-12-26
Applicant: Oksana Lockridge , Jeffry D. Watkins
Inventor： Oksana Lockridge , Jeffry D. Watkins
CPC classification number: C12Y301/01008 , A61K38/00 , C12N9/18 , C12Q1/46
Abstract: The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
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