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26 条记录 (耗时 0.021 秒)

    1,4-dihydropyridine derivatives
    16.
    发明授权
    1,4-dihydropyridine derivatives 失效
    1,4-二氢吡啶衍生物

    公开(公告)号：US5286869A

    公开(公告)日：1994-02-15

    申请号：US492951

    申请日：1990-03-12

    申请人： Hiroshi Ikawa ,  Akiyoshi Kadoiri ,  Yasuo Sekine

    发明人： Hiroshi Ikawa ,  Akiyoshi Kadoiri ,  Yasuo Sekine

    IPC分类号： C07D401/12

    CPC分类号： C07D401/12

    摘要： 1,4-Dihydropyridine derivatives of formula: ##STR1## wherein Ar.sup.1 represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R.sup.1 represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of --R--O--N.dbd.CH--, --R--N.dbd.N--, --R--CH.dbd.N-- and --R--N.dbd.CH--, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar.sup.2 represents an aromatic hydrocarbon group or a heterocyclic group; Ar.sup.3 represents a heterocyclic group which may have one or more substituents; and n is 0 or 1, and the corresponding optical active 1,4-dihydropyridine derivatives, having an optically active cite as indicated by *, have both superior vasodilative and platelet aggregation inhibiting activities.

    摘要翻译： 其中Ar 1表示芳族烃基或含有选自氧，硫和氮的1至3个原子的芳族杂单环或杂双环基; R1表示可具有一个或多个取代基的烃基; A表示（i）直链或支链不饱和烃基，（ii）环状不饱和烃基，或（iii）选自-RON = CH-，-RN = N-，-R -CH = N-和-RN = CH-，其中R是具有1至6个碳原子的亚烷基; B表示可以具有取代基的碳原子数1〜3的亚烷基或亚烯基; Ar 2表示芳香族烃基或杂环基; Ar 3表示可以具有一个以上取代基的杂环基; 并且n为0或1，并且具有如*所示的光学活性引物的相应的光学活性1,4-二氢吡啶衍生物具有优异的血管扩张和血小板聚集抑制活性。

    Method of producing 2-naphthamide derivative, and compounds for producing 2-naphthamide derivative
    17.
    发明授权
    Method of producing 2-naphthamide derivative, and compounds for producing 2-naphthamide derivative 失效
    2-萘甲酰胺衍生物的制造方法以及2-萘甲酰胺衍生物的制造方法

    公开(公告)号：US5714613A

    公开(公告)日：1998-02-03

    申请号：US657545

    申请日：1996-06-04

    申请人： Hiroshi Ikawa ,  Masato Nishimura

    发明人： Hiroshi Ikawa ,  Masato Nishimura

    IPC分类号： C07D213/30 ,  C07D319/08 ,  C07D401/12 ,  C07D405/12 ,  C07D211/06

    CPC分类号： C07D213/30 ,  C07D319/08 ,  C07D401/12 ,  C07D405/12

    摘要： A method of producing a 2-naphthamide derivative of formula (I) that can be employed as an antiallergic agent or an agent for curing allergosis, and compounds for producing the 2-naphthamide derivative are provided: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an unsubstituted or substituted aromatic hydrocarbon group, or an unsubstituted or substituted aromatic heterocyclic group; R.sup.3 is an acyl group, an alkoxylcarbonyl group, a substituted carbamoyl group, or an unsubstituted or substituted alkyl group.

    摘要翻译： 提供了可用作抗过敏剂或用于治疗过敏原的药剂的式（I）的2-萘甲酰胺衍生物的方法和用于制备2-萘甲酰胺衍生物的化合物：其中R1和 R2各自独立地为未取代或取代的芳族烃基，或未取代或取代的芳族杂环基; R3是酰基，烷氧基羰基，取代的氨基甲酰基或未取代或取代的烷基。