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公开(公告)号：US20240055076A1
公开(公告)日：2024-02-15
申请号：US18266387
申请日：2021-12-09
CPC分类号： G16B35/00 , G16B20/20 , C12N15/1089
摘要： The present application features methods of treating a disease associated with a genetic variant. The genetic variant is also present within a novel open reading frame (nORF) associated with the gene in which the variant encodes either the gain or loss of a stop codon.
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公开(公告)号：US20230416938A1
公开(公告)日：2023-12-28
申请号：US18367328
申请日：2023-09-12
摘要： A composite layer of carbon nanotubes and metal such as copper is formed by electrodeposition. The layer has a thickness of at least 10 μm. The carbon nanotubes are distributed through the layer and are present in the layer at a volume fraction of at least 0.001 vol % and at most 65 vol %. The volume fraction is based on the total volume of the metal and carbon nanotubes and not including any pore volume. The carbon nanotubes are substantially uniformly plated with the metal. The composite layer has a density ratio satisfying Player Pmetal ≤0.35 where player is the bulk density of the composite layer of thickness of at least 10 μm, including any voids that are present in the composite layer and pmetal is the volumetric mass density material property of the metal. The composite layer is of use in evaporation-condensation apparatus, as an active material layer in an electrochemical device or in an electroforming process.
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公开(公告)号：US20230416815A1
公开(公告)日：2023-12-28
申请号：US18025664
申请日：2021-09-14
IPC分类号： C12Q1/6874 , C12Q1/6818 , C07D213/61 , C07D213/81 , C07D213/75
CPC分类号： C12Q1/6874 , C12Q1/6818 , C12Q1/6806 , C07D213/81 , C07D213/75 , C07D213/61
摘要： The invention provides a method for labeling a nucleic acid comprising N6-methyl adenine. The method comprises forming an alpha-amino radical on the N6-methyl group of N6mAde, and capturing the alpha-amino radical with a radical acceptor comprising a nitrosopyridyl group. The presence of N6mAde in a nucleic acid may then be established by detection of the labeled nucleic acid, or the labeled nucleic acid may be extracted or further modified using the label. Also provided is a method for mapping the position of N6mAde within a target nucleic acid, and probe molecules and kits for use in the method.
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公开(公告)号：US11752176B2
公开(公告)日：2023-09-12
申请号：US16493888
申请日：2018-03-15
发明人： Charles E. Murry , Sanjay Sinha , Johannes Bargehr
IPC分类号： A61K35/34 , A61K35/545 , A61K31/4409 , A61K38/13 , A61K38/30 , A61P9/10 , A61P9/04 , C12N5/00
CPC分类号： A61K35/34 , A61K31/4409 , A61K35/545 , A61K38/13 , A61K38/30 , A61P9/04 , A61P9/10
摘要： Provided herein are methods and compositions comprising cardiomyocytes and epicardial cells for the treatment of cardiac disease.
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公开(公告)号：US20230204620A1
公开(公告)日：2023-06-29
申请号：US17926794
申请日：2021-05-18
发明人： Ashwin SESHIA , Chun ZHAO
IPC分类号： G01P15/097 , G01P1/00
CPC分类号： G01P15/097 , G01P1/00
摘要： An accelerometer comprising: a frame; one or more proof masses suspended from the frame by one or more flexures and movable relative to the frame along a sensing axis; a first resonant element fixed between an anchor on the frame and the one or more proof masses, and extending from the anchor to the one or more proof masses along the sensing axis; a second resonant element fixed between the anchor and the one or more proof masses and extending from the anchor to the one or more proof masses along the sensing axis in a opposite direction to the first resonant element.
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公开(公告)号：US20230158732A1
公开(公告)日：2023-05-25
申请号：US17917165
申请日：2021-04-06
IPC分类号： B29C64/118 , B29C64/321 , B29C64/40 , B33Y10/00 , B33Y80/00
CPC分类号： B29C64/118 , B29C64/40 , B29C64/321 , B33Y10/00 , B33Y80/00 , B29K2995/0032 , B29K2995/0041 , B29L2031/753
摘要： Various methods of additive layer manufacturing, and objects obtainable by such manufacturing, are disclosed. In particular, there is provided a method of additive layer manufacturing comprising depositing a layer of a material on a surface, and controlling the deposition to vary a material property of the material within the layer. There is also provided a method of additive layer manufacturing comprising depositing at least one layer of material on a sacrificial layer, the layer of material having a thickness of 400 microns or less, wherein the sacrificial layer is located on a base surface.
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公开(公告)号：US11630037B2
公开(公告)日：2023-04-18
申请号：US16644846
申请日：2018-09-18
摘要： A particle sensing device is disclosed for sensing particles entrained in a gas, distribution of particle sizes including a first size range (e.g. PM2.5) and a second size range (e.g. PM10), larger than the first size range. A thermophoretic impulse is applied to the entrained particles. The device has a a first sensor, downstream of the thermophoretic impulse region. The thermophoretic impulse, the flow of gas and gravity combine to cause at least some of the particles to follow respective trajectories within the sampling volume. An interception unit is interposed between the thermophoretic impulse region and the first sensor, to intercept the respective trajectories of particles of the second size range but not respective trajectories of particles of the first size range. The first sensor is located to intercept and detect the respective trajectories of particles of the first size range.
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公开(公告)号：US20230053938A1
公开(公告)日：2023-02-23
申请号：US17792017
申请日：2021-01-13
摘要： The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.
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公开(公告)号：US20230027723A1
公开(公告)日：2023-01-26
申请号：US17859500
申请日：2022-07-07
摘要： Disclosed herein include systems, devices, and methods for detecting embryo polarization from a 2D image generated from a 3D image of an embryo that is not fluorescently labeled using a convolutional neural network (CNN), e.g., deep CNN.
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公开(公告)号：US11525133B2
公开(公告)日：2022-12-13
申请号：US16428451
申请日：2019-05-31
摘要： This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.
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