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公开(公告)号：US11945842B2
公开(公告)日：2024-04-02
申请号：US17077206
申请日：2020-10-22
发明人： Navin Khanna , Viswanathan Ramasamy
IPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/295 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/295 , C12N7/00 , A61K2039/505 , A61K2039/6075 , A61K2039/70 , C12N2730/10122 , C12N2730/10134 , C12N2730/10151 , C12N2770/24122 , C12N2770/24134 , C12N2770/24151 , Y02A50/30
摘要： The invention provides a recombinant polypeptide comprising the EDIII domain of each of Dengue virus serotype DENV-1, DENV-2, DENV-3, and DENV-4 linked to the N-terminal of HBsAg.
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公开(公告)号：US20240055076A1
公开(公告)日：2024-02-15
申请号：US18266387
申请日：2021-12-09
CPC分类号： G16B35/00 , G16B20/20 , C12N15/1089
摘要： The present application features methods of treating a disease associated with a genetic variant. The genetic variant is also present within a novel open reading frame (nORF) associated with the gene in which the variant encodes either the gain or loss of a stop codon.
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公开(公告)号：US20220062281A1
公开(公告)日：2022-03-03
申请号：US17268440
申请日：2019-08-13
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES-TIFR , CENTRE FOR CELLULAR AND MOLECULAR PLATFORMS NCBS-TIFR , INDIAN INSTITUTE OF INTEGRATIVE MEDICINE , INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
发明人： Satyajit MAYOR , Akankshi MUNJAL , Taslimarlf SAIYED , Anandl KARUMBATl , Ram Aysre VISHWAKARMA , Parvinder Pal SINGH , Shweta SHARMA , Gurunadham MUNAGALA , Kushalava Reddy YEMPALLA , Srinivas AMBALA , Shahid JAMEEL , Satyajit RATH
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/167 , A61K31/235 , A61K31/192 , A61K31/4245 , A61K31/421 , A61K31/27 , A61P31/18
摘要： The compounds of Formula I, II, and III along with their stereoisomers, pharmaceutically acceptable salts, polymorphs, solvates and hydrates thereof are described in the present disclosure. The said compounds restore immune activation in case of infections or a disease associated with an HIV infection in a subject in need thereof.
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公开(公告)号：US20210122787A1
公开(公告)日：2021-04-29
申请号：US17077206
申请日：2020-10-22
发明人： Navin KHANNA , Viswanathan RAMASAMY
IPC分类号： C07K14/005 , A61K39/12 , A61K39/295 , C12N7/00
摘要： The invention provides a recombinant polypeptide comprising the EDIII domain of each of Dengue virus serotype DENV-1, DENV-2, DENV-3, and DENV-4 linked to the N-terminal of HBsAg.
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公开(公告)号：US09914943B2
公开(公告)日：2018-03-13
申请号：US15458040
申请日：2017-03-14
申请人： DEPARTMENT OF BIOTECHNOLOGY MINISTRY OF SCIENCE & TECHNOLOGY , INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (ICGEB)
发明人： Syed Shams Yazdani , Neha Munjal , Anu Jose Mattam
摘要： The present invention provides a modified bacterial strain capable of fermenting both hexose and pentose sugars for production of bioalcohol wherein a promoter of pyruvate dehydrogenase operon (PDH) is replaced with a promoter of a gene that is expressed under anaerobic conditions. The present invention further provides a method of obtaining modified bacterial strain capable of fermenting both hexose and pentose sugar for production of bioalcohol. The present invention also provides a method of fermenting lignocellulosic biomass having hexose and pentose sugar using the modified bacteria for production of biomass.
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公开(公告)号：US20220387625A1
公开(公告)日：2022-12-08
申请号：US17820243
申请日：2022-08-16
发明人： MAURO GIACCA , Giulia Ruozi , Francesca Bortolotti
摘要： A protein selected from the group consisting of Chrdl1, Fam3c, Fam3b and a fragment thereof, or a polynucleotide encoding therefor, for use in treating or reducing the risk of heart disease.
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公开(公告)号：US11236332B2
公开(公告)日：2022-02-01
申请号：US16400333
申请日：2019-05-01
IPC分类号： C12N15/11 , C12N15/113 , C12N5/077 , G01N33/50 , A61K48/00
摘要： The present invention discloses a set of human microRNAs, or a primary transcript for such microRNAs, or a precursor of such microRNAs, or a mimic of such microRNAs or a combination thereof, and their use as medicaments for inducing proliferation of cardiomyocytes for the prevention and treatment of heart diseases associated with a loss of cardiomyocytes. The invention also relates to a method for screening microRNAs and biological and therapeutically active compounds for their ability to increase proliferation of cardiomyocytes.
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公开(公告)号：US20170260549A1
公开(公告)日：2017-09-14
申请号：US15458040
申请日：2017-03-14
申请人： DEPARTMENT OF BIOTECHNOLOGY MINISTRY OF SCIENCE & TECHNOLOGY , INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (ICGEB)
发明人： Syed Shams YAZDANI , Neha MUNJAL , Anu Jose MATTAM
摘要： The present invention provides a modified bacterial strain capable of fermenting both hexose and pentose sugars for production of bioalcohol wherein a promoter of pyruvate dehydrogenase operon (PDH) is replaced with a promoter of a gene that is expressed under anaerobic conditions. The present invention further provides a method of obtaining modified bacterial strain capable of fermenting both hexose and pentose sugar for production of bioalcohol. The present invention also provides a method of fermenting lignocellulosic biomass having hexose and pentose sugar using the modified bacteria for production of biomass.
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公开(公告)号：US20230414724A1
公开(公告)日：2023-12-28
申请号：US18339842
申请日：2023-06-22
CPC分类号： A61K38/45 , A61K48/0058 , A61K48/0066 , C12N9/1051 , C12N15/86 , C12N7/00 , C12Y204/01017 , C12N2750/14143 , C12N2830/008 , C12N2830/42
摘要： The invention relates to a nucleic acid sequence useful in the treatment of hyperbilirubinemia, in particular in the treatment of Crigler-Najjar syndrome. More particularly, the nucleic acid sequence of the present invention is a codon-optimized UGT1A1 coding sequence.
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公开(公告)号：US20220193260A1
公开(公告)日：2022-06-23
申请号：US17606080
申请日：2020-04-30
发明人： Mauro Giacca , Giulia Ruozi , Francesca Bortolotti
摘要： A protein selected from the group consisting of Chrdl1, Fam3c, Fam3b and a fragment thereof, or a polynucleotide encoding therefor, for use in treating or reducing the risk of heart disease.
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