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公开(公告)号:US09694021B2
公开(公告)日:2017-07-04
申请号:US14085230
申请日:2013-11-20
申请人: Alcon Research, Ltd.
IPC分类号: A61K31/662 , A61K31/66 , A61K33/42 , A61K9/00
CPC分类号: A61K31/66 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K31/662 , A61K33/42 , A61K2300/00
摘要: The present invention is related to pharmaceutical compositions that include a phosphonium antimicrobial agent. In a preferred embodiment, the present invention relates to an otic, nasal or ophthalmic composition (e.g., an aqueous ophthalmic solution) that includes a phosphonium salt compound as an antimicrobial agent. The compositions typically possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements and/or similar preservative standards (e.g., EP and JP).
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公开(公告)号:US09681983B2
公开(公告)日:2017-06-20
申请号:US14208201
申请日:2014-03-13
申请人: Alcon Research, Ltd.
发明人: Casey Lind
CPC分类号: A61F9/00781
摘要: An IOP control system for treatment of an ocular condition includes a drainage device sized for implantation into the eye of the patient, the drainage device including a fluid flow pathway to allow the flow of fluid from an inlet port to an outlet port. The drainage device also includes a flow system disposed within the drainage device and including a displaceable portion forming a part of the fluid flow pathway, the displaceable portion being displaceable via a magnetic field. An actuation system may be physically separate from the drainage device and may be configured to cooperate with the displaceable portion to displace the displaceable portion via the magnetic field to set free buildup or debris in the flow pathway.
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公开(公告)号:US09622910B2
公开(公告)日:2017-04-18
申请号:US13709638
申请日:2012-12-10
申请人: Alcon Research, Ltd.
IPC分类号: A61M5/00 , A61F9/007 , F16K7/17 , F16K31/126 , F15C3/04
CPC分类号: A61F9/00781 , F15C3/04 , F16K1/307 , F16K7/17 , F16K17/048 , F16K31/1266 , F16K31/1268 , G06F17/30702 , G06Q30/02 , G06Q50/01
摘要: A pressure-driven valve is disclosed. The valve includes a housing, a fluid flow channel, and a deflectable portion. The housing comprises a fluid inlet and a fluid outlet. The fluid flow channel extends between the fluid inlet and the fluid outlet. The deflectable portion is disposed within the housing, and defines a portion of the fluid flow channel. The deflectable portion is configured to deflect to increase and decrease a size of the fluid flow channel to regulate fluid flow from the fluid inlet to the fluid outlet. The deflectable portion is disposed and arranged to deflect as a result of pressure differentials between a reference pressure, a fluid flow channel pressure, and an outlet pressure representative of fluid pressure at the fluid outlet.
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公开(公告)号:US09572479B2
公开(公告)日:2017-02-21
申请号:US14280951
申请日:2014-05-19
申请人: Alcon Research,Ltd.
发明人: Ronald T. Smith
CPC分类号: A61B1/0011 , A61B18/22 , A61B90/30 , A61B2017/00526 , A61B2018/00714 , A61B2018/2261 , A61B2018/2277 , A61B2090/306 , A61F9/008 , A61F9/00821 , A61F9/00823 , A61F2009/00863 , Y10T29/49885
摘要: An optical surgical probe includes a handpiece, a light guide within the handpiece, and a multi-spot generator at a distal end of the handpiece. The handpiece is configured to optically couple to a light source. The light guide is configured to carry a light beam from the light source to a distal end of the handpiece. The multi-spot generator includes a faceted optical element with a faceted end surface spaced from a distal end of the light guide. The faceted end surface includes at least one facet oblique to a path of the light beam.
摘要翻译: 光学手术探针包括手持件,手持件内的光导件和位于手持件末端的多点发生器。 手机被配置为光学耦合到光源。 光导被配置为将来自光源的光束传送到手持件的远端。 多点发生器包括具有与光导的远端间隔开的刻面端面的刻面光学元件。 多面端面包括至少一个倾斜于光束路径的小平面。
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公开(公告)号:US09504691B2
公开(公告)日:2016-11-29
申请号:US14086651
申请日:2013-11-21
申请人: ALCON RESEARCH, LTD.
发明人: Brent G. Boudreaux , Mark J. Bridle , Bryan H. Huynh , Malay Ghosh , Masood A. Chowhan , Laman Alani , Bhagwati P. Kabra
IPC分类号: A61K31/5383 , A61K31/573 , A61K47/02 , A61K47/38 , A61K9/00 , A61K9/10
CPC分类号: A61K31/5383 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/10 , A61K31/573 , A61K47/02 , A61K47/38
摘要: The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a suspension composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin free base or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.
摘要翻译: 本发明涉及用于治疗眼,耳或鼻感染的方法,包括用包含氟尼沙星或氟咪沙星衍生物的悬浮液组合物治疗感染的组织。 本发明还涉及含有氟那沙星游离碱或氟咪沙星衍生物的抗微生物组合物。 该组合物适用于治疗眼,耳或鼻感染。
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公开(公告)号:US09482216B2
公开(公告)日:2016-11-01
申请号:US14302636
申请日:2014-06-12
申请人: Alcon Research, Ltd.
发明人: Gary P. Sorensen
CPC分类号: F04B43/025 , A61M1/0058 , A61M1/0072 , A61M5/14232 , A61M2205/12 , A61M2206/22 , F04B43/1253 , F04B43/1269
摘要: In various embodiments, a surgical cassette, configured to engage peristaltic pump rollers, may include two or more pump segments between a sheet and a substrate coupled to the sheet. The two or more pump segments on the cassette may produce additional flow (e.g., approximately twice the flow for two segments as opposed to one) than if the cassette had only one pump segment engaging the roller. Further, in some embodiments, the two or more pump segments and rollers on the roller head may be configured to provide a flow profile in which a peak of a pulse from a first pump segment is at least partially out of phase with a peak of a pulse from the second pump segment. The combined resultant flow may then have a flow profile with pulsation amplitudes that are smaller than the individual pump segment pulsation amplitudes.
摘要翻译: 在各种实施例中,构造成接合蠕动泵辊的外科手术盒可以包括在片材和连接到片材的衬底之间的两个或更多个泵段。 盒子上的两个或更多个泵段可以产生额外的流量(例如,相对于两个部分,流量大约是两个流量的两倍),而不是如果磁带盒只有一个泵段接合滚筒。 此外,在一些实施例中,辊头上的两个或多个泵段和辊可以被配置成提供流动分布,其中来自第一泵段的脉冲的峰值至少部分地与异相的峰值异相 来自第二泵段的脉冲。 然后,组合的合成流可以具有脉动幅度小于单个泵段脉动幅度的流动分布。
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公开(公告)号:US20160081850A1
公开(公告)日:2016-03-24
申请号:US14955997
申请日:2015-12-01
申请人: Alcon Research, Ltd.
CPC分类号: A61F9/00745 , A61B2217/005 , A61B2217/007 , A61M1/0025 , A61M1/0031 , A61M1/0058 , A61M2205/3331 , A61M2210/0612
摘要: A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; an irrigation pressure sensor located at or along the pressurized irrigation fluid source or irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the irrigation pressure sensor and an estimated flow value modified by a compensation factor.
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18.
公开(公告)号:US09226819B2
公开(公告)日:2016-01-05
申请号:US13961287
申请日:2013-08-07
申请人: Alcon Research, Ltd.
发明人: David A. Downer
IPC分类号: A61F2/16
CPC分类号: A61F2/167 , A61F2/1678
摘要: The present invention is directed to the provision of an intraocular lens delivery device having a plunger with a multi-part plunger tip. The plunger tip includes a first part and a second part wherein the first part releases from the second part during travel of the plunger through the body of a delivery cartridge.
摘要翻译: 本发明涉及提供一种具有多部分柱塞头的柱塞的眼内透镜输送装置。 柱塞尖端包括第一部分和第二部分,其中第一部分在柱塞行进通过输送筒的主体期间从第二部分释放。
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19.
公开(公告)号:US20150359673A1
公开(公告)日:2015-12-17
申请号:US14835090
申请日:2015-08-25
申请人: ALCON RESEARCH, LTD.
发明人: MIKHAIL BOUKHNY , ALEXANDER N. ARTSYUKHOVICH , RAPHAEL GORDON , TIFFANY M. SUTLIFF , CRAIG G. WOOLDRIDGE
CPC分类号: A61F9/00802 , A61B3/13 , A61B34/20 , A61B34/25 , A61B90/20 , A61B90/36 , A61B90/37 , A61B2034/107 , A61B2034/258 , A61B2090/371 , A61F9/007 , A61F9/008
摘要: An ophthalmic surgical system includes a display device and a user interface. The display device generates a display on an image of a patient's eye comprising a plurality of non-overlapping display sectors. Each display sector displays one of a plurality of user-selectable surgical parameters. A user interface receives a user selection of one or more of the user-selectable surgical parameters to be displayed.
摘要翻译: 眼科手术系统包括显示装置和用户界面。 显示装置生成包括多个不重叠的显示扇区的患者眼睛的图像上的显示。 每个显示扇区显示多个用户可选择的手术参数之一。 用户界面接收用户选择要显示的一个或多个用户可选择的手术参数。
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公开(公告)号:US20150272781A1
公开(公告)日:2015-10-01
申请号:US14435541
申请日:2012-11-20
申请人: ALCON RESEARCH, LTD.
发明人: Guido Vezzu
IPC分类号: A61F9/007
CPC分类号: A61F9/00745 , A61B2017/320078 , A61B2090/0817 , A61G12/001
摘要: In certain embodiments, a handpiece system comprises an ultrasonic handpiece and a spatula. The ultrasonic hand-piece comprises a vibration source and a horn. The vibration source is configured to produce ultrasonic vibrations, and a horn is configured to transform the vibrations into ultrasonic motion. The spatula is coupled to the horn and configured to move according to the ultrasonic motion. The spatula may have any suitable shape and size.
摘要翻译: 在某些实施例中,手持系统包括超声波手持件和刮铲。 超声波手柄包括振动源和喇叭。 振动源被配置为产生超声波振动,并且喇叭构造成将振动转换成超声波运动。 刮刀与喇叭连接并配置成根据超声波运动移动。 刮刀可以具有任何合适的形状和尺寸。
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