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    Determination of AM-binding proteins and the association of adrenomedullin (AM) therewith
    12.
    发明授权
    Determination of AM-binding proteins and the association of adrenomedullin (AM) therewith 有权
    AM结合蛋白的测定和肾上腺髓质素（AM）与其结合

    公开(公告)号：US07993857B2

    公开(公告)日：2011-08-09

    申请号：US12638747

    申请日：2009-12-15

    申请人： Frank Cuttitta ,  Ted H. Elsasser ,  Alfredo Martinez ,  Rubén Pío

    发明人： Frank Cuttitta ,  Ted H. Elsasser ,  Alfredo Martinez ,  Rubén Pío

    IPC分类号： G01N1/00 ,  G01N33/53

    CPC分类号： C07K16/18 ,  A61K38/1709 ,  A61K2039/505 ,  G01N33/74 ,  G01N2500/00

    摘要： The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM/AMBP complexes, particularly AM/FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM/fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies. The present invention additionally provides methods for identifying antagonists agents that inhibit the function of AM, factor H, or the AM/factor H complex. The invention also provides methods for treating conditions such as cancer or diabetes using these antagonist agents.

    摘要翻译： 本发明提供了分离，鉴定和纯化肾上腺髓质素（AM）结合蛋白的方法。 此外，提供了利用纯化的AM结合蛋白或其功能部分来诊断，治疗和监测AM相关疾病的方法，例如与异常升高的AM水平相关的疾病或病症。 此外，本发明提供了AM和特异性AM结合蛋白1（AMBP-1）之间新鉴定的复合物; 其在本文中被分离和鉴定为因子H（fH）。 本发明还提供AM / AMBP复合物，特别是AM / FH复合物和与该复合物特异性反应的抗体。 进一步提供了使用抗AM / fH抗体鉴定和纯化AM和AM结合蛋白的复合物的方法，以及使用包含这些抗体的组合物治疗诸如癌症或糖尿病的病症的方法。 本发明另外提供用于鉴定抑制AM，因子H或AM /因子H复合物的功能的拮抗剂的方法。 本发明还提供了使用这些拮抗剂治疗诸如癌症或糖尿病的病症的方法。

    Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit CCR5-tropic HIV-1 infection and replication
    16.
    发明授权
    Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit CCR5-tropic HIV-1 infection and replication 有权
    使用疱疹病毒，疱疹病毒蛋白和编码蛋白质的核酸来抑制CCR5-嗜性HIV-1感染和复制

    公开(公告)号：US07968298B2

    公开(公告)日：2011-06-28

    申请号：US10473560

    申请日：2002-03-28

    申请人： Leonid B. Margolis ,  Jean-Charles Grivel ,  Paolo Lusso

    发明人： Leonid B. Margolis ,  Jean-Charles Grivel ,  Paolo Lusso

    IPC分类号： C12Q1/70 ,  G01N33/53

    CPC分类号： A61K38/162 ,  A61K35/763 ,  A61K48/00 ,  C12N2710/16532

    摘要： It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.

    摘要翻译： 已经发现，疱疹病毒可以引发HIV抑制趋化因子的产生增加，并且这些趋化因子阻断CCR5受体，其被用作HIV-1的CCR5-热带形式的CD4的共受体，其主要是 在早期HIV-1感染。 使用活的，减毒的或杀死的疱疹病毒，或引发HIV抑制趋化因子产生增加的疱疹病毒蛋白质，或编码这些蛋白质的核酸也可用于预防HIV-1感染的建立或抑制HIV- 1复制。 本发明提供了与这些发现相关的用途，方法和组合。

    Multivalent human-bovine rotavirus vaccine
    19.
    发明授权
    Multivalent human-bovine rotavirus vaccine 有权
    多价人 - 牛轮状病毒疫苗

    公开(公告)号：US07932074B1

    公开(公告)日：2011-04-26

    申请号：US09743338

    申请日：1999-07-27

    申请人： Albert Z. Kapikian ,  Robert M. Chanock ,  Yasutaka Hoshino

    发明人： Albert Z. Kapikian ,  Robert M. Chanock ,  Yasutaka Hoshino

    IPC分类号： C12N7/00 ,  A61K39/15

    CPC分类号： A61K39/15 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/70 ,  C12N2720/12334

    摘要： The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.

    摘要翻译： 本发明提供用于保护免受人类轮状病毒病而没有显着的反应原性的疫苗组合物。 将包含人轮状病毒的四种临床上最重要的VP7血清型中的每一种的人×牛重配轮状病毒组合在多价制剂中，其提供高度的感染性和免疫原性，而不产生瞬时发热状况。 还提供了不产生瞬时发热条件产生免疫原性应答的方法。

    Methods and apparatuses for estimating the elliptical cone of uncertainty
    20.
    发明授权
    Methods and apparatuses for estimating the elliptical cone of uncertainty 有权
    用于估计椭圆锥不确定度的方法和装置

    公开(公告)号：US07906965B2

    公开(公告)日：2011-03-15

    申请号：US12263569

    申请日：2008-11-03

    申请人： Cheng Guan Koay

    发明人： Cheng Guan Koay

    IPC分类号： G01V3/00

    CPC分类号： G01R33/56341

    摘要： A magnetic resonance imaging scanner acquires diffusion-weighted imaging data. A reconstruction engine reconstructs the acquired diffusion-weighted imaging data into diffusion-weighted image representations. A diffusion tensor engine constructs a diffusion tensor map of an area of an interest of a subject. An eigenvalue/eigenvector ordering engine obtains and orders eigenvectors and eigenvalues at each voxel. A covariance matrix determining engine constructs a covariance matrix of a major eigenvector of each voxel. A first normalized measure determining engine computes a first normalized measure. A second normalized measure determining engine computes a second normalized measure. A rendering engine generates a human-viewable display of an image representation.

    摘要翻译： 磁共振成像扫描仪获取扩散加权成像数据。 重构引擎将获取的扩散加权成像数据重建为扩散加权图像表示。 扩散张量引擎构建受试者感兴趣区域的扩散张量图。 特征值/特征向量排序引擎在每个体素处获取并排列特征向量和特征值。 协方差矩阵确定引擎构建每个体素的主要特征向量的协方差矩阵。 第一归一化测量确定引擎计算第一归一化测量。 第二归一化测量确定引擎计算第二归一化测量。 渲染引擎生成图像表示的人可见显示。