发明授权
- 专利标题： Multivalent human-bovine rotavirus vaccine
- 专利标题（中）： 多价人 - 牛轮状病毒疫苗
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申请号： US09743338申请日： 1999-07-27
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公开(公告)号： US07932074B1公开(公告)日： 2011-04-26
- 发明人: Albert Z. Kapikian , Robert M. Chanock , Yasutaka Hoshino
- 申请人： Albert Z. Kapikian , Robert M. Chanock , Yasutaka Hoshino
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Kilpatrick, Townsend & Stockton LLP
- 国际申请： PCT/US99/17036 WO 19990727
- 国际公布： WO00/06196 WO 20000210
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; A61K39/15
摘要：
The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.
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