公开(公告)号：US20080294032A1

公开(公告)日：2008-11-27

申请号：US10573242

申请日：2004-09-23

Applicant: Richard Levenson ,  Paul J. Cronin ,  Kirk William Gossage ,  Clifford C. Hoyt

Inventor： Richard Levenson ,  Paul J. Cronin ,  Kirk William Gossage ,  Clifford C. Hoyt

IPC: A61B6/00

CPC classification number: G01N33/5091 ,  A61B5/0059 ,  A61B2562/0242 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/6428 ,  G01N21/6456

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract translation: 本发明的特征在于一种方法，包括：（i）响应于样品的照明，提供关于来自包含深层组织的样品中的不同空间位置的光的光谱解析信息，其中所述光包括来自样品中不同组分的贡献; （ii）将所述不同空间位置中的至少一些中的每一个的所述光谱解析信息分解为与所述样本中的至少一些组件相关联的频谱估计的贡献; 和（iii）基于分解构建样品的深层组织图像，以优先显示所选择的组分之一。

公开(公告)号：US20080225290A1

公开(公告)日：2008-09-18

申请号：US12107718

申请日：2008-04-22

Applicant: Denise M. Wilson ,  Andrew E. Moe

Inventor： Denise M. Wilson ,  Andrew E. Moe

IPC: G01N21/64

CPC classification number: G01J3/4406 ,  G01J3/10 ,  G01N21/645 ,  G01N2201/062 ,  G01N2201/08

Abstract: According to embodiments of the present invention, a fluorescence analysis system includes a light emitting diode to excite a fluorophor sample for analysis. The system includes an LED driver that pulses the LEDs in the array with currents in excess of maximum rated current at low duty cycles. One embodiment receives a first drive current at a light emitting diode (LED), emits excitation light having a first color and/or first wavelength band in response to the first drive current, receives a second drive current at the LED, and emits excitation light having a second color and/or second wavelength band in response to the second drive current, wherein at least one of the drive currents is greater than a nominal drive current for the LED.

Abstract translation: 根据本发明的实施方案，荧光分析系统包括发光二极管以激发用于分析的荧光体样品。 该系统包括一个LED驱动器，可以在低占空比下以超过最大额定电流的电流脉冲阵列中的LED。 一个实施例在发光二极管（LED）处接收第一驱动电流，响应于第一驱动电流发射具有第一颜色和/或第一波长带的激发光，在LED处接收第二驱动电流，并发射激发光 具有响应于所述第二驱动电流的第二颜色和/或第二波长带，其中所述驱动电流中的至少一个大于所述LED的标称驱动电流。

公开(公告)号：US20080225289A1

公开(公告)日：2008-09-18

申请号：US12060170

申请日：2008-03-31

Applicant: Gene Gould ,  Michael J. Conrad

Inventor： Gene Gould ,  Michael J. Conrad

IPC: G01J3/40

CPC classification number: G01N21/6445 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/06 ,  G01J3/12 ,  G01J3/18 ,  G01J3/4406 ,  G01J2003/1217 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2021/6463

Abstract: A fluorescence spectrophotometer system may be implemented in scanning fluorescence polarization detection applications. A wavelength and area scanning fluorescence spectrophotometer system may include a light source, an excitation double monochromator, an excitation/emission light transfer module, an emission double monochromator, a high speed timer-counter circuit board, a precision positioning apparatus for positioning a sample relative to the focal plane of the excitation light, and polarizing filters at the excitation side and the emission side. The system may be operative to analyze more than one fluorescent compound in the sample; additionally or alternatively, the system enables analysis of samples from selected ones of a plurality of samples.

Abstract translation: 荧光分光光度计系统可以在扫描荧光偏振检测应用中实现。 波长和面积扫描荧光分光光度计系统可以包括光源，激发双色单元，激发/发射光传输模块，发射双单色仪，高速定时器 - 计数器电路板，用于定位样品相对的精密定位装置 到激发光的焦平面，以及在激发侧和发射侧的偏振滤光器。 该系统可用于分析样品中多于一种的荧光化合物; 另外或替代地，系统使得能够分析来自多个样本中的选定样本的样本。

公开(公告)号：US07411679B2

公开(公告)日：2008-08-12

申请号：US10953483

申请日：2004-09-29

Applicant: Turan Erdogan ,  Ligang Wang ,  Glenn Clarke

Inventor： Turan Erdogan ,  Ligang Wang ,  Glenn Clarke

IPC: G01N21/25

CPC classification number: G01J3/4406 ,  G02B5/285

Abstract: An optical filter including at least one substrate and first and second thin-film interference filters disposed directly on the substrate. The interference filters include a plurality of hard coating thin film layers of alternating high and low index of refraction. A filter set capable of providing low image shift is also provided.

Abstract translation: 一种滤光器，包括至少一个基板以及直接设置在该基板上的第一和第二薄膜干涉滤光片。 干涉滤光器包括交替的高折射率和低折射率的多个硬涂层薄膜层。 还提供了能够提供低图像偏移的滤光片组。

公开(公告)号：US07400405B2

公开(公告)日：2008-07-15

申请号：US11062048

申请日：2005-02-18

Applicant: Darius Akbar Sadeghi ,  Herbert L. Berman

Inventor： Darius Akbar Sadeghi ,  Herbert L. Berman

IPC: G01N21/25

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/4406 ,  G01J2001/4242 ,  G01J2003/1217 ,  G01N21/645 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221

Abstract: Highly portable, handheld instrument which can be pointed at the produce to be checked. Light from a source within the instrument is directed onto the produce to induce fluorescent emission from the produce, and fluorescent emissions from the produce are monitored with a detector within the instrument to detect the presence of pesticide residue on the produce. The light from the source is filtered to selectively pass light of a wavelength which induces maximum fluorescent emission from the pesticide to be detected, and the emissions from the produce are filtered to selectively pass emissions having a spectral content characteristic of the pesticide to be detected.

Abstract translation: 高度便携的手持式仪器，可以指向要检查的产品。 来自仪器内的源的光被引导到产品上以诱导来自产品的荧光发射，并且用仪器内的检测器监测来自产物的荧光发射以检测产物上农药残留的存在。 来自源的光被过滤以选择性地通过从被检测的农药引起最大荧光发射的波长的光，并且过滤来自产物的排放物以选择性地通过具有要检测的农药的谱含量特征的发射。

公开(公告)号：US20080093539A1

公开(公告)日：2008-04-24

申请号：US11907613

申请日：2007-10-15

Applicant: David Tuschel ,  John Maier

Inventor： David Tuschel ,  John Maier

IPC: G01N21/27 ,  G01N21/31

CPC classification number: G01N21/6428 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6423

Abstract: In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.

Abstract translation: 在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

公开(公告)号：US07352459B2

公开(公告)日：2008-04-01

申请号：US10039769

申请日：2001-12-31

Applicant: Gene Gould ,  Michael J. Conrad

Inventor： Gene Gould ,  Michael J. Conrad

IPC: G01J3/18 ,  G01N21/64

CPC classification number: G01N21/6445 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/06 ,  G01J3/12 ,  G01J3/18 ,  G01J3/4406 ,  G01J2003/1217 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2021/6463

Abstract: A fluorescence spectrophotometer system may be implemented in scanning fluorescence polarization detection applications. A wavelength and area scanning fluorescence spectrophotometer system may include a light source, an excitation double monochromator, an excitation/emission light transfer module, an emission double monochromator, a high speed timer-counter circuit board, a precision positioning apparatus for positioning a sample relative to the focal plane of the excitation light, and polarizing filters at the excitation side and the emission side. The system may be operative to analyze more than one fluorescent compound in the sample; additionally or alternatively, the system enables analysis of samples from selected ones of a plurality of samples.

Abstract translation: 荧光分光光度计系统可以在扫描荧光偏振检测应用中实现。 波长和面积扫描荧光分光光度计系统可以包括光源，激发双色单元，激发/发射光传输模块，发射双单色仪，高速定时器 - 计数器电路板，用于定位样品相对的精密定位装置 到激发光的焦平面，以及在激发侧和发射侧的偏振滤光器。 该系统可用于分析样品中多于一种的荧光化合物; 另外或替代地，系统使得能够分析来自多个样本中的选定样本的样本。

公开(公告)号：US20080063998A1

公开(公告)日：2008-03-13

申请号：US11530987

申请日：2006-09-12

Applicant: Rongguang Liang ,  Victor C. Wong ,  Michael A. Marcus ,  Mark E. Bridges ,  Paul O, McLaughlin ,  Peter D. Burns ,  David L. Patton

Inventor： Rongguang Liang ,  Victor C. Wong ,  Michael A. Marcus ,  Mark E. Bridges ,  Paul O, McLaughlin ,  Peter D. Burns ,  David L. Patton

IPC: A61C3/00 ,  A61C5/00

CPC classification number: A61B5/0088 ,  A61B1/043 ,  A61B1/0607 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/24 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/4547 ,  A61B5/742 ,  A61B5/7425 ,  A61C1/088 ,  G01B9/02091 ,  G01B11/2441 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0224 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/508 ,  G01N21/4795 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/1787

Abstract: An apparatus for obtaining an image of a tooth having at least one light source providing incident light having a first spectral range for obtaining a reflectance image (122) from the tooth and a second spectral range for exciting a fluorescence image (120) from the tooth. A polarizing beamsplitter (18) in the path of the incident light from both sources directs light having a first polarization state toward the tooth and directs light from the tooth having a second polarization state along a return path toward a sensor (68), wherein the second polarization state is orthogonal to the first polarization state. A first lens (22) in the return path directs image-bearing light from the tooth toward the sensor (68), and obtains image data from the portion of the light having the second polarization state. A long-pass filter (15) in the return path attenuates light in the second spectral range.

Abstract translation: 一种用于获得具有至少一个光源的齿的图像的装置，所述至少一个光源提供具有第一光谱范围的入射光，以从所述牙齿获得反射图像（122）和用于从所述牙齿激发荧光图像（120）的第二光谱范围 。 来自两个源的入射光的路径中的偏振分束器（18）将具有第一偏振态的光朝向齿引导，并将来自具有第二偏振态的齿沿着返回路径引导到传感器（68），其中， 第二偏振态与第一偏振态正交。 返回路径中的第一透镜（22）将来自齿的图像承载光朝向传感器（68）引导，并从具有第二偏振状态的光的部分获得图像数据。 返回路径中的长通滤波器（15）衰减第二光谱范围内的光。

公开(公告)号：US20080055584A1

公开(公告)日：2008-03-06

申请号：US11849026

申请日：2007-08-31

Applicant: Atul Pradhan ,  Jay Anzellotti ,  Joseph Foss ,  Ligang Wang ,  Turan Erdogan

Inventor： Atul Pradhan ,  Jay Anzellotti ,  Joseph Foss ,  Ligang Wang ,  Turan Erdogan

IPC: F21V9/04 ,  G01J3/00

CPC classification number: G02B5/283 ,  G01J3/10 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N2021/6471

Abstract: In accordance with the invention, a filter is fabricated by a modified form of the process disclosed in U.S. Pat. No. 7,068,430. In particular, the method is modified to take into account the effect of absorption by filter material. The method is exemplified by the fabricating of an ultraviolet light transmission filter for transmitting a band within the range 230-320 nanometers. The resulting filter comprises plurality of hard-coating, thin-film layers of alternating high and low index of refraction. The improved filter provides high transmission, sharp edge slopes, and deep and extended out-of-band blocking. As compared with currently available filters, the filter provides transmission up to three or more times greater, edge slopes up to four times sharper, and deep extended out-of-band blocking extending further, even through the visible range.

Abstract translation: 根据本发明，通过美国专利公开的方法的改进形式制造过滤器。 No. 7,068,430。 特别地，该方法被修改以考虑由过滤材料吸收的影响。 该方法的例子是制造用于传输在230-320纳米范围内的波段的紫外光透射滤波器。 所得到的过滤器包括交替的高折射率和低折射率的多个硬涂层薄膜层。 改进的滤波器提供高传输，尖锐的边缘斜率，以及深度和扩展的带外阻塞。 与目前可用的滤波器相比，滤波器提供的传输最多三倍或更多倍，边缘斜率高达四倍，并且深度延伸的带外阻挡进一步延伸，甚至在可见光范围内。

公开(公告)号：US07336988B2

公开(公告)日：2008-02-26

申请号：US10082870

申请日：2002-02-25

Applicant: Mark J Schnitzer

Inventor： Mark J Schnitzer

IPC: A61B6/00 ,  G02B6/04 ,  G02B6/06

CPC classification number: G02B23/2446 ,  A61B5/0084 ,  G01J3/4406

Abstract: An apparatus includes an optical element, a GRIN lens, and a detector. The optical element has a first optical aperture. The GRIN lens has first and second ends. The first end of the GRIN lens is positioned to receive light from the first optical aperture. The detector is configured to measure values of a characteristic of light emitted from the first end in response to multi-photon absorption events in a sample illuminated by light from the second end of the endoscopic probe.

Abstract translation: 一种装置包括光学元件，GRIN透镜和检测器。 光学元件具有第一光学孔。 GRIN镜头具有第一和第二端。 GRIN透镜的第一端被定位成接收来自第一光学孔的光。 检测器被配置为响应于来自内窥镜探针的第二端的光照射的样品中的多光子吸收事件，测量从第一端发射的光的特性的值。