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    In situ tissue engineering using magnetically guided three dimensional cell patterning
    133.
    发明授权
    In situ tissue engineering using magnetically guided three dimensional cell patterning 有权
    使用磁导三维细胞图案的原位组织工程

    公开(公告)号：US09051549B2

    公开(公告)日：2015-06-09

    申请号：US13402627

    申请日：2012-02-22

    Applicant: Shawn Patrick Grogan ,  Darryl David D'Lima ,  Clifford W. Colwell, Jr. ,  Sungho Jin

    Inventor： Shawn Patrick Grogan ,  Darryl David D'Lima ,  Clifford W. Colwell, Jr. ,  Sungho Jin

    IPC: C12N5/077 ,  A61K35/00 ,  A61K35/12

    CPC classification number: C12N5/0655 ,  A61K35/12 ,  C12N2529/00 ,  C12N2533/10 ,  C12N2533/74

    Abstract: Methods are provided for the three dimensional manipulation of cells, and for the formation of an organized engineered cell tissue. Also provided are the organized engineered cell tissues produced by the methods. In one method, a plurality of magnetically labeled cells are mixed with a cross-linkable hydrogel to form a cell-hydrogel mixture, the at least a portion of the plurality of magnetically labeled cells are manipulated with a magnetic field to arrange the magnetically labeled cells into a specific cellular arrangement, and the hydrogel is crosslinked to form the organized engineered cell tissue. The approach presented herein offers a means to circumvent the deficiencies in the field of regenerative medicine, and allows for the production of organized tissues in situ with specific cellular organizations that mimic the native tissue.

    Abstract translation: 提供了用于细胞的三维操作以及形成有组织的工程细胞组织的方法。 还提供了通过该方法生产的有组织的工程细胞组织。 在一种方法中，将多个磁性标记的细胞与可交联水凝胶混合以形成细胞 - 水凝胶混合物，用磁场操纵多个磁性标记的细胞的至少一部分，以将磁性标记细胞 进入特定的细胞布置，并且水凝胶被交联以形成有组织的工程细胞组织。 本文提出的方法提供了一种方法来规避再生医学领域的缺陷，并且允许用模拟天然组织的特定细胞组织原位生产有组织的组织。

    Sidewall tracing nanoprobes, method for making the same, and method for use
    135.
    发明授权
    Sidewall tracing nanoprobes, method for making the same, and method for use 有权
    侧壁跟踪纳米探针，制作方法和使用方法

    公开(公告)号：US08245318B2

    公开(公告)日：2012-08-14

    申请号：US12375161

    申请日：2007-07-27

    Applicant: Sungho Jin ,  Li-Han Chen ,  Gregory Dahlen ,  Hao-Chih Liu

    Inventor： Sungho Jin ,  Li-Han Chen ,  Gregory Dahlen ,  Hao-Chih Liu

    IPC: G01Q70/12

    CPC classification number: G01Q60/38 ,  G01Q70/12

    Abstract: Sidewall tracing nanoprobes, in which the tip shape of the nanoprobe Is altered so that the diameter or width of the very tip of the probe is wider than the diameter of the supporting stem. Such side protruding probe tips are fabricated by a subtractive method of reducing the stem diameter, an additive method of increasing the tip diameter, or sideway bending of the probe tip. These sidewall tracing nanoprobes are useful for inspection of semiconductor devices, especially to quantitatively evaluate the defects on the side wall of trenches or via holes.

    Abstract translation: 侧壁跟踪纳米探针，其中纳米探针的尖端形状被改变，使得探针的尖端的直径或宽度比支撑杆的直径宽。 这种侧突出的探针尖端通过减小茎直径的减法方法，增加尖端直径的添加方法或探针尖端的侧向弯曲来制造。 这些侧壁跟踪纳米探针可用于检查半导体器件，特别是定量评估沟槽或通孔侧壁上的缺陷。

    Method for fabricating a long-range ordered periodic array of nano-features, and articles comprising same
    136.
    发明授权
    Method for fabricating a long-range ordered periodic array of nano-features, and articles comprising same 有权
    用于制造纳米特征的长程有序周期性阵列的方法，以及包含其的制品

    公开(公告)号：US08178165B2

    公开(公告)日：2012-05-15

    申请号：US11814338

    申请日：2006-01-23

    Applicant: Sungho Jin

    Inventor： Sungho Jin

    IPC: B05D5/00 ,  B05D3/00

    CPC classification number: B82Y25/00 ,  B01J23/40 ,  B01J35/0013 ,  B01J37/0009 ,  B82Y10/00 ,  B82Y30/00 ,  G06N99/002 ,  G11B5/855 ,  H01F1/009 ,  H01F1/405 ,  Y10S977/849 ,  Y10S977/855 ,  Y10S977/858

    Abstract: A long range, periodically ordered array of discrete nano-features (10), such as nano-islands, nano-particles, nano-wires, non-tubes, nano-pores, nano-composition-variations, and nano-device-components, are fabricated by propagation of a self-assembling array or nucleation and growth of periodically aligned nano-features. The propagation may be induced by a laterally or circularly moving heat source, a stationary heat source arranged at an edge of the material to be patterned (12), or a series of sequentially activated heaters or electrodes. Advantageously, the long-range periodic array of nano-features (10) may be utilized as a nano-mask or nano-implant master pattern for nano-fabrication of other nano-structures. In addition, the inventive long-range, periodically ordered arrays of nano-features are useful in a variety of nanoscale applications such as addressable memories or logic devices, ultra-high-density magnetic recording media, magnetic sensors, photonic devices, quantum computing devices, quantum luminescent devices, and efficient catalytic devices.

    Abstract translation: 长距离定期排列的离散纳米特征（10）阵列，如纳米岛，纳米粒子，纳米线，非管，纳米孔，纳米组成变化和纳米器件组件 ，通过自组装阵列的传播或周期性排列的纳米特征的成核和生长来制造。 传播可以由横向或循环移动的热源，布置在待图案化材料（12）的边缘处的固定热源或一系列顺序活化的加热器或电极引起。 有利地，纳米特征（10）的远距离周期性阵列可以用作纳米掩模或纳米植入物主模式，用于纳米制造其他纳米结构。 此外，本发明的长距离定期排列的纳米特征阵列可用于各种纳米级应用，例如可寻址存储器或逻辑器件，超高密度磁记录介质，磁传感器，光子器件，量子计算设备 ，量子发光装置和有效的催化装置。

    Method for Fabricating a Long-Range Ordered Periodic Array of Nano-Features, and Articles Comprising Same
    139.
    发明申请
    Method for Fabricating a Long-Range Ordered Periodic Array of Nano-Features, and Articles Comprising Same 有权
    制造长距离有序的纳米特征周期阵列的方法，以及包含其的文章

    公开(公告)号：US20080260941A1

    公开(公告)日：2008-10-23

    申请号：US11814338

    申请日：2006-01-23

    Applicant: Sungho Jin

    Inventor： Sungho Jin

    IPC: B05D5/12 ,  B05D3/02

    CPC classification number: B82Y25/00 ,  B01J23/40 ,  B01J35/0013 ,  B01J37/0009 ,  B82Y10/00 ,  B82Y30/00 ,  G06N99/002 ,  G11B5/855 ,  H01F1/009 ,  H01F1/405 ,  Y10S977/849 ,  Y10S977/855 ,  Y10S977/858

    Abstract: A long range, periodically ordered array of discrete nano-features (10), such as nano-islands, nano-particles, nano-wires, non-tubes, nano-pores, nano-composition-variations, and nano-device-components, are fabricated by propagation of a self-assembling array or nucleation and growth of periodically aligned nano-features. The propagation may be induced by a laterally or circularly moving heat source, a stationary heat source arranged at an edge of the material to be patterned (12), or a series of sequentially activated heaters or electrodes. Advantageously, the long-range periodic array of nano-features (10) may be utilized as a nano-mask or nano-implant master pattern for nano-fabrication of other nano-structures. In addition, the inventive long-range, periodically ordered arrays of nano-features are useful in a variety of nanoscale applications such as addressable memories or logic devices, ultra-high-density magnetic recording media, magnetic sensors, photonic devices, quantum computing devices, quantum luminescent devices, and efficient catalytic devices.

    Abstract translation: 长距离定期排列的离散纳米特征（10）阵列，如纳米岛，纳米粒子，纳米线，非管，纳米孔，纳米组成变化和纳米器件组件 ，通过自组装阵列的传播或周期性排列的纳米特征的成核和生长来制造。 传播可以由横向或循环移动的热源，布置在待图案化材料（12）的边缘处的固定热源或一系列顺序活化的加热器或电极引起。 有利地，纳米特征（10）的远距离周期性阵列可以用作纳米掩模或纳米植入物主模式，用于纳米制造其他纳米结构。 此外，本发明的长距离定期排列的纳米特征阵列可用于各种纳米级应用，例如可寻址存储器或逻辑器件，超高密度磁记录介质，磁传感器，光子器件，量子计算设备 ，量子发光装置和有效的催化装置。

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