公开(公告)号：US20220259599A1

公开(公告)日：2022-08-18

申请号：US17611062

申请日：2020-05-14

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan ,  Jessica Chiang ,  George M. Church

IPC: C12N15/117 ,  C12N15/86

Abstract: Provided herein, in some embodiments, are nucleic acid vectors, such as recombinant viral genomes, comprising an inhibitory oligonucleotide that reduces inflammation for use, for example, in gene therapy.

公开(公告)号：US11364259B2

公开(公告)日：2022-06-21

申请号：US16473535

申请日：2017-12-27

Applicant: THE UNIVERSITY OF TOKYO ,  KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

Inventor： Satoshi Uchida ,  Keiji Itaka ,  Kazunori Kataoka ,  Naoto Yoshinaga

IPC: A61K31/711 ,  A61K31/7115 ,  A61K47/69 ,  A61K39/00 ,  C12N15/117

Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.

公开(公告)号：US11345919B2

公开(公告)日：2022-05-31

申请号：US16805544

申请日：2020-02-28

Applicant: Fondazione Edmund Mach

Inventor： Azeddine Si Ammour ,  Roberto Viola ,  Duccio Cavalieri ,  Lisa Rizzetto

IPC: A61K48/00 ,  C07H21/04 ,  C12N15/117 ,  C12N15/113 ,  A61K31/7105 ,  A23L33/105 ,  A23L33/115 ,  A61K9/00 ,  A61K45/06 ,  A61K31/713

Abstract: The present invention relates to a plant sRNA extract for use as an immunosuppressive agent and to plant miRNA for use as an immunosuppressive agent.

公开(公告)号：US20220056069A1

公开(公告)日：2022-02-24

申请号：US17461797

申请日：2021-08-30

Applicant: TOLLNINE, INC.

Inventor： Sukumar Sakamuri ,  Curt W. Bradshaw ,  Son Lam ,  Joseph Stock ,  Edward Hyungsuk Ha ,  Laxman Eltepu ,  Dingguo Liu ,  Bin Liu ,  Giuseppe Dello Iacono ,  Bryan R. Meade ,  Ayman Kabakibi

IPC: C07H21/04 ,  C07K16/28 ,  C12N15/117 ,  C07K16/30 ,  A61K47/68 ,  A61K47/60 ,  A61P35/00 ,  A61K31/7125 ,  A61K39/00 ,  A61K39/39 ,  C07K7/06

Abstract: Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use.

公开(公告)号：US11214805B2

公开(公告)日：2022-01-04

申请号：US16548945

申请日：2019-08-23

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC: A61K39/395 ,  C12N15/117 ,  A61K47/62 ,  A61K47/69 ,  A61K31/395 ,  A61K38/20 ,  C12N15/11 ,  A61K31/365 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/17 ,  A61K35/12

Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

公开(公告)号：US20210348166A1

公开(公告)日：2021-11-11

申请号：US17150668

申请日：2021-01-15

Applicant: Phio Pharmaceuticals Corp.

Inventor： Alexey Wolfson ,  Alexey Eliseev ,  Taisia Shmushkovich

IPC: C12N15/117 ,  A61K39/00 ,  C12N15/113

Abstract: Immunogenic modulators and compositions comprising oligonucleotide agents capable of inhibiting suppression of immune response by reducing expression of one or more gene involved with an immune response suppression mechanism.

公开(公告)号：US11060096B2

公开(公告)日：2021-07-13

申请号：US16265154

申请日：2019-02-01

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： Peixuan Guo ,  Hui Li ,  Emil Khisamutdinov ,  Daniel Jasinski

IPC: C07H21/04 ,  C12N15/117 ,  A61K39/39 ,  A61K39/00

Abstract: The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.

公开(公告)号：US20210128727A1

公开(公告)日：2021-05-06

申请号：US17052835

申请日：2019-05-07

Applicant: Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Inventor： Sebastian Rosigkeit ,  Ernst-Otto Bockamp ,  Detlev Schuppan

IPC: A61K39/395 ,  A61P35/00 ,  A61K45/06 ,  A61K39/39 ,  A61K9/00 ,  C12N15/117

Abstract: The present invention relates to a pharmaceutical combination, comprising the components: a) at least one regulatory T cell (Treg)-depleting agent, b) at least one Toll-like receptor 9 (TLR9) agonist, c) one or more immune checkpoint inhibitors, for use in the treatment of cancer in humans or non-human mammals.

公开(公告)号：US20210123057A1

公开(公告)日：2021-04-29

申请号：US17084460

申请日：2020-10-29

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Ziyin Huang

IPC: C12N15/117 ,  A61K31/7125 ,  A61K47/69

Abstract: The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide shell attached to the external surface of the nanoparticle core, wherein the oligonucleotide shell comprises a mixture of class A CpG oligonucleotides and class B CpG oligonucleotides. The disclosure also provides methods of using the SNAs for, e.g., regulation of an immune response and gene regulation.

公开(公告)号：US10947545B2

公开(公告)日：2021-03-16

申请号：US16349396

申请日：2017-10-27

Applicant: Berlin Cures GmbH

Inventor： Annekathrin Haberland ,  Katrin Wenzel

IPC: C12N15/115 ,  A61K31/713 ,  C12N15/117

Abstract: The present invention relates to new aptamer molecules for use in therapy of a subject by inhibiting or suppressing the activation of TLR9 in a cell, a method of inhibiting or suppressing the activation of TLR9 in a cell using such aptamer molecules, a pharmaceutical composition and a kit comprising such aptamer molecules and the use of aptamer molecules for inhibiting or suppressing TLR9 activation.