Patent search ap:("President AND Fellows of Harvard College") AND inv:"Ying Kai Chan" Page 1

1.

发明公开
ENGINEERED VIRAL VECTOR REDUCES INDUCTION OF INFLAMMATORY AND IMMUNE RESPONSES 审中-公开

公开(公告)号：US20240043849A1

公开(公告)日：2024-02-08

申请号：US18332109

申请日：2023-06-09

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , George M. Church

IPC: C12N15/117 , A61K45/06 , A61K31/7088 , A61K35/76 , C12N15/86 , A61P29/00 , C12N7/00

CPC classification number: C12N15/117 , A61K45/06 , A61K31/7088 , A61K35/76 , C12N15/86 , A61P29/00 , C12N7/00 , C12N2310/17 , C12N2330/51 , C12N2750/00032 , C12N2750/00041 , Y02A50/30 , A61K48/00

Abstract: Modified viral genomes are able to reduce induction of inflammatory and immune antiviral responses. This manifests itself in reduced NF-kB activity, increased viral transduction rates, and increased expression of transgenes. Viral genomes are modified by incorporating one or more oligonucleotide sequences which are able to bind to TLR9 but not induce activation of it. The oligonucleotide sequences may be synthetic, bacterial, human, or from any other source.

2.

发明申请
COMPOSITIONS AND METHODS FOR INHIBITING VIRAL VECTOR-INDUCED INFLAMMATORY RESPONSES 有权

公开(公告)号：US20240384295A1

公开(公告)日：2024-11-21

申请号：US18629140

申请日：2024-04-08

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , George M. Church

IPC: C12N15/86 , C12N15/117

Abstract: Provided herein, in some embodiments, are recombinant viral genomes comprising an inhibitory oligonucleotide that reduces inflammation for use, for example, in gene therapy.

3.

发明授权
Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences 有权

公开(公告)号：US10736957B2

公开(公告)日：2020-08-11

申请号：US16152096

申请日：2018-10-04

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Ying Kai Chan , Jessica Jing-Shiuan Chiang

IPC: A61K39/12 , A61K39/145 , C12N15/117 , A61K39/39 , A61P31/16 , A61K39/00

Abstract: Described herein are in vitro-transcribed (IVT) RNA molecules comprising, a 5′ cap structure, a coding region encoding an antigen polypeptide, an immunostimulatory RNA sequence, and a poly(A) tail.

4.

发明授权
Compositions and methods for inhibiting viral vector-induced inflammatory responses 有权

公开(公告)号：US11981911B2

公开(公告)日：2024-05-14

申请号：US16762356

申请日：2018-11-08

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , George M. Church

IPC: C12N15/86 , C12N15/117

CPC classification number: C12N15/86 , C12N15/117 , C12N2710/10343

Abstract: Provided herein, in some embodiments, are recombinant viral genomes comprising an inhibitory oligonucleotide that reduces inflammation for use, for example, in gene therapy.

5.

发明申请
COMPOSITIONS AND METHODS FOR INHIBITING VIRAL VECTOR-INDUCED INFLAMMATORY RESPONSES 审中-公开

公开(公告)号：US20200270637A1

公开(公告)日：2020-08-27

申请号：US16762356

申请日：2018-11-08

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , George M. Church

IPC: C12N15/86 , C12N15/117

Abstract: Provided herein, in some embodiments, are recombinant viral genomes comprising an inhibitory oligonucleotide that reduces inflammation for use, for example, in gene therapy.

6.

发明申请
COMPOSITIONS AND METHODS FOR INHIBITING NUCLEIC ACID VECTOR-INDUCED INFLAMMATORY RESPONSES 有权

公开(公告)号：US20220259599A1

公开(公告)日：2022-08-18

申请号：US17611062

申请日：2020-05-14

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , Jessica Chiang , George M. Church

IPC: C12N15/117 , C12N15/86

Abstract: Provided herein, in some embodiments, are nucleic acid vectors, such as recombinant viral genomes, comprising an inhibitory oligonucleotide that reduces inflammation for use, for example, in gene therapy.

7.

发明申请
ENHANCED IMMUNOGENICITY OF mRNA WITH CO-ENCODED ADJUVANT SEQUENCES 审中-公开

公开(公告)号：US20190184006A1

公开(公告)日：2019-06-20

申请号：US16152096

申请日：2018-10-04

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Ying Kai Chan , Jessica Jing-Shiuan Chiang , George M. Church

IPC: A61K39/145 , C12N15/117 , A61P31/16 , A61K39/39

Abstract: Described herein are in vitro-transcribed (IVT) RNA molecules comprising, a 5′ cap structure, a coding region encoding an antigen polypeptide, an immunostimulatory RNA sequence, and a poly(A) tail.

8.

发明授权
Engineered viral vector reduces induction of inflammatory and immune responses 有权

公开(公告)号：US11339396B2

公开(公告)日：2022-05-24

申请号：US16308420

申请日：2017-06-08

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , George M. Church

IPC: C12N15/117 , A61K45/06 , A61K31/7088 , A61K35/76 , C12N15/86 , A61P29/00 , C12N7/00 , A61K48/00

Abstract: Modified viral genomes are able to reduce induction of inflammatory and immune anti-viral responses. This manifests itself in reduced NF-kB activity, increased viral transduction rates, and increased expression of transgenes. Viral genomes are modified by incorporating one or more oligonucleotide sequences which are able to bind to TLR9 but not induce activation of it. The oligonucleotide sequences may be synthetic, bacterial, human, or from any other source.

9.

发明申请
ENGINEERED VIRAL VECTOR REDUCES INDUCTION OF INFLAMMATORY AND IMMUNE RESPONSES 审中-公开

公开(公告)号：US20190316151A1

公开(公告)日：2019-10-17

申请号：US16167764

申请日：2018-10-23

Applicant: President and Fellows of Harvard College

Inventor： Ying Kai Chan , George Church

IPC: C12N15/86 , A61K35/76

Abstract: Modified viral genomes are able to reduce induction of inflammatory and immune anti-viral responses. This manifests itself in reduced NF-kB activity, increased viral transduction rates, and increased expression of transgenes. Viral genomes are modified by incorporating one or more oligonucleotide sequences which are able to bind to TLR9 but not induce activation of it. The oligonucleotide sequences may be synthetic, bacterial, human, or from any other source.

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