公开(公告)号：US10428331B2

公开(公告)日：2019-10-01

申请号：US15107536

申请日：2015-01-14

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC: A61K39/395 ,  C12N15/117 ,  A61K31/365 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/17 ,  A61K38/20 ,  C12N15/11 ,  A61K31/395 ,  A61K47/62 ,  A61K47/69 ,  A61K35/12

Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

公开(公告)号：US10458988B2

公开(公告)日：2019-10-29

申请号：US15909020

申请日：2018-03-01

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Yu-Lin Jiang

IPC: G01N33/574 ,  C07D495/04

Abstract: Provided herein are luminescent probes of formula I: and complexes thereof for the detection of cancer cells.

公开(公告)号：US11260027B2

公开(公告)日：2022-03-01

申请号：US15745913

申请日：2016-06-24

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Satish Nadig ,  Carl Atkinson ,  Ann-Marie Broome ,  Suraj K. Dixit

IPC: A61K9/107 ,  A61K9/127 ,  A61K38/13 ,  A61K9/51 ,  A01N1/02 ,  A61K31/436 ,  A61K31/365 ,  A61K38/20 ,  A61K31/713 ,  A61P37/06 ,  A61K31/343 ,  A61K47/10 ,  A61K31/453 ,  B82Y5/00

Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.

公开(公告)号：US20160317670A1

公开(公告)日：2016-11-03

申请号：US15107536

申请日：2015-01-14

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC: A61K47/48 ,  A61K38/13 ,  A61K31/713 ,  A61K31/365 ,  A61K35/17 ,  C12N15/117 ,  A61K31/436 ,  A61K38/17

CPC classification number: C12N15/117 ,  A61K31/365 ,  A61K31/395 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/1793 ,  A61K38/2013 ,  A61K47/62 ,  A61K47/6909 ,  A61K2035/124 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/32

Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

Abstract translation: 公开了一种靶向C3分解产物，整联蛋白或其组合的纳米载体免疫抑制剂，以减少免疫抑制剂的有害全身效应。 还公开了抑制受试者中同种异体免疫应答的方法，例如可以在同种异体移植后发生的同种异体免疫应答。

公开(公告)号：US11214805B2

公开(公告)日：2022-01-04

申请号：US16548945

申请日：2019-08-23

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC: A61K39/395 ,  C12N15/117 ,  A61K47/62 ,  A61K47/69 ,  A61K31/395 ,  A61K38/20 ,  C12N15/11 ,  A61K31/365 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/17 ,  A61K35/12

Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

公开(公告)号：US20200056183A1

公开(公告)日：2020-02-20

申请号：US16548945

申请日：2019-08-23

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC: C12N15/117 ,  A61K38/17 ,  A61K38/13 ,  A61K35/17 ,  A61K31/713 ,  A61K31/436 ,  A61K31/365 ,  C12N15/11 ,  A61K38/20 ,  A61K31/395 ,  A61K47/69 ,  A61K47/62

Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

公开(公告)号：US20180252718A1

公开(公告)日：2018-09-06

申请号：US15909020

申请日：2018-03-01

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Ann-Marie Broome ,  Yu-Lin Jiang

IPC: G01N33/574 ,  C07D495/04

CPC classification number: G01N33/574 ,  C07D495/04 ,  G01N33/57407 ,  G01N33/57492

Abstract: Provided herein are luminescent probes of formula I: and complexes thereof for the detection of cancer cells.