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公开(公告)号：US20100241038A1
公开(公告)日：2010-09-23
申请号：US12727279
申请日：2010-03-19
Applicant: Ryan Edward Sullivan , Brian Pryor , Sean X. Wang
Inventor： Ryan Edward Sullivan , Brian Pryor , Sean X. Wang
CPC classification number: A61N5/0613 , A61N2005/0602
Abstract: A phototherapy method for assisting the transvenous lead placement for cardiac resynchronization therapy (CRT) and dilation of occluded veins for any implantable lead placement. The phototherapy treatment helps increase blood flow, reduce inflammation, and enhance angiogenesis to facilitate optimal positioning of the leads.
Abstract translation: 一种光疗法，用于协助静脉导管放置用于心脏再同步治疗（CRT）和扩张闭塞静脉用于任何可植入引线放置。 光疗治疗有助于增加血流量，减少炎症，并增强血管生成，以促进引线的最佳定位。
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122.发明申请公开(公告)号：US20090181927A1
公开(公告)日：2009-07-16
申请号：US12407481
申请日：2009-03-19
Applicant: Ronald E. Utech , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
Inventor： Ronald E. Utech , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC: A61K31/435 , A61K31/727 , A61K31/337 , A61K31/4355
CPC classification number: C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
Abstract: Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
Abstract translation: 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。
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公开(公告)号：US07511031B2
公开(公告)日：2009-03-31
申请号：US10899834
申请日：2004-07-26
Applicant: James Chen
Inventor： James Chen
CPC classification number: A61N5/062 , A61B18/1815 , A61B2090/378 , A61K41/0057 , A61K41/0071 , A61N5/0601 , A61N2005/0602 , A61N2005/0604 , A61N2005/0609 , A61N2005/0651 , A61N2005/0659
Abstract: The present invention is drawn to apparatus for transcutaneous photodynamic therapy (“PDT”) of a target tissue or compositions in a mammalian subject, which includes a light source that is external to the subject and is selected from among one or a plurality of laser diodes; light emitting diodes; electroluminescent light source; incandescent light sources; cold cathode fluorescent light sources; organic polymer light sources; or inorganic light sources, where the light source is adapted to direct the light in a direction lengthwise and parallel to a vessel wall comprising the lesion.
Abstract translation: 本发明涉及用于哺乳动物受试者的靶组织或组合物的经皮光动力治疗（“PDT”）的装置，其包括在受试者外部并选自一个或多个激光二极管中的光源 ; 发光二极管; 电致发光光源; 白炽光源; 冷阴极荧光灯; 有机聚合物光源; 或无机光源，其中光源适于在长度方向和平行于包括病变的血管壁的方向上引导光。
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124.发明申请Systems and methods for treating superficial venous malformations like spider veins 有权用于治疗浅静脉畸形的系统和方法，如蜘蛛静脉公开(公告)号：US20090082714A1
公开(公告)日：2009-03-26
申请号：US12313749
申请日：2008-11-24
Applicant: Killian O'Dowd , Anthony Jakubowski , Edward George Mackay, II , Aidan Mulloy , Alan A. Creamer , Sherif Sultan
Inventor： Killian O'Dowd , Anthony Jakubowski , Edward George Mackay, II , Aidan Mulloy , Alan A. Creamer , Sherif Sultan
CPC classification number: A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0644 , A61N2005/0652
Abstract: Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.
Abstract translation: 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布光反应剂例如维替泊芬。 系统和方法通过在激活光反应剂的波长处施加非热光能来激活光反应剂，引起对静脉内壁的局部损伤。
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公开(公告)号：US20080281305A1
公开(公告)日：2008-11-13
申请号：US11746829
申请日：2007-05-10
Applicant: Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
Inventor： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
CPC classification number: A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
Abstract: An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
Abstract translation: 可植入医疗装置包括并入血管内支架中的发光电路。 发光电路将光发射到缺血区域。 该光具有适合于重现与缺血相关的心绞痛症状的特征。
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Patent Agency Ranking
公开(公告)号：US20080269846A1
公开(公告)日：2008-10-30
申请号：US12101069
申请日：2008-04-10
Applicant: Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
Inventor： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
CPC classification number: A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
Abstract: Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
Abstract translation: 用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。 第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。 如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。 第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。 另一种装置是具有两个气囊的导管和在其间延伸的套管。 在套管内，导管包括光源和扩张构件。
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公开(公告)号：US20080058786A1
公开(公告)日：2008-03-06
申请号：US11895563
申请日：2007-08-24
Applicant: Edward Boyden , Roderick Hyde , Muriel Ishikawa , Eric Leuthardt , Nathan Myhrvold , Dennis Rivet , Thomas Weaver , Lowell Wood
Inventor： Edward Boyden , Roderick Hyde , Muriel Ishikawa , Eric Leuthardt , Nathan Myhrvold , Dennis Rivet , Thomas Weaver , Lowell Wood
IPC: A61B18/18
CPC classification number: A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0088 , A61B5/0091 , A61B5/0097 , A61B5/0507 , A61B5/07 , A61B5/412 , A61B5/4547 , A61B18/20 , A61B18/201 , A61B18/203 , A61B2017/00066 , A61B2018/00208 , A61B2018/00345 , A61B2018/00452 , A61B2018/00505 , A61B2018/00559 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00702 , A61B2018/00785 , A61B2018/00904 , A61B2018/00922 , A61B2018/00982 , A61B2018/20361 , A61B2018/207 , A61N5/0624 , A61N5/1001 , A61N2005/0602 , A61N2005/0606 , A61N2005/0607 , A61N2005/0609 , A61N2005/061 , A61N2005/0644 , A61N2005/0651 , A61N2005/0654 , A61N2005/0659 , A61N2005/0661 , A61N2005/0663 , A61N2005/067 , A61N2005/1087 , A61N2005/1089
Abstract: Apparatus, devices, methods, systems, computer programs and computing devices related to autofluorescent imaging and ablation are disclosed.
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128.发明申请Systems and methods for treating superficial venous malformations like spider veins 有权用于治疗浅静脉畸形的系统和方法，如蜘蛛静脉公开(公告)号：US20070260228A1
公开(公告)日：2007-11-08
申请号：US11446800
申请日：2006-06-05
Applicant: Killian O'Dowd , Anthony Jakubowski , Edward G. Mackay , Aidan Mulloy , Alan A. Creamer , Sherif Sultan
Inventor： Killian O'Dowd , Anthony Jakubowski , Edward G. Mackay , Aidan Mulloy , Alan A. Creamer , Sherif Sultan
IPC: A61B18/18
CPC classification number: A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0644 , A61N2005/0652
Abstract: Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.
Abstract translation: 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布光反应剂例如维替泊芬。 系统和方法通过在激活光反应剂的波长处施加非热光能来激活光反应剂，引起对静脉内壁的局部损伤。
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129.发明申请公开(公告)号：US20070258906A1
公开(公告)日：2007-11-08
申请号：US11600613
申请日：2006-11-16
Applicant: Alan Fischman , Michael Hamblin , Ahmed Tawakol , Tayyaba Hasan , James Muller , Rox Anderson , David Elmaleh
Inventor： Alan Fischman , Michael Hamblin , Ahmed Tawakol , Tayyaba Hasan , James Muller , Rox Anderson , David Elmaleh
IPC: A61K49/00
CPC classification number: A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B6/4258 , A61B18/20 , A61B2017/00057 , A61B2017/00079 , A61B2018/00904 , A61K41/0057 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61K47/643 , A61K51/0474 , A61K51/0491 , A61N5/0601 , A61N5/062 , A61N2005/0602
Abstract: The present invention relates to devices for detection and therapy of active atheromatous plaque and/or thin-capped fibro-atheroma (“vulnerable plaque”), using selectively targeted fluorescent, radiolabeled, or fluorescent and radiolabeled compositions. The present invention further relates to methods and devices for detection and therapy of active atheromatous plaques and/or vulnerable plaques, using selectively targeted beta-emitting compositions, optionally comprising fluorescent compositions.
Abstract translation: 本发明涉及使用选择性靶向荧光，放射性标记或荧光和放射性标记的组合物来检测和治疗活动性动脉粥样硬化斑块和/或薄盖纤维动脉粥样硬化（“易损斑块”）的装置。 本发明还涉及使用选择性靶向的β-发射组合物，任选地包含荧光组合物，用于检测和治疗活动性动脉粥样化斑块和/或易感斑块的方法和装置。
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公开(公告)号：US07252677B2
公开(公告)日：2007-08-07
申请号：US10799357
申请日：2004-03-12
Applicant: Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
Inventor： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC: A61N5/06
CPC classification number: A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
Abstract: Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
Abstract translation: 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。
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