公开(公告)号：US08470010B2

公开(公告)日：2013-06-25

申请号：US12769405

申请日：2010-04-28

申请人： Anthony Jakubowski ,  Aldan Mulloy ,  Edward G. Mackay, II ,  Killian O'Dowd ,  Alan A. Creamer ,  Sherif Sultan

发明人： Anthony Jakubowski ,  Aldan Mulloy ,  Edward G. Mackay, II ,  Killian O'Dowd ,  Alan A. Creamer ,  Sherif Sultan

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.

摘要翻译： 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布反应剂，例如光反应剂如talaporfin钠或维替泊芬。 系统和方法通过施加能量来激活反应剂。 在激活反应剂以引起对静脉内壁的局部损伤的波长处的非热光能。

公开(公告)号：US20100210995A1

公开(公告)日：2010-08-19

申请号：US12769405

申请日：2010-04-28

申请人： Anthony Jakubowski ,  Aldan Mulloy ,  Edward G. Mackay, II ,  Killian O'Dowd ,  Alan A. Creamer ,  Sherif Sultan

发明人： Anthony Jakubowski ,  Aldan Mulloy ,  Edward G. Mackay, II ,  Killian O'Dowd ,  Alan A. Creamer ,  Sherif Sultan

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.

摘要翻译： 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布反应剂，例如光反应剂如塔帕芬钠或维替泊芬。 系统和方法通过施加能量来激活反应剂。 在激活反应剂以引起对静脉内壁的局部损伤的波长处的非热光能。

公开(公告)号：US07465312B2

公开(公告)日：2008-12-16

申请号：US11446800

申请日：2006-06-05

申请人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward George Mackay, II ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

发明人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward George Mackay, II ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.

摘要翻译： 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布光反应剂例如维替泊芬。 系统和方法通过在激活光反应剂的波长处施加非热光能来激活光反应剂，引起对静脉内壁的局部损伤。

公开(公告)号：US20090326435A1

公开(公告)日：2009-12-31

申请号：US12378378

申请日：2009-02-13

申请人： Killian O'Dowd ,  Edward G. Mackay, II ,  Aidan Mulloy

发明人： Killian O'Dowd ,  Edward G. Mackay, II ,  Aidan Mulloy

IPC分类号： A61M37/00

CPC分类号： A61N5/062 ,  A61M37/0092 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as varicose or spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a superficial feeder vein leading to the varicose or spider veins. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the superficial feeder vein to close the feeder vein to interrupt blood flow to the varicose or spider veins, which consequently shrink.

摘要翻译： 系统和方法治疗浅静脉畸形，如静脉曲张或蜘蛛静脉。 系统和方法在表面喂养静脉的内壁处或附近分布反应剂，例如光反应剂如talaporfin钠或维替泊芬，导致静脉曲张或蜘蛛静脉。 系统和方法通过施加能量来激活反应剂。 在激活反应剂的波长处的非热光能量导致对表面进料器静脉的内壁的局部损伤以闭合进料器静脉以中断血液流向静脉曲张或蜘蛛静脉，从而收缩。

公开(公告)号：US08535360B2

公开(公告)日：2013-09-17

申请号：US12313749

申请日：2008-11-24

申请人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward George Mackay, II ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

发明人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward George Mackay, II ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.

公开(公告)号：US20070299431A1

公开(公告)日：2007-12-27

申请号：US11799583

申请日：2007-05-02

申请人： Anthony Jakubowski ,  Aidan Mulloy ,  Edward Mackay ,  Killian O'Dowd ,  Alan Creamer ,  Sherif Sultan

发明人： Anthony Jakubowski ,  Aidan Mulloy ,  Edward Mackay ,  Killian O'Dowd ,  Alan Creamer ,  Sherif Sultan

IPC分类号： A61B18/18

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.

摘要翻译： 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布反应剂，例如光反应剂如塔帕芬钠或维替泊芬。 系统和方法通过施加能量来激活反应剂。 在激活反应剂以引起对静脉内壁的局部损伤的波长处的非热光能。

公开(公告)号：US20090082714A1

公开(公告)日：2009-03-26

申请号：US12313749

申请日：2008-11-24

申请人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward George Mackay, II ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

发明人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward George Mackay, II ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

IPC分类号： A61M37/00 ,  A61N5/06

CPC分类号： A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.

摘要翻译： 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布光反应剂例如维替泊芬。 系统和方法通过在激活光反应剂的波长处施加非热光能来激活光反应剂，引起对静脉内壁的局部损伤。

公开(公告)号：US20070260228A1

公开(公告)日：2007-11-08

申请号：US11446800

申请日：2006-06-05

申请人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward G. Mackay ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

发明人： Killian O'Dowd ,  Anthony Jakubowski ,  Edward G. Mackay ,  Aidan Mulloy ,  Alan A. Creamer ,  Sherif Sultan

IPC分类号： A61B18/18

CPC分类号： A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0644 ,  A61N2005/0652

摘要： Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.

摘要翻译： 系统和方法治疗浅静脉畸形，如蜘蛛静脉。 系统和方法在静脉内壁或其附近分布光反应剂例如维替泊芬。 系统和方法通过在激活光反应剂的波长处施加非热光能来激活光反应剂，引起对静脉内壁的局部损伤。