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公开(公告)号：US20230192681A1
公开(公告)日：2023-06-22
申请号：US17776948
申请日：2020-11-13
Applicant: AMGEN INC.
Inventor： Andrew T. PARSONS , Matthew BEAVER
IPC: C07D471/04 , C07F5/05
CPC classification number: C07D471/04 , C07F5/05
Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2′,2″-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
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公开(公告)号：US11672905B2
公开(公告)日：2023-06-13
申请号：US16951893
申请日：2020-11-18
Applicant: AMGEN INC.
Inventor： Mark A. Destefano , Lawton Laurence , John C. Love , Ian B. Hanson , Paul F. Bente, IV
CPC classification number: A61M5/14248 , A61M5/14244 , A61M5/158 , A61M5/3287 , A61M2005/14252 , A61M2005/1583 , A61M2005/1585 , A61M2205/13 , A61M2205/18 , A61M2205/44 , A61M2205/581 , A61M2205/583 , A61M2207/00
Abstract: An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.
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公开(公告)号：US20230174496A1
公开(公告)日：2023-06-08
申请号：US17918607
申请日：2021-04-27
Applicant: AMGEN INC.
Inventor： Austin G. SMITH , Liang HUANG
IPC: C07D267/18 , C07D513/04 , C07D519/00
CPC classification number: C07D267/18 , C07D513/04 , C07D519/00
Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and R1 are described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
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公开(公告)号：US20230167176A1
公开(公告)日：2023-06-01
申请号：US17921794
申请日：2021-04-28
Applicant: AMGEN INC.
Inventor： Twinkle R. Christian , Bharadwaj Jagannathan
CPC classification number: C07K16/2809 , C07K16/2803 , C07K16/30 , C07K16/2863 , C07K16/2878 , C07K16/2875 , C07K16/28 , A61K47/183 , A61K47/26 , C07K2317/31 , C07K2317/622
Abstract: Described herein are stable high concentration bispecific antibody construct formulations, wherein the formulations have less than 2% high molecular weight species of the bispecific antibody construct in the formulation under storage conditions at various time points.
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公开(公告)号：US20230167130A1
公开(公告)日：2023-06-01
申请号：US17922619
申请日：2021-05-05
Applicant: AMGEN INC.
Inventor： Austin G. SMITH , Jason S. TEDROW , Gabrielle ST-PIERRE , Oliver Ralf THIEL , Liang HUANG , Philipp C. ROOSEN , John T. COLYER , Kyle D. BAUCOM , Ari ERICSON , Matthew G. BEAVER , Rahul P. SANGODKAR , Michael A. LOVETTE , Robert Ronald MILBURN , Alan H. CHERNEY , Sheng CUI
IPC: C07D513/10 , C07D267/16
CPC classification number: C07D513/10 , C07D267/16
Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
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Patent Agency Ranking
公开(公告)号：US20230159510A1
公开(公告)日：2023-05-25
申请号：US17799077
申请日：2021-02-11
Applicant: AMGEN INC.
Inventor： Jennifer Rebecca ALLEN , Albert AMEGADZIE , Diane Jennifer BEYLKIN , Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Michael J. FROHN , Sanne Ormholt Schroder GLAD , Birgitte Weinreich HUSEMOEN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Qingyian LIU , Patricia LOPEZ , Vu Van MA , Francesco MANONI , Jose MEDINA , Ana Elena MINATTI , Jorge PEIRO CADAHIA , Liping PETTUS , Alexander J. PICKRELL , Ian SARVARY , Nuria A. TAMAYO , Mikkel VESTERGAARD
IPC: C07D413/14 , C07D471/04 , C07D401/14 , C07D401/12 , C07D405/14
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salt thereof, stereoisomers, tautomers as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure: (I)
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公开(公告)号：US11643440B2
公开(公告)日：2023-05-09
申请号：US16619874
申请日：2018-06-01
Applicant: AMGEN INC.
Inventor： Irwin Chen , Su Chong , Essa Hu Harrington , Fang-Tsao Hong , Jason C. Long , Leslie P. Miranda
CPC classification number: C07K14/001 , A61P25/06 , A61K38/00
Abstract: Novel peptides that bind to human PAC1 are provided. These peptides that are antagonists of PAC1 are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine, such as acute migraine.
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公开(公告)号：US20230139131A1
公开(公告)日：2023-05-04
申请号：US18089109
申请日：2022-12-27
Applicant: AMGEN INC.
Inventor： Thomas Clark Pearson , Graham F. Milne , Dmitry Fradkin , Erwin Freund
Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.
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公开(公告)号：US20230135301A1
公开(公告)日：2023-05-04
申请号：US17916124
申请日：2021-03-30
Applicant: AMGEN INC.
Inventor： Diogo Ferreira
IPC: G09F3/02
Abstract: A carton closure label is provided. The carton closure includes a first layer having a first adhesion value and a perforated portion extending at least substantially across a dimension of the first layer. The carton closure also includes a second layer removably coupled with the first layer, the second layer having a second adhesion value that is less than the first adhesion value.
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