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公开(公告)号：US20220175782A1
公开(公告)日：2022-06-09
申请号：US17579359
申请日：2022-01-19
Applicant: AMGEN INC.
Inventor： John Gordon ALLEN , Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Jennifer Rebecca ALLEN , Margaret CHU-MOYER , Albert AMEGADZIE , Ning CHEN , Clifford GOODMAN , Jonathan D. LOW , Vu Van MA , Ana Elena MINATTI , Nobuko NISHIMURA , Alexander J. PICKRELL , Hui-Ling WANG , Youngsook SHIN , Aaron C. SIEGMUND , Kevin C. YANG , Nuria A. TAMAYO , Mary WALTON , Qiufen XUE
IPC: A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20200055845A1
公开(公告)日：2020-02-20
申请号：US16661907
申请日：2019-10-23
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , C07D475/00 , C07D275/04 , A61K31/7068 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/519 , A61K31/517 , A61K31/454 , A61K31/55 , A61K31/416 , A61K31/496 , C07D403/04 , C07D237/34 , C07D401/14 , C07D239/80 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04 , C07D417/12 , C07D487/08 , A61K38/07
Abstract: Provided herein are methods of using KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20230159510A1
公开(公告)日：2023-05-25
申请号：US17799077
申请日：2021-02-11
Applicant: AMGEN INC.
Inventor： Jennifer Rebecca ALLEN , Albert AMEGADZIE , Diane Jennifer BEYLKIN , Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Michael J. FROHN , Sanne Ormholt Schroder GLAD , Birgitte Weinreich HUSEMOEN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Qingyian LIU , Patricia LOPEZ , Vu Van MA , Francesco MANONI , Jose MEDINA , Ana Elena MINATTI , Jorge PEIRO CADAHIA , Liping PETTUS , Alexander J. PICKRELL , Ian SARVARY , Nuria A. TAMAYO , Mikkel VESTERGAARD
IPC: C07D413/14 , C07D471/04 , C07D401/14 , C07D401/12 , C07D405/14
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salt thereof, stereoisomers, tautomers as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure: (I)
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Patent Agency Ranking
公开(公告)号：US20220395504A1
公开(公告)日：2022-12-15
申请号：US17363878
申请日：2021-06-30
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20240174660A1
公开(公告)日：2024-05-30
申请号：US18543498
申请日：2023-12-18
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/7068 , A61K38/07 , A61P35/00 , C07D237/34 , C07D239/80 , C07D275/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/12 , C07D471/04 , C07D475/00 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04
CPC classification number: C07D417/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/7068 , A61K38/07 , A61P35/00 , C07D237/34 , C07D239/80 , C07D275/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/12 , C07D471/04 , C07D475/00 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20240050430A1
公开(公告)日：2024-02-15
申请号：US18213464
申请日：2023-06-23
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC classification number: A61K31/517 , A61P35/00 , C07D471/04 , A61K39/39558 , C07D403/04 , A61K31/4985
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20210009577A1
公开(公告)日：2021-01-14
申请号：US17031607
申请日：2020-09-24
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , A61K38/07 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D487/04 , C07D471/04 , C07D401/04 , C07D239/80 , C07D401/14 , C07D237/34 , C07D403/04 , A61K31/496 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/517 , A61K31/519 , A61K31/502 , A61K31/5025 , A61P35/00 , A61K31/7068 , C07D275/04 , C07D475/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20180334454A1
公开(公告)日：2018-11-22
申请号：US15984855
申请日：2018-05-21
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , C07D275/04 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D487/04 , C07D471/04 , C07D401/04 , C07D239/80 , C07D401/14 , C07D237/34 , C07D403/04 , A61K31/496 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/517 , A61K31/519 , A61K31/502 , A61K31/5025 , A61P35/00 , A61K31/7068 , A61K38/07
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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