Patent search ap:("Amgen Inc.") AND inv:"Thomas T. NGUYEN" Page 1

1.

发明申请
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 有权

公开(公告)号：US20220395504A1

公开(公告)日：2022-12-15

申请号：US17363878

申请日：2021-06-30

Applicant: Amgen Inc.

Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN

IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

2.

发明申请
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 有权

公开(公告)号：US20220175782A1

公开(公告)日：2022-06-09

申请号：US17579359

申请日：2022-01-19

Applicant: AMGEN INC.

Inventor： John Gordon ALLEN , Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Jennifer Rebecca ALLEN , Margaret CHU-MOYER , Albert AMEGADZIE , Ning CHEN , Clifford GOODMAN , Jonathan D. LOW , Vu Van MA , Ana Elena MINATTI , Nobuko NISHIMURA , Alexander J. PICKRELL , Hui-Ling WANG , Youngsook SHIN , Aaron C. SIEGMUND , Kevin C. YANG , Nuria A. TAMAYO , Mary WALTON , Qiufen XUE

IPC: A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

3.

发明申请
CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE 审中-公开

公开(公告)号：US20170267673A1

公开(公告)日：2017-09-21

申请号：US15354877

申请日：2016-11-17

Applicant: AMGEN INC.

Inventor： Jennifer R. ALLEN , Albert AMEGADZIE , Matthew P. BOURBEAU , James A. BROWN , Jian J. CHEN , Yuan CHENG , Michael J. FROHN , Angel GUZMAN-PEREZ , Paul E. HARRINGTON , Longbin LIU , Qingyian LIU , Jonathan D. LOW , Vu Van MA , James R. MANNING , Ana Elena MINATTI , Thomas T. NGUYEN , Nobuko NISHIMURA , Mark H. NORMAN , Liping H. PETTUS , Alexander J. PICKRELL , Wenyuan QIAN , Shannon RUMFELT , Robert M. RZASA , Aaron C. SIEGMUND , Markian M. STEC , Ryan D. WHITE , Qiufen XUE

IPC: C07D417/12 , C07D417/14 , C07D471/04 , C07D279/08 , C07D417/04 , C07D513/10

CPC classification number: C07D417/12 , C07D279/08 , C07D417/04 , C07D417/14 , C07D471/04 , C07D513/10

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

4.

发明申请
Cyclopropyl Fused Thiazin-2-Amine Compounds as Beta-Secretase Inhibitors and Methods of Use 有权
Title translation: 环丙基稠合噻嗪-2-胺化合物作为β-分泌酶抑制剂和使用方法

公开(公告)号：US20160046618A1

公开(公告)日：2016-02-18

申请号：US14819256

申请日：2015-08-05

Applicant: AMGEN INC.

Inventor： Jennifer R. ALLEN , Albert AMEGADZIE , Matthew P. BOURBEAU , James A. BROWN , Jian J. CHEN , Yuan CHENG , Michael J. FROHN , Angel GUZMAN-PEREZ , Paul E. HARRINGTON , Longbin LIU , Qingyian LIU , Jonathan D. LOW , Vu Van MA , James MANNING , Ana Elena MINATTI , Thomas T. NGUYEN , Nobuko NISHIMURA , Mark H. NORMAN , Liping H. PETTUS , Alexander J. PICKRELL , Wenyuan QIAN , Shannon RUMFELT , Robert M. RZASA , Aaron C. SIEGMUND , Markian M. STEC , Ryan D. WHITE , Qiufen XUE

IPC: C07D417/12 , C07D471/04 , C07D513/10 , C07D417/14

CPC classification number: C07D417/12 , C07D279/08 , C07D417/04 , C07D417/14 , C07D471/04 , C07D513/10

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract translation: 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。所述化合物具有通式I：其中式I中的变量A4，A5，A6，A8以及R 1，R b，R 1，R 2，R 3和R 7各自独立地定义。本发明还提供包含该化合物的药物组合物，以及该化合物和组合物用于治疗由BACE的生物学活性产生的与A-β斑块形成和沉积有关的病症和/或病症的用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II和III的化合物及其分子式实施方案，用于制备本发明化合物的中间体和方法。

5.

发明申请
AMIDES AS PIM INHIBITORS 有权
Title translation: AMIDES作为PIM抑制剂

公开(公告)号：US20150329538A1

公开(公告)日：2015-11-19

申请号：US14380918

申请日：2013-02-27

Applicant: AMGEN INC.

Inventor： Victor CEE , Frank CHAVEZ, JR. , Jian J. CHEN , Essa Hu HARRINGTON , Bradley HERBERICH , Claire L.M. JACKSON , Brian A. LANMAN , Thomas T. NGUYEN , Mark H. NORMAN , Liping H. PETTUS , Anthony B. REED , Adrian L. SMITH , Nuria A. TAMAYO , Andrew TASKER , Hui-Ling WANG , Bin WU , Ryan WURZ

IPC: C07D471/04 , C07D401/04 , C07D487/04

CPC classification number: C07D471/04 , C07D401/04 , C07D487/04

Abstract: The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

Abstract translation: 本发明涉及式（1）的含酰胺化合物及其盐。在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。

6.

发明公开
KIF18A INHIBITORS 审中-公开

公开(公告)号：US20240254100A1

公开(公告)日：2024-08-01

申请号：US17632333

申请日：2020-08-03

Applicant: AMGEN INC.

Inventor： Nuria A. TAMAYO , Matthew Richard KALLER , Thomas T. NGUYEN , Nobuko NISHIMURA , Qiufen May XUE , John Gordon ALLEN

IPC: C07D401/04 , A61K31/497 , A61K31/5377 , A61K31/541 , C07D241/20 , C07D417/14

CPC classification number: C07D401/04 , A61K31/497 , A61K31/5377 , A61K31/541 , C07D241/20 , C07D417/14

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

7.

发明申请
CYCLOPROPYL FUSED THIAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE 审中-公开

公开(公告)号：US20200231585A1

公开(公告)日：2020-07-23

申请号：US16466199

申请日：2017-12-13

Applicant: AMGEN INC.

Inventor： Jennifer R. ALLEN , Albert AMEGADZIE , Matthew P. BOURBEAU , Jian J. CHEN , Michael J. FROHN , Paul E. HARRINGTON , Jonathan D. LOW , Vu V. MA , Thomas T. NGUYEN , Alexander PICKRELL , Corey REEVES

IPC: C07D417/14 , C07D417/10

Abstract: The present disclosure provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I) wherein variables A, R1, R2, R2′, R3, R4, and R5 of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aβ plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

8.

发明申请
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 审中-公开

公开(公告)号：US20200055845A1

公开(公告)日：2020-02-20

申请号：US16661907

申请日：2019-10-23

Applicant: Amgen Inc.

Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN

IPC: C07D417/04 , C07D475/00 , C07D275/04 , A61K31/7068 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/519 , A61K31/517 , A61K31/454 , A61K31/55 , A61K31/416 , A61K31/496 , C07D403/04 , C07D237/34 , C07D401/14 , C07D239/80 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04 , C07D417/12 , C07D487/08 , A61K38/07

Abstract: Provided herein are methods of using KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

9.

发明申请
AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS 有权

公开(公告)号：US20160176874A1

公开(公告)日：2016-06-23

申请号：US15058023

申请日：2016-03-01

Applicant: AMGEN INC.

Inventor： Jennifer R. ALLEN , Jian J. CHEN , Michael J. FROHN , Matthew R. KALLER , Qingyian LIU , Thomas T. NGUYEN , Alexander J. PICKRELL , Wenyuan QIAN , Robert M. RZASA , Wenge ZHONG

IPC: C07D471/04 , C07D403/14 , C07D401/14

CPC classification number: C07D471/04 , A61K31/497 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14

Abstract: Azetidine and piperidine compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive disorders or diseases treatable by inhibition of PDE10, such as Huntington's Disease, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.