公开(公告)号：US20230257892A1

公开(公告)日：2023-08-17

申请号：US18110050

申请日：2023-02-15

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung Lee ,  Xinghui Liu

IPC: C25B11/093 ,  C25B1/04

CPC classification number: C25B11/093 ,  C25B1/04

Abstract: The present disclosure relates to an electrolysis catalyst including a graphitic carbon layer; and a first metal and a second metal oxide dispersed in the graphitic carbon layer, wherein the first metal is electron-deficient.

公开(公告)号：US11660312B2

公开(公告)日：2023-05-30

申请号：US16621442

申请日：2018-06-14

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sin-Hyeog Im ,  Ravi Verma ,  Changhon Lee

IPC: A61K31/716 ,  A61K35/745 ,  C12N1/20 ,  A61P37/02 ,  A61P37/08 ,  A61P29/00 ,  C08B37/00 ,  C08L5/00

CPC classification number: A61K31/716 ,  A61K35/745 ,  A61P29/00 ,  A61P37/02 ,  A61P37/08 ,  C08B37/0024 ,  C08L5/00 ,  C12N1/205 ,  A23V2200/324 ,  A23Y2300/25 ,  Y10S424/831

Abstract: The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing β-1-6-glucan as an effective ingredient, a probiotic strain producing β-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.

公开(公告)号：US20230151343A1

公开(公告)日：2023-05-18

申请号：US17919588

申请日：2021-04-26

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Kayeong LIM ,  Jaesuk LEE

IPC: C12N9/22

CPC classification number: C12N9/22

Abstract: The present invention relates to a Cas9 variant or a nucleic acid encoding the same, a composition for editing a genome using Cas9 or a Cas9 variant or a nucleic acid encoding the same, and a method of editing a genome using the composition. Specifically, the present invention relates to a composition for editing a genome with excellent efficiency while reducing unwanted insertions/deletions (indels) by using a prime editing nuclease or a variant thereof, for example, Cas9 or a Cas9 variant or a nucleic acid encoding the same, and a method of editing a genome using the composition.

公开(公告)号：US11648525B2

公开(公告)日：2023-05-16

申请号：US17424996

申请日：2020-01-22

Applicant: INSTITUTE FOR BASIC SCIENCE ,  UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Cybulski Olgierd ,  Dygas Miroslaw ,  Mikulak-klucznik Barbara ,  Sobolev Yaroslav ,  Grzybowski Bartosz A

IPC: B01J19/28 ,  B01J19/00

CPC classification number: B01J19/28 ,  B01J19/0053 ,  B01J2219/1943

Abstract: The present invention relates to a reaction method for forming a layered structure of immiscible liquid-phase concentric layers within a rotary reactor and a reaction system including the layered structure, and may provide a basis capable of efficiently performing a multistage reaction in terms of time and space.

公开(公告)号：US20230088084A1

公开(公告)日：2023-03-23

申请号：US17869360

申请日：2022-07-20

Applicant: Research & Business Foundation Sungkyunkwan University ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Sohyeon SEO ,  Jungsue CHOI

IPC: C01B32/05 ,  H01L29/16

Abstract: Disclosed is a method for preparing a graphyne including: supplying a precursor represented by the following Chemical Formula 1 to a chamber including a first zone and a second zone; vaporizing or subliming the precursor in the first zone; and depositing the precursor vaporized or sublimed in the second zone on a metal substrate to form the graphyne: (in Chemical Formula 1, X is carbon or nitrogen, and R1 to R3 may be selected from the group consisting of hydrogen, bromine, fluorine, chlorine, and iodine, respectively).

公开(公告)号：US11498962B2

公开(公告)日：2022-11-15

申请号：US16995707

申请日：2020-08-17

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gou Young Koh ,  Jeomil Bae ,  Mi Jeong Kim ,  Jin-Sung Park ,  Su Jin Seo ,  Jaeryung Kim ,  Jang Ryul Park ,  Pilhan Kim ,  Wangyuhl Oh

IPC: A61K39/395 ,  C07K16/22 ,  A61P35/00 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.

公开(公告)号：US20220355282A1

公开(公告)日：2022-11-10

申请号：US17765738

申请日：2020-09-29

Applicant: Institute For Basic Science ,  Korea Advanced Institute of Science and Technology

Inventor： Ryong Ryoo ,  Jaeheon Kim ,  Changbum Jo ,  Jeongchul Kim

IPC: B01J29/74 ,  B01J23/63 ,  B01J37/02 ,  C07C5/333

Abstract: The composite according to the present invention comprises: a mesoporous inorganic support having vacancy defects; and metal alloy nanoparticles dispersed in and bound to the mesoporous inorganic support and containing a precious metal element and an earth rare element. The composite according to the present invention has a very high specific surface area since the alloy is dispersed and present in the form of ultrafine nanoparticles in the porous support, and thus can show remarkably improved activity when used as a material for a chemical reaction, including a catalyst.

公开(公告)号：US11435505B2

公开(公告)日：2022-09-06

申请号：US16888955

申请日：2020-06-01

Applicant: Research & Business Foundation Sungkyunkwan University ,  Institute for Basic Science

Inventor： Hyun Seok Lee ,  Young Hee Lee

IPC: G02B5/00 ,  G02B6/10 ,  G02B6/122 ,  G02F1/01

Abstract: A wavelength multiplexing device is disclosed. When light is irradiated on a first longitudinal end region of a metal nano-structure, surface plasmon polaritons are generated in the first longitudinal end region. The surface plasmon polaritons and the light are coupled with each other to form first coupled surface plasmon polaritons, wherein the first coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure. When the first coupled surface plasmon polaritons reach a two-dimensional material layer, excitons are induced in the two-dimensional material layer, wherein the induced excitons and the first coupled surface plasmon polaritons are coupled with each other to form second coupled surface plasmon polaritons. The second coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure toward a second longitudinal end thereof.

公开(公告)号：US11419534B2

公开(公告)日：2022-08-23

申请号：US16759277

申请日：2018-10-25

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Taeghwan Hyeon ,  Daehyeong Kim ,  Sangihn Han ,  Suji Choi ,  Dongjun Jung

IPC: A61B5/283 ,  A61N1/05 ,  H01B1/22 ,  H01B5/14 ,  H01B13/00 ,  B22F1/07 ,  B32B5/02 ,  B32B5/26 ,  C30B29/60 ,  B32B15/01 ,  B22F9/20 ,  B22F1/102 ,  B22F1/054 ,  B22F1/17 ,  H01B7/06 ,  A61B5/25 ,  B22F9/24

Abstract: A core-shell nanowire, a method of forming the core-shell nanowire and a stretchable composite comprising the core-shell nanowire are provided. The core-shell nanowire comprises a core comprising a conductive metal and a shell comprising a biocompatible metal. The method of forming the core-shell nanowire comprises a step of forming a core-shell nanowire by carrying out epitaxial growth of a biocompatible metal on a surface of a core comprising a conductive metal. The stretchable composite comprises a first core-shell nanowire/polymer composite comprising first core-shell nanowires and a first polymer, a first insulating layer disposed on the first core-shell nanowire/polymer composite, and a second core-shell nanowire/polymer composite disposed on the first insulating layer and comprising second core-shell nanowires and a second polymer.

公开(公告)号：US11352666B2

公开(公告)日：2022-06-07

申请号：US15526528

申请日：2015-11-13

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin Soo Kim ,  Dae Sik Kim ,  Sang Su Bae

IPC: C12Q1/6874 ,  C12N9/22 ,  C12Q1/686 ,  C12Q1/6806 ,  G16B30/00 ,  G16B30/10

Abstract: The present disclosure relates to a method for detecting off-target sites of a programmable nuclease in a genome, and specifically, to a method for detecting off-target sites through data analysis by subjecting the genome isolated in vitro to programmable nucleases to cleave the genome and then performing whole genome sequencing or deep sequencing, and to a method for selecting on-target sites of a programmable nuclease, which minimizes the off-target effect, using this method. The Digenome-seq of the present disclosure can detect the off-target sites of a programmable nuclease on the genomic scale at a high degree of reproducibility, and thus can be used in the manufacture of programmable nucleases having high target specificity and the study thereof.