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    Ketol fatty acid derivatives and plant growth regulators
    93.
    发明申请
    Ketol fatty acid derivatives and plant growth regulators 有权
    酮醇脂肪酸衍生物和植物生长调节剂

    公开(公告)号：US20050202974A1

    公开(公告)日：2005-09-15

    申请号：US11078335

    申请日：2005-03-14

    Applicant: Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi

    Inventor： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi

    IPC: A01N37/46 ,  A01N43/90 ,  C07C235/76 ,  C07D491/08 ,  A01N57/00 ,  C07D491/02

    CPC classification number: C07D491/08 ,  A01N37/46 ,  A01N43/90 ,  C07C235/76

    Abstract: α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these derivatives: wherein R1 represents linear C1-5 alkyl; R represents hydrogen, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, etc.; R5 represents hydrogen, etc.; n is an integer from 3 to 15; and the carbon atoms at the A- and B-positions may be in either (R)- or (S)-configuration; and wherein R7 represents C1-17 alkyl, etc; R8 represents hydrogen, etc.; R9 represents α-ketolalkylene; and R10 represents specific divalent linear hydrocarbyl.

    Abstract translation: 由下式（1）表示的α-酮醇不饱和脂肪酸衍生物，由下式（6）表示的α-酮醇不饱和脂肪酸酰胺衍生物和含有作为活性成分的至少一种这些衍生物的植物生长调节剂 ：其中R 1表示直链C 1-5烷基; R表示氢等。 R 3表示氢等; R 4表示氢等; R 5表示氢等; n为3〜15的整数， 并且A和B位上的碳原子可以是（R） - 或（S） - 构型; 并且其中R 7表示C 1-17烷基等; R 8表示氢等; R 9表示α-酮醇亚烷基; R 10表示特定的二价直链烃基。

    Flavone acetic acid analogs and methods of use thereof
    95.
    发明申请
    Flavone acetic acid analogs and methods of use thereof 审中-公开
    黄酮乙酸类似物及其使用方法

    公开(公告)号：US20050171138A1

    公开(公告)日：2005-08-04

    申请号：US11091054

    申请日：2005-03-28

    Applicant: Kuo-Hsiung Lee ,  Yi Xia ,  Zheng-Yu Yang ,  Kenneth Bastow ,  Sheng-Chu Kuo

    Inventor： Kuo-Hsiung Lee ,  Yi Xia ,  Zheng-Yu Yang ,  Kenneth Bastow ,  Sheng-Chu Kuo

    IPC: C07D215/22 ,  C07D215/233 ,  A61K31/4741 ,  A61K31/353 ,  A61K31/382 ,  C07D491/02 ,  C07D495/02

    CPC classification number: C07D215/233

    Abstract: Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n is from 1 to 5; R1 and R3 are each independently selected from the group consisting of H, hydroxy, lower alkyl, lower alkoxy, halo, amino, aminoalkyl, nitro, heteroaryl, —OC(═O)R6, —O(C═O)OR6; and —O(C═O)N(R6)2; and R2 is side chain such as an acetic acid side chain, where p is O to 4, R5 is hydroxy, alkoxy or amino, and R6 is H or lower alkyl, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer.

    Abstract translation: 描述具有根据式I或式II的结构的化合物：其中：X选自O，NH和S; Y选自O和S; m为1〜3; n为1〜5; R 1和R 3各自独立地选自H，羟基，低级烷基，低级烷氧基，卤素，氨基，氨基烷基，硝基，杂芳基，-OC （-O）R 6，-O（CO）OR 6; 和-O（C-O）N（R 6）2。 并且R 2是侧链，例如乙酸侧链，其中p为0至4，R 5为羟基，烷氧基或氨基，R 6 或其低级烷基或其药学上可接受的盐。 该化合物可用于治疗癌症。

    Novel 3beta-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof
    100.
    发明申请
    Novel 3beta-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof 有权
    新型3β-氨基偶氮二异辛烷杂芳族酰胺衍生物的制备方法及其治疗用途

    公开(公告)号：US20050080085A1

    公开(公告)日：2005-04-14

    申请号：US10494639

    申请日：2002-10-30

    Applicant: Thierry Imbert ,  Barbara Monse ,  Wouter Koek

    Inventor： Thierry Imbert ,  Barbara Monse ,  Wouter Koek

    IPC: A61K31/46 ,  A61P25/00 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  C07D491/02 ,  A61K31/4741 ,  A61K31/4743 ,  A61K31/498 ,  C07D498/02

    CPC classification number: C07D491/04 ,  C07D495/04

    Abstract: The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a bicyclic fused heteroaromatic, such as thieno[2,3-b]pyridine, furo[2,3-b]pyridine, thieno[3,2-b]pyridine, furo[3,2-b]pyridine, thieno[2,3-b]pyrazine, furo[2,3-b]pyrazine, thieno[2,3-c]pyridine, furo[2,3-c]pyridine, thieno[3,2-c]pyridine and furo[3,2-c]pyridine; R1 represents a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylthio group; R2 represents a linear, branched, cyclic C2-C8 group, a 2- or 3- thienylmethyl group, or a benzyl group optionally substituted by one or several halogens, F, Cl, Br, I, C1-C4 alkyl, C1-C4 alkoxy, CF3, CN, NO2, OH; and their pharmaceutically acceptable salts. Said compounds are anti-dopaminergic agents.

    Abstract translation: 本发明涉及通式1的化合物，其中：A，B，D和E代表一个或两个氮原子，其余是碳原子; X表示S或O，由此形成双环稠合杂芳族化合物，例如噻吩并[2,3-b]吡啶，呋喃并[2,3-b]吡啶，噻吩并[3,2-b]吡啶，呋喃并[ 3,2-b]吡啶，噻吩并[2,3-b]吡嗪，呋喃并[2,3-b]吡嗪，噻吩并[2,3-c]吡啶，呋喃并[2,3-c]吡啶，噻吩并[ 3,2-c]吡啶和呋喃并[3,2-c]吡啶; R1表示直链或支链C1-C6烷氧基，直链或支链C1-C6烷硫基; R 2表示直链，支链，环状的C 2 -C 8基团，2-或3-噻吩基甲基或任选被一个或多个卤素F，Cl，Br，I，C 1 -C 4烷基，C 1 -C 4 烷氧基，CF 3，CN，NO 2，OH; 及其药学上可接受的盐。 所述化合物是抗多巴胺能药。

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