公开(公告)号：US20230241221A1

公开(公告)日：2023-08-03

申请号：US18129508

申请日：2023-03-31

申请人： UroGen Pharma Ltd.

发明人： Asher Holzer ,  Dorit Daniel ,  Michael Mullerad ,  Jaime De La Zerda ,  Uri Shpolansky ,  Nadav Malchi ,  Yosh Dollberg ,  Dor Tal ,  Yossi Yavin ,  Marina Konorty

IPC分类号： A61K47/34 ,  A61K31/407 ,  A61K31/704 ,  A61K31/167 ,  A61K31/7068 ,  A61K31/397 ,  A61K31/07 ,  A61K31/59 ,  A61K31/122 ,  A61K31/337 ,  A61K31/192 ,  A61K38/48 ,  A61K9/00 ,  A61K9/06 ,  A61K47/38 ,  A61K47/10

CPC分类号： A61K47/34 ,  A61K9/06 ,  A61K9/0034 ,  A61K31/07 ,  A61K31/59 ,  A61K31/122 ,  A61K31/167 ,  A61K31/192 ,  A61K31/337 ,  A61K31/397 ,  A61K31/407 ,  A61K31/704 ,  A61K31/7068 ,  A61K38/4893 ,  A61K47/10 ,  A61K47/38

摘要： A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.

公开(公告)号：US11712527B1

公开(公告)日：2023-08-01

申请号：US16847805

申请日：2020-04-14

申请人： Tanya Hamilton

发明人： Tanya Hamilton

IPC分类号： A61M5/42 ,  A61F13/00 ,  A61L15/20 ,  A61L15/24 ,  A61K31/167 ,  A61L15/44

CPC分类号： A61M5/427 ,  A61F13/00063 ,  A61K31/167 ,  A61L15/20 ,  A61L15/24 ,  A61L15/44 ,  A61M5/422 ,  A61L2300/204 ,  A61L2300/402 ,  A61M2205/0238 ,  A61M2205/364

摘要： The kit for locating a vein is configured for use in inserting an intravenous (IV) catheter into a targeted vein of a patient. The kit for locating a vein is a transparent structure. The kit for locating a vein: a) removably attaches to the skin of the patient; b) numbs the skin of the patient; c) generates a vasomotor response; d) provides the ability to insert the IV catheter into the targeted vein while the kit for locating a vein remains attached to the patient; and, e) forms a dressing that captures bodily fluids. The kit for locating a vein comprises a parchment sheeting, a working media, a transparent pocket, and a plurality of apertures. The parchment sheeting, the working media, and the transparent pocket form a transparent composite textile structure. The plurality of apertures are apertures that are formed through the composite textile structure.

公开(公告)号：US20230233520A1

公开(公告)日：2023-07-27

申请号：US17919726

申请日：2021-04-23

申请人： Georgetown University

发明人： Richard Schlegel ,  Hang Yuan

IPC分类号： A61K31/357 ,  A61K31/4045 ,  A61K31/167 ,  A61K9/00 ,  A61P35/00 ,  A61P15/00

CPC分类号： A61K31/357 ,  A61K31/4045 ,  A61K31/167 ,  A61K9/0014 ,  A61P35/00 ,  A61P15/00

摘要： Methods of treating human papillomavirus (HPV)-induced conditions, HPV-induced lesions, or HPV-infected cells. The method involves administering one or more artemisinin-related compounds and one or more histone deacetylase (HDAC) inhibitors. In addition, treatment regimens involving the use of artemisinin-related compounds and HDAC inhibitors, and kits comprising pharmaceutical compositions of artemisinin-related compounds and HDAC inhibitors.

公开(公告)号：US20230233502A1

公开(公告)日：2023-07-27

申请号：US18007153

申请日：2022-01-28

申请人： IMDPHARM INC.

发明人： Young Joon PARK ,  Sook CHOI ,  Ga Haeng LEE ,  Dong Hyun ROH

IPC分类号： A61K31/245 ,  A61K31/167 ,  A61P31/14

CPC分类号： A61K31/245 ,  A61K31/167 ,  A61P31/14

摘要： The present invention relates to a novel cocrystal, a pharmaceutical composition comprising same and a preparation method therefor. By using the cocrystal of the present invention, cancers, inflammatory diseases, or viral infection diseases may be effectively prevented and/or treated.

公开(公告)号：US11708391B2

公开(公告)日：2023-07-25

申请号：US16074300

申请日：2017-02-03

申请人： The Johns Hopkins University

发明人： Jun Liu ,  Jingxin Wang ,  Zufeng Guo

IPC分类号： C07K5/10 ,  C07K5/103 ,  A61P35/00 ,  A61K9/00 ,  A61K31/12 ,  A61K31/167 ,  A61K31/235 ,  A61K31/353 ,  A61K31/407 ,  A61K31/4406 ,  A61K38/12 ,  A61K45/06 ,  C07K5/117 ,  C07K5/12

CPC分类号： C07K5/1008 ,  A61K9/0019 ,  A61K31/12 ,  A61K31/167 ,  A61K31/235 ,  A61K31/353 ,  A61K31/407 ,  A61K31/4406 ,  A61K38/12 ,  A61K45/06 ,  A61P35/00 ,  C07K5/1024 ,  C07K5/12 ,  C07K5/126

摘要： Compounds with the following structures




and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

公开(公告)号：US20230225970A1

公开(公告)日：2023-07-20

申请号：US18022886

申请日：2020-08-26

申请人： CANADIAN NANO PHARMACEUTICAL TECHNOLOGY INC.

发明人： Elham Rahmani Neishaboor

IPC分类号： A61K9/107 ,  A61K31/196 ,  A61K31/167 ,  A61K31/245 ,  A61K31/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/12 ,  A61K47/32 ,  A61K47/18 ,  A61K47/06 ,  A61K9/06 ,  A61K9/00 ,  A61K31/195 ,  A61K31/192 ,  A61K31/197 ,  A61K31/135 ,  A61K36/185 ,  A61K47/44

CPC分类号： A61K9/1075 ,  A61K31/196 ,  A61K31/167 ,  A61K31/245 ,  A61K31/658 ,  A61K47/10 ,  A61K47/14 ,  A61K47/12 ,  A61K47/32 ,  A61K47/183 ,  A61K47/06 ,  A61K9/06 ,  A61K9/0014 ,  A61K31/195 ,  A61K31/192 ,  A61K31/197 ,  A61K31/135 ,  A61K36/185 ,  A61K47/44

摘要： The present disclosure relates to compositions comprising an oil-in-water nano-emulsion dispersed in an external oil phase, methods for the preparation of such compositions as well as uses of such compositions, for example, for delivery of active ingredients to a subject. The methods comprise combining a first mixture comprising a liquid oil and a charged lipid with a second mixture that is an aqueous mixture comprising a film-forming thermoreversible emulsifier to prepare an oil-in-water nano-emulsion; and combining the oil-in-water nano-emulsion with a third mixture comprising a combination of solid lipids to prepare the composition.

公开(公告)号：US20230218553A1

公开(公告)日：2023-07-13

申请号：US18121359

申请日：2023-03-14

申请人： CMPD Licensing, LLC

发明人： Jay Richard Ray, II

IPC分类号： A61K31/196 ,  A61K31/167 ,  A61K47/20 ,  A61P23/02 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06 ,  A61K31/05

CPC分类号： A61K31/196 ,  A61K31/167 ,  A61K47/20 ,  A61P23/02 ,  A61K9/0014 ,  A61K47/10 ,  A61K9/06 ,  A61K31/05

摘要： A method of compounding a topical cream includes combining ingredients including lidocaine hydrochloride, 4%, topical solution, diclofenac sodium, 1.5%, topical solution, lidocaine hydrochloride USP powder, and diclofenac sodium powder.

公开(公告)号：US20230218520A1

公开(公告)日：2023-07-13

申请号：US18013141

申请日：2021-06-24

申请人： LABORATOIRES VIVACY

发明人： Frederic TRANCHEPAIN ,  Florence BRUNEL

IPC分类号： A61K9/06 ,  A61K31/167 ,  A61K47/36

CPC分类号： A61K9/06 ,  A61K31/167 ,  A61K47/36

摘要： A method for incorporating at least one organic compound within a hydrogel, wherein the incorporation is carried out by dialysis, the organic compound being solubilized in the dialysis solution at a concentration equal to or greater than the target concentration.

公开(公告)号：US11690814B2

公开(公告)日：2023-07-04

申请号：US16061572

申请日：2016-11-16

申请人： Conrig Pharma ApS

发明人： John Bondo Hansen ,  Mikael S. Thomsen ,  Niels Skjærbæk

IPC分类号： A61K31/167 ,  A61P11/14 ,  A61K9/00

CPC分类号： A61K31/167 ,  A61K9/0073 ,  A61P11/14

摘要： Provided is a composition comprising suplatast tosilate or pharmaceutically acceptable derivatives thereof for use in a method of treating cough associated with interstitial lung disease, such as cough associated with pulmonary fibrosis.

公开(公告)号：US20230201550A1

公开(公告)日：2023-06-29

申请号：US18001063

申请日：2021-06-04

申请人： Nova Neura, LLC

发明人： David George

IPC分类号： A61M37/00 ,  A61K31/045 ,  A61K31/167 ,  A61K9/00 ,  A61M19/00 ,  A61N1/36

CPC分类号： A61M37/00 ,  A61K31/045 ,  A61K31/167 ,  A61K9/0014 ,  A61M19/00 ,  A61N1/36021 ,  A61M2021/0066

摘要： An applicator can include a dispenser for dispensing an amount of a therapeutic composition, which can include an amount of sugar or sugar alcohol and an amount of an alkalizing agent. In some cases, the alkalizing agent can include L-Arginine. In some cases, 75% or more of the composition by weight has a comedogenicity rating of 3 or less on a scale of 0-5. The dispenser can also have a power supply configured to provide power through a contact tip of the dispenser to provide nerve stimulation, such as using vibration, heating, cooling, and/or electrical stimulation.