知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

102 条记录 (耗时 0.029 秒)

    Glow discharge ion source
    91.
    发明授权
    Glow discharge ion source 有权
    辉光放电离子源

    公开(公告)号：US09500607B2

    公开(公告)日：2016-11-22

    申请号：US14063338

    申请日：2013-10-25

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

    IPC分类号： G01N24/00 ,  H01J49/00 ,  H01J49/10 ,  H01J49/12 ,  H01J49/16 ,  H01J49/04

    CPC分类号： H01J49/12 ,  G01N24/00 ,  H01J49/0009 ,  H01J49/0072 ,  H01J49/0495 ,  H01J49/107 ,  H01J49/165 ,  Y10T436/24

    摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode, which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

    摘要翻译： 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室内的隔离阀内的管状电极。 试剂蒸气可以通过管状电极提供，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉​​光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

    Auxiliary Gas Inlet
    92.
    发明申请
    Auxiliary Gas Inlet 有权
    辅助进气口

    公开(公告)号：US20160336157A1

    公开(公告)日：2016-11-17

    申请号：US15155669

    申请日：2016-05-16

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown ,  Rainer Cramer

    IPC分类号： H01J49/04 ,  H01J49/24 ,  H01J49/16

    CPC分类号： H01J49/0404 ,  H01J49/04 ,  H01J49/0418

    摘要： There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a Matrix Assisted Laser Desorption Ionisation (“MALDI”) ion source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.

    摘要翻译： 提供了将离子引入质谱仪的方法，其包括使用基质辅助激光解吸电离（“MALDI”）离子源离子化样品以形成多个离子，将第一主气体中的所述多个离子输送通过 通道并进入质谱仪的入口，将第二辅助气体引入所述入口，并且将所述第二气体的流量控制到所述入口中，以控制所述第一气体通过所述通道的流量。

    Methods for the analysis of glycoproteins or glycopeptides by mass spectrometry
    93.
    发明授权
    Methods for the analysis of glycoproteins or glycopeptides by mass spectrometry 有权
    通过质谱分析糖蛋白或糖肽的方法

    公开(公告)号：US09255906B2

    公开(公告)日：2016-02-09

    申请号：US14049652

    申请日：2013-10-09

    申请人： Micromass UK Limited

    发明人： Jonathan P. Williams ,  Jeffery Mark Brown

    IPC分类号： G01N33/68 ,  G01N27/62 ,  G01N30/72 ,  H01J49/00

    CPC分类号： G01N27/62 ,  G01N30/7233 ,  G01N33/6848 ,  H01J49/004

    摘要： A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing the chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptides ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction mass spectral data to provide structural information relating to the glycopeptide.

    摘要翻译： 一种用于分析包括一种或多种糖肽的样品的方法，包括以下步骤：使用色谱系统分离一种或多种糖肽以产生色谱洗脱液，向色谱洗脱液中加入增量试剂，将色谱洗脱液和增量试剂提供至质量 在离子源中离子化色谱洗脱液和增压剂以产生糖肽离子，对至少一些糖肽离子进行至少一个离子离子反应以产生碎片离子，大量分析碎片离子以产生离子离子反应质谱 数据，并解释离子反应质谱数据，以提供与糖肽有关的结构信息。

    Mass spectrometer
    96.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US09117644B2

    公开(公告)日：2015-08-25

    申请号：US14330373

    申请日：2014-07-14

    申请人： Micromass UK Limited

    发明人： Martin Raymond Green ,  Jason Lee Wildgoose ,  Jeffery Mark Brown

    IPC分类号： H01J49/26 ,  H01J49/40 ,  H01J49/04 ,  H01J49/00 ,  H01J49/06

    CPC分类号： H01J49/0481 ,  H01J49/0072 ,  H01J49/065 ,  H01J49/40 ,  Y10T436/24

    摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.

    摘要翻译： 公开了一种质谱仪，其包括电子转移解离单元。 当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。 电池包括形成球形捕获体积的多个环形电极。 在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。 从而提供具有增强的灵敏度的电子转移解离电池。 在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

    Method of MS/MS Mass Spectrometry
    98.
    发明申请
    Method of MS/MS Mass Spectrometry 有权
    MS / MS质谱法

    公开(公告)号：US20150144780A1

    公开(公告)日：2015-05-28

    申请号：US14401415

    申请日：2013-05-16

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0054 ,  H01J49/0031 ,  H01J49/0072

    摘要： A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to Electron Capture Dissociation (“ECD”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure.

    摘要翻译： 公开了一种质谱方法，其包括在母体离子质量分析的第一模式和母体离子在大气压下进行电子俘获解离（“ECD”）的第二模式之间交替，以产生碎片离子，其中 然后进行质量分析。 基于它们被检测的时间，母体离子与它们的碎片离子相关联。 这种方法使得母体离子与其碎片离子相关联，即使当在大气压下进行ECD断裂时。

    Method of MS Mass Spectrometry
    99.
    发明申请
    Method of MS Mass Spectrometry 有权
    MS质谱法

    公开(公告)号：US20150090875A1

    公开(公告)日：2015-04-02

    申请号：US14401346

    申请日：2013-05-16

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown ,  Martin Raymond Green

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0045 ,  H01J49/0031

    摘要： A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are analysed and a second mode in which parent ions are fragmented and their fragment ions are mass analysed. In the first mode the parent ions are charge reduced before being analysed, so as to simplify the parent ion spectral data obtained. In the second mode, the parent ions are not charge reduced prior to fragmentation, so that it remains relatively easy to induce the parent ions to fragment. The parent ions are then associated with their fragment ions using the mass spectral data obtained.

    摘要翻译： 公开了一种质谱法，其包括在其中分析母体离子的第一模式和其中母体离子被分裂并且其碎片离子被质量分析的第二模式之间交替。 在第一种模式下，母体离子在分析之前进行电荷减少，从而简化获得的亲本离子光谱数据。 在第二种模式中，母体离子在分裂之前不是电荷还原，因此保持相对容易诱导母体离子分裂。 然后使用获得的质谱数据将母体离子与其片段离子相关联。

    Mass Spectrometer
    100.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20140322817A1

    公开(公告)日：2014-10-30

    申请号：US14330373

    申请日：2014-07-14

    申请人： Micromass UK Limited

    发明人： Martin Raymond Green ,  Jason Lee Wildgoose ,  Jeffery Mark Brown

    IPC分类号： H01J49/04 ,  H01J49/40

    CPC分类号： H01J49/0481 ,  H01J49/0072 ,  H01J49/065 ,  H01J49/40 ,  Y10T436/24

    摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.

    摘要翻译： 公开了一种质谱仪，其包括电子转移解离单元。 当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。 电池包括形成球形捕获体积的多个环形电极。 在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。 从而提供具有增强的灵敏度的电子转移解离电池。 在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。