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91.发明公开公开(公告)号：US20240286178A1
公开(公告)日：2024-08-29
申请号：US18408268
申请日：2024-01-09
申请人： Protein Evolution Inc. , PARIS SCIENCES ET LETTRES , Centre National de la Recherche Scientifique , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
发明人： Ludwik Leibler , François Tournilhac , Clément Freymond , Hernan Garate , Louise Bréloy , Andrew Griffiths , Yannick Rondelez , Brian Mansaku , Jack Pallis , Benjamin Gibbs
CPC分类号： B09B3/60 , C12N9/18 , C12Y301/01074
摘要： Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some cases, the methods further comprise a thermal annealing step following the step of reacting the polymeric material comprising the crystallizable polymer or copolymer with the reactive agent and prior to the step of exposing the pretreated polymeric material to the polymer-degrading enzyme. During the thermal annealing step, further chain reactions (e.g., chain scission, extension, branching, and/or cross-linking) may occur.
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公开(公告)号：US11950919B2
公开(公告)日：2024-04-09
申请号：US16766087
申请日：2018-11-21
申请人： Paris Sciences Et Lettres—Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris , Sorbonne Universite
CPC分类号： A61B5/374 , A61B5/377 , A61B5/7246 , A61B5/7267
摘要： The invention concerns a method for calibrating a system for real-time measurement of the activity of a cognitive function of a test subject, the method comprising the successive steps of: acquiring electrical signals representative of a neural activity of a test subject; calculating values of markers of the cognitive function activity; generating a plurality of copies of calculated values of markers and adding noise to the generated copies; and, constructing a classifier by machine learning, based on the calculated marker values and noisy copies, the classifier being suitable for measuring the activity of the cognitive function of the test subject by calculating a probability that an electrical signal representative of the neural activity of the test subject results from a predetermined activity state of the cognitive function of the test subject.
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公开(公告)号：US20240082842A1
公开(公告)日：2024-03-14
申请号：US18260899
申请日：2022-01-12
申请人： PARIS SCIENCES ET LETTRES , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MICROFACTORY SAS
发明人： Hubert GEISLER , Patrick TABELING , Andrew GRIFFITHS , Stéphane CHIRON , Fabrice MONTI , Gaël BLIVET-BAILLY , Marjan ABDORAHIM , Yvette TRAN-AMARELIS , Phillipe NGHE
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502707 , B01L2200/0647 , B01L2200/12 , B01L2300/069 , B01L2300/12
摘要： A microfluidic device comprising: —a first wall comprising a first substrate on which a plurality of closed patterns is grafted, —a second wall, facing the first wall, comprising a second substrate, —a plurality of nucleic acids grafted either on the first substrate or on the second substrate, wherein each nucleic acid comprises a barcode that encodes the position of the nucleic acid on said first or second substrate, wherein at least the plurality of closed patterns or the second substrate is made of an actuatable hydrogel which is swellable between a retracted state and a swollen state in which the closed patterns and the second substrate come into contact.
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公开(公告)号：US20240009329A1
公开(公告)日：2024-01-11
申请号：US18248612
申请日：2021-10-07
申请人： PARIS SCIENCES ET LETTRES , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSIDADE ESTADUAL DE CAMPINAS , FACULDADES CATOLICAS ASSOCIACAO SEM FINS LUCRATIVOS, MANTENEDORA DA PONTIFICIA UNIVERSIDADE CATOLICA
发明人： Ugur SOYSAL , Pedro NIECKELE AZEVEDO , Patrick TABELING , Lucimara GAZIOLA DE LA TORRE , Amanda COSTA SILVA NORONHA PESSOA , Marcio DA SILVEIRA CARVALHO , Elian MARTIN
CPC分类号： A61K49/223 , A61K9/19 , A61K9/5089 , B01J13/04
摘要： The present invention to freeze-dried monodisperse microbubbles. The invention also relates to a process for preparing said microbubbles using microfluidic techniques. The microbubbles according to the present invention show interesting properties, making them particularly useful in applications that require monodispersity of the microbubbles.
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公开(公告)号：US11843444B2
公开(公告)日：2023-12-12
申请号：US17414385
申请日：2019-12-17
申请人： Centre national de la recherche scientifique , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , ORANGE SA
CPC分类号： H04B7/10 , H04B1/1081 , H04W24/02
摘要： The present invention relates to an ambient backscattering communication system (14), the communication system (14) comprising:
an ambient backscattering transmitter (16) suitable for generating an ambient backscattering signal according to a first polarization from an ambient signal incident on the transmitter (16),
an ambient backscattering receiver (18) suitable for detecting the ambient backscattering signal transmitted by the ambient backscattering transmitter according to a second polarization, and
a reduction device (22) for reducing the interference between the ambient backscattering signal and an ambient signal incident on the receiver, the reduction device (22) controlling the first polarization and the second polarization
and wherein at least one of said first and second polarizations is adjustable.-
公开(公告)号：US11680074B2
公开(公告)日：2023-06-20
申请号：US17570040
申请日：2022-01-06
申请人： ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Ludwik Leibler , Renaud Nicolay
CPC分类号： C07F5/025 , C07F7/1872 , C08G79/08
摘要： The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R′3 or R4 is a radical of formula —X; or one of R1, R2, R3, R′3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
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公开(公告)号：US20230032690A1
公开(公告)日：2023-02-02
申请号：US17818481
申请日：2022-08-09
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE LILLE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
发明人： Luc BUEE , Malika HAMDANE , David BLUM , Maxime DERISBOURG , Coline LEGHAY , Giovanni CHIAPPETTA , Joelle VINH , Yann VERDIER
摘要： The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated. The invention also relates to antibody that specifically binds this new tau species, a method of detection of this new Tau species and a method of diagnosis of Tauopathy disorder.
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公开(公告)号：US20220407234A1
公开(公告)日：2022-12-22
申请号：US17777274
申请日：2020-11-26
申请人： THALES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
摘要： A radiating element of an antenna includes at least one wire-like nanostructure, each wire-like nanostructure extending in the same direction, called common direction, between a first end and a second end, and an inductor connected to each first end of a nanostructure, the inductor being formed from a first conductive material, the inductor extending in a plane normal to the common direction, the first conductive material having an electrical conductivity that varies under the effect of a variation of an electric field applied within the first conductive material.
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公开(公告)号：US20220347690A1
公开(公告)日：2022-11-03
申请号：US17839589
申请日：2022-06-14
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
发明人： Jean BAUDRY , Jérôme BIBETTE , Laurent BOITARD , Klaus EYER , Krzysztof LANGER
IPC分类号： B01L3/00 , C12Q1/6804 , G01N15/14 , G01N33/50
摘要： The present invention relates to a method for selecting and recovering products, including providing an emulsion (6) comprising a plurality of drops (4) contained in a carrier fluid (10), each drop comprising an internal fluid (8), measuring at least one physical parameter for several drops (4) of the emulsion (6), classifying at least some of the drops (4) of the emulsion in a class based on measurements obtained during measuring, tagging at least some of the classified drops (4) based on the class of the drop (4), and selectively recovering the drop (4) or part of the drop (4) using the tag of the drop or part of the drop (4).
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公开(公告)号：US20220341479A1
公开(公告)日：2022-10-27
申请号：US17262402
申请日：2019-07-22
申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITÉ , UNIVERSITÉ DE PARIS
发明人： Emmanuel SIEFERT , Benoît ROMAN , José BICO , Etienne REYSSAT
IPC分类号： F16F9/04
摘要： Pneumatic Structure and Associated Production Method
The structure (10) comprises an elastically deformable body (12) defining at least one network of internal cavities (14), each internal cavity (14) having a closed contour in at least one section of the internal cavity (14),
Each internal cavity (14) is able to be pressurized so as to make the elastically deformable body (12) pass from a rest configuration to at least one pressurized configuration,
In each pressurized configuration, the elastically deformable body (12) has a macroscopic metric that is distinct from its macroscopic metric in the rest position,
In each pressurized configuration, the radius of curvature of an outer surface of the elastically deformable body (12), considered regarding each internal cavity (14) adjacent to the outer surface, is greater than twice the size of the internal cavity (14) adjacent to the outer surface.
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