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91.
公开(公告)号:US20180148728A1
公开(公告)日:2018-05-31
申请号:US15540611
申请日:2015-12-31
Inventor: Pyung Cheon LEE , Bo Hyun CHOI , Sun Hyoung CHOI
CPC classification number: C12N15/70 , C12N9/001 , C12N9/0073 , C12N9/1048 , C12N9/1085 , C12N9/90 , C12N15/01 , C12P23/00 , C12Y103/9903 , C12Y114/13129 , C12Y205/01001 , C12Y205/01032 , C12Y505/01019
Abstract: Provided is a mutant having an ability to overproduce carotenoids and a method for producing carotenoids by using the mutant. The mutant, of which mutations are induced by irradiation after being transformed with a recombinant vector according to the subject matter, has an excellent ability to produce carotenoids and can be mass-produced, and thus can be useful in various industrial fields, which use carotenoids, such as cosmetics, food, and feed.
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公开(公告)号:US20180148455A1
公开(公告)日:2018-05-31
申请号:US15578086
申请日:2015-12-23
Inventor: Sang Dun CHOI , Prasannavenkatesh DURAI , Asma ACHEK
IPC: C07D487/04 , C07D409/12 , C07D211/26 , C07D243/08 , C07C251/24 , C07D265/30 , C07D401/12 , C07D471/10 , C07D211/34 , C07D401/14 , C07D403/06 , C07D403/12 , C07D401/06 , C07D333/78 , C07D207/277 , C07D471/04 , A61P7/00 , A61P17/00 , A61P37/08 , A61P11/06 , A61P27/02 , A61P1/02 , A61P27/00 , A61P27/16 , A61P1/00 , A61P31/12 , A61P11/00 , A61P1/04 , A61P19/06 , A61P19/02 , A61P29/00 , A61P13/12 , A61P25/28
CPC classification number: C07D487/04 , A61K9/0053 , A61K31/4178 , A61K31/4453 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P1/00 , A61P1/02 , A61P1/04 , A61P7/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P19/06 , A61P25/28 , A61P27/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/12 , A61P37/08 , C07C251/24 , C07D207/277 , C07D211/26 , C07D211/34 , C07D243/08 , C07D265/30 , C07D333/78 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D409/12 , C07D471/04 , C07D471/10
Abstract: The present disclosure relates to a novel small molecule TLR2 antagonist, and particularly, to 19 novel TLR2 antagonists, a pharmaceutical composition, including the antagonists, for preventing or treating inflammatory diseases, and a TLR4 regulator.The novel TLR2 antagonists according to the present disclosure can be effectively used as a preparation for oral administration by having low molecular weight and high oral bioavailability, and can be useful in pharmaceutical compositions for preventing or treating inflammatory diseases since the secretion of IL-8 is effectively inhibited and in vivo cytotoxicity is not induced. In addition, the novel TLR2 antagonists according to the present disclosure can be used as a TLR4 regulator.
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公开(公告)号:US20180144534A1
公开(公告)日:2018-05-24
申请号:US15821981
申请日:2017-11-24
Inventor: Kyung Won LEE , Hyo Ji HA , Hyun Woo HAN , Sung Yun BAE , Ji Hye LEE , Chang Hyung HONG , Sang Joon SON , Hyun Jung SHIN
IPC: G06T15/00
CPC classification number: G06T15/00 , G06F16/00 , G06K9/6218 , G06T11/206 , G06T19/00 , G16H50/70
Abstract: Provided is a method of visualizing a plurality of nodes respectively including a plurality of variable values for a data object. The method includes: allocating a predetermined upper limit value and a predetermined lower limit value for each of a plurality of variables to vertices of a three-dimensional polygon facing each other; respectively determining partial positions related to the variables for the nodes based on the upper limit value and the lower limit value for each of the variables, a maximum variable value and a minimum variable value for each variable from among variable values of the nodes, and the variable values of the nodes; respectively determining final positions of the nodes in the three-dimensional polygon based on the determined partial positions; and arranging the nodes in the three-dimensional polygon according to the determined final positions.
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公开(公告)号:US09980150B2
公开(公告)日:2018-05-22
申请号:US15048070
申请日:2016-02-19
Inventor: Jae Bum Kim , Ji Na Han , Young Bae Ko
Abstract: A node device using a TV white space (TVWS) includes a decision unit for comparing energy levels of a first sub-channel and at least one second sub-channel adjacent to the first sub-channel among a plurality of sub-channels with respect to a digital TV (DTV) channel including the plurality of sub-channels and deciding whether the DTV channel is an available channel, and a discovery unit for, if the DTV channel is decided as the available channel, discovering a beacon by scanning the first sub-channel in the DTV channel.
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公开(公告)号:US20180093892A1
公开(公告)日:2018-04-05
申请号:US15819576
申请日:2017-11-21
Inventor: Kyung-sang CHO , Sang-wook KIM , Tae-ho KIM , Dong-hyeok CHOI , Byoung-lyong CHOI
CPC classification number: C01B17/20 , B82Y30/00 , B82Y40/00 , C01B19/002 , C01B19/007 , C01G1/12 , C01G11/02 , C01P2002/86 , C01P2004/64 , C01P2004/84 , C01P2006/90
Abstract: Provided are nanoparticles passivated with a cationic metal-chalcogenide complex (MCC) and a method of preparing the same. A passivated nanoparticle includes: a core nanoparticle; and a cationic metal-chalcogenide compound (MCC) fixed on a surface of the core nanoparticle
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96.
公开(公告)号:US20180051064A1
公开(公告)日:2018-02-22
申请号:US15560232
申请日:2016-03-23
Inventor: Yong Sung KIM , Ye Jin KIM
IPC: C07K14/705 , A61K9/127 , G01N33/574 , G01N33/68
CPC classification number: C07K14/705 , A61K9/127 , A61K38/00 , A61K47/50 , C07K19/00 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2319/30 , G01N33/53 , G01N33/57492 , G01N33/6845 , G01N33/6872 , G01N33/6893 , G01N2333/70596 , G01N2800/7014
Abstract: A peptide that binds specifically to neuropilin-1 (NRP1) without binding to neuropilin-2 (NRP2) is provided. A fusion protein, a fusion antibody, small-molecule drug, a nanoparticle, or a liposome, which comprises the peptide, and a pharmaceutical composition for treating or preventing cancer or angiogenesis-related diseases, and a composition for diagnosing cancer or angiogenesis-related diseases are provided. A polynucleotide encoding the peptide that binds specifically to NRP1 and a method for screening the peptide that binds specifically to NRP1 are provided. An antibody heavy-chain constant region Fc-fused peptide binding specifically to NRP1 has the property of binding specifically to NRP1, and thus when it is administered in vivo, it accumulates selectively in tumor tissue, and widens the intercellular space between tumor-associated endothelial cells to promote its extravasation and increases its tumor tissue penetration.
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公开(公告)号:US09897920B2
公开(公告)日:2018-02-20
申请号:US14645009
申请日:2015-03-11
Inventor: Yunhee Ku , Moosub Kim , Yongju Yang , Seung Yeon Song , Kang Sun Lee , Hyun Chul Yoon , Yong Duk Han , Yoo Min Park
CPC classification number: G03F7/2002 , G01N21/78 , G01N2400/00 , G03F7/027
Abstract: The present disclosure relates to a sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same wherein the sensor for detecting saccharide includes a reactive layer synthesized with hydrogel having a boronic acid-modified 3D mesh structure. A selective and sensitive detection of the glycated protein including glucose or glycated hemoglobin (HbA1c) in blood through high level of signal may be enabled, and the durability of the sensor for detecting saccharide may be enhanced.
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公开(公告)号:US20180045695A1
公开(公告)日:2018-02-15
申请号:US15790837
申请日:2017-10-23
Inventor: Yong Gyu Noh , Se Kwon Jung , Chi Myung Kim , Hyung Tak Seo , Yeong An Lee
IPC: G01N31/10
CPC classification number: G01N31/10
Abstract: A hydrogen sensor and a method for manufacturing the same are provided. The hydrogen sensor includes a metal oxide layer formed over a substrate, and a catalytic pattern that is formed over the metal oxide layer. Further, a protective layer is formed over the catalytic pattern.
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公开(公告)号:US20180037869A1
公开(公告)日:2018-02-08
申请号:US15554849
申请日:2016-03-04
Inventor: Hae Young Suh , Sung Soo Kim , Da Young Chang , Jin Hwa Jung , Young Don Lee , Woo Sup Hwang , Jin Sung Park , Su Jung Lee
IPC: C12N5/0775 , A61K31/513 , A61K45/06 , A61K35/28
CPC classification number: C12N5/0665 , A61K31/4188 , A61K31/4745 , A61K31/506 , A61K31/513 , A61K31/675 , A61K31/704 , A61K33/24 , A61K35/12 , A61K35/28 , A61K45/06 , C12N5/0663 , C12N2501/73 , C12N2510/00 , C12N2523/00
Abstract: The present disclosure relates to a method for preparing cells for cancer treatment and a kit for cancer treatment comprising cells prepared by the method. The preparation method of the present disclosure can provide F cells, which, in spite of having no difference in the proliferative capacity compared with mesenchymal stem cells expressing cytosine deaminase that are harvested and used immediately after the culture, exhibit a very excellent tumor suppressive effect through the treatment together with 5-FC and induce a remarkable synergistic effect exceeding an effect from combinative treatment with an existing anticancer drug in cases of a combinative treatment with another anticancer drug. Therefore, the present disclosure can be utilized for a kit for cancer treatment comprising such F cells, and thus can be favorably used to maximize the effect of existing cancer treatments.
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公开(公告)号:US09887464B2
公开(公告)日:2018-02-06
申请号:US15171670
申请日:2016-06-02
Inventor: Ikmo Park , Tran Huy Hung
CPC classification number: H01Q9/285 , H01Q1/2225 , H01Q1/36 , H01Q1/38 , H01Q21/24
Abstract: Provided is a compact dipole antenna for a radio frequency identification (RFID) tag. The antenna includes a substrate, a dipole radiator including a first dipole element and a second dipole element, in each of which a first meander line formed in a meandering shape and an arm configured of a triangular pattern which is an end connected to the first meander line, are arranged to face each other, wherein the first and second dipole elements are arranged on the substrate to be perpendicular to each other, and an impedance matcher, which includes a second meander line formed in a meandering shape, is formed at a point at which the first and second dipole elements are perpendicular to each other, and performs an impedance matching between the antenna and an RFID tag chip through the second meander line.
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