公开(公告)号：US20180037869A1

公开(公告)日：2018-02-08

申请号：US15554849

申请日：2016-03-04

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hae Young Suh ,  Sung Soo Kim ,  Da Young Chang ,  Jin Hwa Jung ,  Young Don Lee ,  Woo Sup Hwang ,  Jin Sung Park ,  Su Jung Lee

IPC: C12N5/0775 ,  A61K31/513 ,  A61K45/06 ,  A61K35/28

CPC classification number: C12N5/0665 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/513 ,  A61K31/675 ,  A61K31/704 ,  A61K33/24 ,  A61K35/12 ,  A61K35/28 ,  A61K45/06 ,  C12N5/0663 ,  C12N2501/73 ,  C12N2510/00 ,  C12N2523/00

Abstract: The present disclosure relates to a method for preparing cells for cancer treatment and a kit for cancer treatment comprising cells prepared by the method. The preparation method of the present disclosure can provide F cells, which, in spite of having no difference in the proliferative capacity compared with mesenchymal stem cells expressing cytosine deaminase that are harvested and used immediately after the culture, exhibit a very excellent tumor suppressive effect through the treatment together with 5-FC and induce a remarkable synergistic effect exceeding an effect from combinative treatment with an existing anticancer drug in cases of a combinative treatment with another anticancer drug. Therefore, the present disclosure can be utilized for a kit for cancer treatment comprising such F cells, and thus can be favorably used to maximize the effect of existing cancer treatments.