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公开(公告)号：US08846388B2
公开(公告)日：2014-09-30
申请号：US13501371
申请日：2010-04-16
Applicant: Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
Inventor： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
CPC classification number: A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C07K2317/33 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/10021 , C12N2750/10034
Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
Abstract translation: 本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。
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公开(公告)号：US09897605B2
公开(公告)日：2018-02-20
申请号：US14946384
申请日：2015-11-19
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Xiang-Jin Meng , Yaowei Huang
IPC: G01N33/569 , C07K16/08 , C12Q1/70 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
Abstract: The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
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3.发明申请REARRANGED TT VIRUS MOLECULES FOR USE IN DIAGNOSIS, PREVENTION AND TREATMENT OF CANCER AND AUTOIMMUNITY 有权用于诊断，预防和治疗癌症和自身免疫的TT疫苗分子公开(公告)号：US20170066802A9
公开(公告)日：2017-03-09
申请号：US13719835
申请日：2012-12-19
Applicant: Deutsches Krebsforschungszentrum
Inventor： Ethel-Michele De Villiers , Harald Zur Hausen
IPC: C07K14/01 , C12N15/113 , C12Q1/70 , C07K16/08 , G01N33/569
CPC classification number: C07K14/01 , C07K14/005 , C07K16/081 , C12N7/00 , C12N15/1131 , C12N2750/00021 , C12N2750/00022 , C12Q1/6883 , C12Q1/6886 , C12Q1/701 , G01N33/56983 , G01N2800/50
Abstract: The present invention relates to rearranged molecules of (a) a specific TT virus sequence and (b) a nucleotide sequence encoding a polypeptide showing homology to mammalian proteins associated with cancer and autoimmune diseases that are capable of replicating autonomously for use in diagnosis, prevention and treatment of diseases like cancer and autoimmunity.
Abstract translation: 本发明涉及（a）特定TT病毒序列的重排分子和（b）编码与癌症和自身免疫疾病相关的哺乳动物蛋白质具有同源性的多肽的核苷酸序列，其能够自主复制以用于诊断，预防和 治疗癌症和自身免疫等疾病。
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公开(公告)号：US20160216263A1
公开(公告)日：2016-07-28
申请号：US14946384
申请日：2015-11-19
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Xiang-Jin MENG , Yaowei Huang
IPC: G01N33/569
CPC classification number: G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
Abstract: The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
Abstract translation: 本发明提供了含有编码猪扭转腱病毒（PTTV）基因型或亚型PTTV1a-VA，PTTV1b-VA，PTTV2b-VA和PTTV2c-VA的多核酸分子的四种纯化制剂。 本发明还提供含有感染性核酸基因组分子的感染性DNA克隆，生物功能质粒或病毒载体。 本发明进一步提供活的，减毒的载体表达和纯化的重组衣壳亚单位或灭活的病毒疫苗以防止PTTV感染。 本发明另外提供了包含PTTV特异性基因产物的亚单位疫苗，特别是用于保护免受PTTV感染的ORF1衣壳基因产物。 此外，本发明提供了使用PTTV1，PTTV2和个体PTTV1基因型的特异性引物通过聚合酶链反应（PCR）诊断PTTV感染的方法。 最后，本发明提供了通过免疫学方法诊断PTTV感染的方法，例如使用PTTV特异性抗原检测血清PTTV特异性抗体的酶联免疫吸附测定（ELISA）和蛋白质印迹。
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公开(公告)号：US20110045019A1
公开(公告)日：2011-02-24
申请号：US12861378
申请日：2010-08-23
Applicant: XIANG-JIN MENG , YAOWEI HUANG
Inventor： XIANG-JIN MENG , YAOWEI HUANG
CPC classification number: G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
Abstract: The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
Abstract translation: 本发明提供了含有编码猪扭转腱病毒（PTTV）基因型或亚型PTTV1a-VA，PTTV1b-VA，PTTV2b-VA和PTTV2c-VA的多核酸分子的四种纯化制剂。 本发明还提供含有感染性核酸基因组分子的感染性DNA克隆，生物功能质粒或病毒载体。 本发明进一步提供活的，减毒的载体表达和纯化的重组衣壳亚单位或灭活的病毒疫苗以防止PTTV感染。 本发明另外提供了包含PTTV特异性基因产物的亚单位疫苗，特别是用于保护免受PTTV感染的ORF1衣壳基因产物。 此外，本发明提供了使用PTTV1，PTTV2和个体PTTV1基因型的特异性引物通过聚合酶链反应（PCR）诊断PTTV感染的方法。 最后，本发明提供了通过免疫学方法诊断PTTV感染的方法，例如使用PTTV特异性抗原检测血清PTTV特异性抗体的酶联免疫吸附测定（ELISA）和蛋白质印迹。
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Patent Agency Ranking
公开(公告)号：US07416842B2
公开(公告)日：2008-08-26
申请号：US10819098
申请日：2004-04-05
Applicant: Thomas H. Tuschl , Sebastien Pfeffer
Inventor： Thomas H. Tuschl , Sebastien Pfeffer
CPC classification number: C12N15/86 , C12N7/00 , C12N2750/00021 , C12N2750/00043
Abstract: The invention relates to isolated nucleic acid molecules comprising the sequence of a DNA virus microRNA. In another embodiment, the invention relates to single stranded DNA virus microRNA molecules. In yet another embodiment, the invention relates to single stranded anti-DNA virus microRNA molecules.
Abstract translation: 本发明涉及包含DNA病毒微小RNA序列的分离的核酸分子。 在另一个实施方案中，本发明涉及单链DNA病毒微RNA分子。 在另一个实施方案中，本发明涉及单链抗DNA病毒微小RNA分子。
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公开(公告)号：US20240000914A1
公开(公告)日：2024-01-04
申请号：US18250621
申请日：2021-10-29
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Simon DELAGRAVE , Fernando Martin DIAZ , Jared David PITTS , Kevin James LEBO , Joseph Louis TIMPONA , Nicole Marie BOISVERT
CPC classification number: A61K39/12 , C12N7/00 , C12N15/86 , C12N1/04 , C12N2750/00021 , C12N2750/00023 , C12N2750/00034 , C12N2750/00043 , A61K2039/5256
Abstract: This invention relates generally to compositions for making C A Vectors and uses thereof.
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公开(公告)号：US20230348933A1
公开(公告)日：2023-11-02
申请号：US18009557
申请日：2021-06-11
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
CPC classification number: C12N15/86 , A61K48/0041 , C12N2750/00021 , C12N2750/00043 , C12N2750/00051 , C12N2750/00071
Abstract: This invention relates generally to compositions for making anellovectors and uses thereof. For instance, a method herein can comprise providing a nucleic acid construct that comprises a first Anellovirus genome encoding an exogenous effector and a second Anellovirus genome or fragment thereof, arranged in tandem. In some embodiments, the nucleic acid construct results in production of an anellovector comprising an Anellovirus genetic element encoding the exogenous effector, enclosed in a proteinaceous exterior.
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公开(公告)号：US20230279423A1
公开(公告)日：2023-09-07
申请号：US17812896
申请日：2022-07-15
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Avak Kahvejian , Erica Gabrielle Weinstein , Nicholas McCartney Plugis , Kevin James Lebo , Fernando Martin Diaz , Dhananjay Maniklal Nawandar
IPC: C12N15/86 , C12N7/00 , C12N15/113 , C07K14/005
CPC classification number: C12N15/86 , C12N7/00 , C12N15/1136 , C07K14/005 , C12N15/113 , C12N2750/00022 , C12N2750/00043 , C12N2750/00021 , C12N2310/141 , C12N2320/32
Abstract: This invention relates generally to pharmaceutical compositions and preparations of curons and uses thereof.
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公开(公告)号：US08703468B2
公开(公告)日：2014-04-22
申请号：US13142090
申请日：2009-11-27
Applicant: Zoltan Penzes , Ferenc Misák , Tamás Tuboly , Attila Csagola
Inventor： Zoltan Penzes , Ferenc Misák , Tamás Tuboly , Attila Csagola
IPC: C12N7/00 , C07K14/005 , A61K39/00
CPC classification number: C12N7/00 , A61K2039/5254 , A61K2039/555 , C12N2750/00021 , C12N2750/10021
Abstract: The present invention relates to the novel Porcine Circovirus type 2 subtype B (PCV2B-Rm) isolate which comprises a short duplication of sequence and is adapted to grow in cell culture and may be propagated at high titres constantly up to 106 TCID50 viral particles per mL. This novel isolate is particularly useful for the production of porcine circovirus type 2 (PCV2) vaccines, for treating and/or preventing and/or diagnosing porcine circovirus associated diseases, as well as for diagnosing the presence of porcine circovirus in pigs. The present invention also relates to novel cell clones derived from Swine Testicles (ST) useful for propagating PCV2 and to a method for production of PCV2 virus with particularly high titers.
Abstract translation: 本发明涉及新型猪圆环病毒2型亚型B（PCV2B-Rm）分离物，其包含短的重复序列，并且适于在细胞培养物中生长并且可以以高滴度持续增殖至多达106TCID 50病毒颗粒/ mL 。 该新型分离物特别可用于生产猪圆环病毒2型（PCV2）疫苗，用于治疗和/或预防和/或诊断猪圆环病毒相关疾病，以及用于诊断猪圆环病毒在猪中的存在。 本发明还涉及可用于繁殖PCV2的猪睾丸（ST）的新型细胞克隆，以及特异性高滴度产生PCV2病毒的方法。
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