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公开(公告)号：US11513133B2
公开(公告)日：2022-11-29
申请号：US16194187
申请日：2018-11-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Maximilian Carpino , Ray Wheeling , Nicholas Bajka
Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
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公开(公告)号：US09778221B2
公开(公告)日：2017-10-03
申请号：US15331779
申请日：2016-10-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , John Davidson , Wolfgang Hinz , Shifeng Li , James Bustillo
IPC: G01N27/447 , B01J19/00 , G01N27/414 , C12Q1/68
CPC classification number: G01N27/4473 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00704 , B01J2219/00722 , C12Q1/6874 , G01N27/4145 , G01N27/4148 , G01N27/44743
Abstract: An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.
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公开(公告)号：US09346063B2
公开(公告)日：2016-05-24
申请号：US13828633
申请日：2013-03-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Ryan Jones , Sean McCusker , Maximilian Carpino , John Leamon , Jonathan Schultz
CPC classification number: C12Q1/6806 , B04B5/0421 , B04B13/00 , C12Q1/6869 , G01N35/00693 , G01N35/1011 , G01N2035/00495 , G01N2035/1013 , G01N2035/103
Abstract: An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm.
Abstract translation: 一种装置包括机器人系统，该机器人系统在三个正交方向上提供可操作以接收移液管尖端的臂并促进流体进入和移出移液管尖端的运动。 此外，该装置可以包括用于接收移液管吸头的托盘，用于接收管的容器，用于形成乳液的装置，用于形成包括多核苷酸的拷贝的颗粒的装置，用于富集颗粒的装置和用于加载颗粒的装置 颗粒到传感器阵列上。 该装置还可以包括容纳试剂溶液容器的容器。 可选地，除了移液管接收臂之外，机器人还可以包括夹持臂。
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公开(公告)号：US10781474B2
公开(公告)日：2020-09-22
申请号：US15133428
申请日：2016-04-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Ryan Jones , Sean McCusker , Maximilian Carpino , John Leamon , Jonathan Schultz
IPC: B04B5/04 , C12Q1/6806 , G01N35/00 , G01N35/10 , C12Q1/6869 , B04B13/00
Abstract: A sample preparation apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. In addition, the sample preparation apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles, as well as a centrifuge for loading such particles onto a sensor array. The sample preparation apparatus can further include receptacles for holding containers of reagent solutions.
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公开(公告)号：US20240255534A1
公开(公告)日：2024-08-01
申请号：US18431330
申请日：2024-02-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Ray Wheeling , Nicholas Peter Bajka , Maximilian Carpino
CPC classification number: G01N35/0098 , G01N35/0099 , G01N35/10 , G01N35/1009 , Y10T436/255
Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
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Patent Agency Ranking
公开(公告)号：US10940490B2
公开(公告)日：2021-03-09
申请号：US16207522
申请日：2018-12-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Rui Zheng , Sean McCusker
Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.
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公开(公告)号：US09267914B2
公开(公告)日：2016-02-23
申请号：US14244849
申请日：2014-04-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , John F. Davidson , Wolfgang Hinz , Shifeng Li , James Bustillo
IPC: G01N27/414 , B01J19/00
CPC classification number: G01N27/4473 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00704 , B01J2219/00722 , C12Q1/6874 , G01N27/4145 , G01N27/4148 , G01N27/44743
Abstract: An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.
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公开(公告)号：US11899029B2
公开(公告)日：2024-02-13
申请号：US17989512
申请日：2022-11-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Maximilian Carpino , Ray Wheeling , Nicholas Peter Bajka
CPC classification number: G01N35/0098 , G01N35/0099 , G01N35/10 , G01N35/1009 , Y10T436/255
Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
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公开(公告)号：US20230069977A1
公开(公告)日：2023-03-09
申请号：US17989512
申请日：2022-11-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Maximilian Carpino , Ray Wheeling , Nicholas Peter Bajka
Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
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公开(公告)号：US09535080B2
公开(公告)日：2017-01-03
申请号：US14558948
申请日：2014-12-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kristopher Barbee , Maximilian Carpino , Ray Wheeling , Nicholas Peter Bajka
CPC classification number: G01N35/0098 , G01N35/0099 , G01N35/10 , G01N35/1009 , Y10T436/255
Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
Abstract translation: 本教导提供了用于自动处理样品（例如生物或化学样品）的设备和方法。 本教导的装置和方法允许自动执行各种样品操作步骤而无需手动干预。 在优选的实施方案中，本发明提供了通过PCR产生的模板化珠的自动富集的装置和方法。
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