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    RECOMBINANT MICROORGANISM HAVING HIGH ABILITY TO PRODUCE LUTEIN AND METHOD FOR PRODUCING LUTEIN USING THE SAME
    1.
    发明申请
    RECOMBINANT MICROORGANISM HAVING HIGH ABILITY TO PRODUCE LUTEIN AND METHOD FOR PRODUCING LUTEIN USING THE SAME 有权

    公开(公告)号：US20220228177A1

    公开(公告)日：2022-07-21

    申请号：US17575460

    申请日：2022-01-13

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Sang Yup LEE ,  Seon Young PARK

    IPC: C12P7/22 ,  C12N1/20 ,  C12N15/11

    Abstract: The present invention relates to a recombinant microorganism having enhanced ability to produce lutein and a method of producing lutein using the same, and more specifically, to a recombinant microorganism having enhanced ability to produce lutein, which is obtained by modifying any one or more metabolic pathways, selected from the group consisting of a substrate tunnel, an electron tunnel, and a C5 heme production pathway, in a host cell having ability to produce lutein. Using the highly efficient lutein-producing recombinant microbial strain according to the present invention, it is possible to replace an existing lutein production method that relies on labor-intensive and inefficient plant extraction and to produce lutein in a more environmentally friendly and sustainable way. In addition, the strain development strategy used in the present invention is useful because it may be used to construct a recombinant strain for the efficient production of useful compounds with complex metabolic pathways and to establish an efficient production method, and it may be applied throughout the gradually expanding biochemical market.

    PREPARATION AND UTILIZATION OF MICROBIAL-BASED EGG FLUID SUBSTITUTE AND MILK SUBSTITUTE
    7.
    发明申请
    PREPARATION AND UTILIZATION OF MICROBIAL-BASED EGG FLUID SUBSTITUTE AND MILK SUBSTITUTE 有权

    公开(公告)号：US20240381913A1

    公开(公告)日：2024-11-21

    申请号：US18661648

    申请日：2024-05-12

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Sang Yup LEE ,  Kyeong Rok CHOI ,  Da-Hee AHN ,  Seok Yeong JUNG

    IPC: A23L15/00 ,  A23C11/06 ,  C12N1/06

    Abstract: A method of preparing a food composition for an egg fluid substitute or for a milk substitute is described, including a step of lysing microorganisms, and corresponding food compositions prepared by such method. The egg fluid substitute or milk substitute changes into a gel having properties similar to egg fluid when heated and exhibits excellent foaming performance, and can replace egg fluid in a wide range of food applications, including confectionery and baking. The described method enables the production of an egg fluid substitute or milk substitute in an environmentally friendly and sustainable manner, and provides a method for utilizing nutritionally valuable microorganisms as an egg fluid substitute or a milk substitute, as well as contributing to the food industry by expanding the choice of food ingredients.

    SRNA PLATFORM FOR INHIBITING PROKARYOTIC EXPRESSION AND USE THEREOF
    8.
    发明公开
    SRNA PLATFORM FOR INHIBITING PROKARYOTIC EXPRESSION AND USE THEREOF 审中-公开

    公开(公告)号：US20240018520A1

    公开(公告)日：2024-01-18

    申请号：US18340838

    申请日：2023-06-24

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Sang Yup LEE ,  Dongsoo YANG ,  Jae Sung CHO

    IPC: C12N15/113 ,  C12N15/63

    CPC classification number: C12N15/113 ,  C12N2310/10 ,  C12N15/63

    Abstract: Synthetic sRNA for inhibiting prokaryote gene expression is described, which includes (i) an Hfq binding site and (ii) a region that forms a complementary bond with a target gene mRNA. Vectors encoding the synthetic sRNA are described, as well as recombinant prokaryotes transformed with such vectors, methods of inhibiting prokaryote gene expression, and methods of gene screening and strain improvement. The synthetic sRNA is able to control single and multiple target genes at a time, and is particularly useful for inhibiting a gene expression of Gram-positive bacteria, e.g., in a recombinant Corynebacterium for mass production of high value products that do not require fossil fuels with associated environmental problems.

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