公开(公告)号：US20220017879A1

公开(公告)日：2022-01-20

申请号：US17366269

申请日：2021-07-02

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yup LEE ,  Junho BANG ,  Chang Hun HWANG ,  Jung Ho AHN ,  Jong An LEE

IPC: C12N9/10 ,  C12N9/04 ,  C12N9/00 ,  C12N9/78 ,  C12P7/16 ,  C12P7/04 ,  C12P13/10 ,  C12P5/00 ,  C12P5/02 ,  C12P13/00 ,  C12P7/42 ,  C12P17/10 ,  C12P7/46 ,  C12P13/06 ,  C12P13/08 ,  C12P7/02

Abstract: Disclosed is a recombinant microorganism capable of growing using only carbon dioxide and formic acid by introducing and improving a metabolic pathway for synthesizing pyruvic acid from carbon dioxide and formic acid to enhance pyruvic acid synthesis efficiency and performing additional genetic manipulation, and a method for producing useful substances using the same. Advantageously, the recombinant microorganism is capable of synthesizing pyruvic acid, a C3 organic compound, at a remarkably improved rate, and in particular, grows well even in a medium containing only carbon dioxide and formic acid as carbon sources without a glucose supply, and is thereby capable of synthesizing pyruvic acid and various high value-added compounds using the same as an intermediate product in an economically efficient manner.

公开(公告)号：US20190338316A1

公开(公告)日：2019-11-07

申请号：US16472876

申请日：2017-11-20

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yup LEE ,  Junho BANG

IPC: C12P1/04 ,  C12N15/70 ,  C12P13/04 ,  C12P5/02 ,  C12P7/04 ,  C12P7/24

Abstract: The present invention relates to a recombinant microorganism having heterologous genes introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention provides a novel microorganism having a cyclic metabolic pathway introduced thereto through which C3 or higher carbon organic compounds can be synthesized from formic acid and carbon dioxide, whereby carbon dioxide rich in nature and formic acid that is of low toxicity and suitable for anabolic reaction in view of reaction kinetics and which can be easily and rapidly synthesized from carbon dioxide can be used to effectively synthesize the C3 organic compound pyruvic acid from which various high-value added compound can be synthesized.