公开(公告)号：US20230296620A1

公开(公告)日：2023-09-21

申请号：US17965406

申请日：2022-10-13

Applicant: Genentech, Inc.

Inventor： Keyang Xu ,  Jintang He ,  Surinder Kaur

IPC: G01N33/68 ,  G01N30/72 ,  G01N30/20 ,  G01N30/32 ,  G01N30/88 ,  G01N30/46 ,  B01D15/32 ,  B01D15/18

CPC classification number: G01N33/6848 ,  G01N30/7233 ,  G01N30/20 ,  G01N30/32 ,  G01N30/88 ,  G01N30/463 ,  B01D15/325 ,  B01D15/1878 ,  G01N2333/976 ,  G01N2030/027

Abstract: The present application relates to systems and methods for assaying presence of large molecule analytes, such as proteins, e.g., antibodies, antigens, receptors, and the like, using a targeted two-dimensional liquid chromatography, tandem mass spectrometry (2D-LC-MS/MS) system, optionally combined with affinity capture. In some aspects, the system is partially or fully automated. In some aspects, the system may allow detection of protein biomarkers (e.g., antibodies or antigens) from clinical or nonclinical biological tissue or fluid samples in the pg/mL to ng/mL range.

公开(公告)号：US20210011000A1

公开(公告)日：2021-01-14

申请号：US16883152

申请日：2020-05-26

Applicant: Genentech, Inc.

Inventor： Martine Darwish ,  Surinder Kaur ,  Dian Su ,  Keyang Xu

IPC: G01N33/50 ,  G01N33/68 ,  C12Q1/37 ,  A61K38/02 ,  A61K39/395 ,  G01N33/53

Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.

公开(公告)号：US20240110909A1

公开(公告)日：2024-04-04

申请号：US18514615

申请日：2023-11-20

Applicant: Genentech, Inc.

Inventor： Martine Darwish ,  Surinder Kaur ,  Dian Su ,  Keyang Xu

IPC: G01N33/50 ,  A61K38/02 ,  A61K39/395 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/68

CPC classification number: G01N33/5005 ,  A61K38/02 ,  A61K39/395 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/6848 ,  G01N33/6857 ,  C07K14/00

Abstract: Methods are provided to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.

公开(公告)号：US11860156B2

公开(公告)日：2024-01-02

申请号：US16883152

申请日：2020-05-26

Applicant: Genentech, Inc.

Inventor： Martine Darwish ,  Surinder Kaur ,  Dian Su ,  Keyang Xu

IPC: G01N33/50 ,  G01N33/68 ,  C12Q1/37 ,  A61K38/02 ,  A61K39/395 ,  G01N33/53 ,  C07K14/00

CPC classification number: G01N33/5005 ,  A61K38/02 ,  A61K39/395 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/6848 ,  G01N33/6857 ,  C07K14/00

Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.

公开(公告)号：US20170370906A1

公开(公告)日：2017-12-28

申请号：US15606304

申请日：2017-05-26

Applicant: Genentech, Inc.

Inventor： Martine Darwish ,  Surinder Kaur ,  Dian Su ,  Keyang Xu

IPC: G01N33/50 ,  A61K39/395 ,  G01N33/53 ,  A61K38/02 ,  C07K14/00

CPC classification number: G01N33/5005 ,  A61K38/02 ,  A61K39/395 ,  C07K14/00 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/6848 ,  G01N33/6857

Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.

公开(公告)号：US20160002355A1

公开(公告)日：2016-01-07

申请号：US14860344

申请日：2015-09-21

Applicant: Genentech, Inc.

Inventor： Jo-Anne Hongo ,  Yanhong Li ,  Luna Liu ,  John Lowe ,  Mauricio Maia ,  Rajesh Vij ,  Terence Wong ,  Keyang Xu

IPC: C07K16/42 ,  G01N33/68

CPC classification number: C07K16/4216 ,  C07K16/088 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/56994 ,  G01N33/686 ,  G01N2333/045 ,  G01N2469/20

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.