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公开(公告)号：US20240158741A1
公开(公告)日：2024-05-16
申请号：US18421847
申请日：2024-01-24
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N2501/115 , C12N2501/125 , C12N2501/15 , C12N2501/26
摘要： This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production capacity of the culture environment. The new culture system of this invention allows for bulk proliferation of hES cells in a more cost-effective manner, which facilitates commercial production of important products for use in human therapy.
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公开(公告)号：US10676714B2
公开(公告)日：2020-06-09
申请号：US15894842
申请日：2018-02-12
IPC分类号： C12N5/0735
摘要： This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production capacity of the culture environment. The new culture system of this invention allows for bulk proliferation of hES cells in a more cost-effective manner, which facilitates commercial production of important products for use in human therapy.
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公开(公告)号：US20140106343A1
公开(公告)日：2014-04-17
申请号：US14010578
申请日：2013-08-27
发明人： Ramkumar Mandalam , Saadia Faouzi , Isabelle Nadeau , Kristina Pfendler-Bonham , Namitha Rao , Melissa K. Carpenter , Lakshmi Rambhatla , Choy-Pik Chiu
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/148 , C12N2501/155 , C12N2501/23 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/39 , C12N2502/13 , C12N2503/02 , C12N2506/02 , C12N2533/90 , C12N2533/92
摘要： This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ layer cells, then into hepatocyte precursors, and then into mature cells. The cells obtained have morphological features and phenotypic markers characteristic of human adult hepatocytes. They also show evidence of cytochrome p450 enzyme activity, validating their utility for commercial applications such as drug screening, or use in the manufacture of medicaments and medical devices for clinical therapy.
摘要翻译： 本公开提供了一种新开发的策略和将多能干细胞分化成肝细胞谱系细胞的特定选择。 许多方案都是基于这样的策略，其中细胞首先分化成早期胚层细胞，然后分化成肝细胞前体，然后进入成熟细胞。 获得的细胞具有形态学特征和人成人肝细胞特征的表型标志物。 它们还显示细胞色素p450酶活性的证据，验证其在商业应用中的用途，例如药物筛选，或用于制备用于临床治疗的药物和医疗装置。
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公开(公告)号：US20190017014A1
公开(公告)日：2019-01-17
申请号：US15894842
申请日：2018-02-12
IPC分类号： C12N5/0735
摘要： This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production capacity of the culture environment. The new culture system of this invention allows for bulk proliferation of hES cells in a more cost-effective manner, which facilitates commercial production of important products for use in human therapy.
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公开(公告)号：US09587223B2
公开(公告)日：2017-03-07
申请号：US14010578
申请日：2013-08-27
发明人： Ramkumar Mandalam , Saadia Faouzi , Isabelle Nadeau , Kristina Pfendler-Bonham , Namitha Rao , Melissa K. Carpenter , Lakshmi Rambhatla , Choy-Pik Chiu
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/148 , C12N2501/155 , C12N2501/23 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/39 , C12N2502/13 , C12N2503/02 , C12N2506/02 , C12N2533/90 , C12N2533/92
摘要： This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ layer cells, then into hepatocyte precursors, and then into mature cells. The cells obtained have morphological features and phenotypic markers characteristic of human adult hepatocytes. They also show evidence of cytochrome p450 enzyme activity, validating their utility for commercial applications such as drug screening, or use in the manufacture of medicaments and medical devices for clinical therapy.
摘要翻译： 本公开提供了一种新开发的策略和将多能干细胞分化成肝细胞谱系细胞的特定选择。 许多方案都是基于这样的策略，其中细胞首先分化成早期胚层细胞，然后分化成肝细胞前体，然后进入成熟细胞。 获得的细胞具有形态学特征和人成人肝细胞特征的表型标志物。 它们还显示细胞色素p450酶活性的证据，验证其在商业应用中的用途，例如药物筛选，或用于制备用于临床治疗的药物和医疗装置。
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公开(公告)号：US20150307838A1
公开(公告)日：2015-10-29
申请号：US14791479
申请日：2015-07-06
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N2501/115 , C12N2501/125 , C12N2501/15 , C12N2501/26
摘要： This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production capacity of the culture environment. The new culture system of this invention allows for bulk proliferation of hES cells in a more cost-effective manner, which facilitates commercial production of important products for use in human therapy.
摘要翻译： 本公开提供了用于培养人胚胎干细胞的改进的系统。 将细胞悬浮培养，以使培养环境的生产能力最大化。 本发明的新培养系统允许以更具成本效益的方式大量增殖hES细胞，这促进了用于人类治疗的重要产物的商业生产。
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