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公开(公告)号：US07344892B2
公开(公告)日：2008-03-18
申请号：US10947791
申请日：2004-09-23
IPC分类号： G01N33/53 , G01N33/577
CPC分类号： G01N33/689 , G01N33/6893 , G01N2800/042 , G01N2800/321 , G01N2800/36 , G01N2800/368 , G01N2800/52 , G06F19/00 , Y10S436/804 , Y10S436/809
摘要： The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.
摘要翻译： 本发明涉及用于识别具有或倾向于具有妊娠糖尿病，先兆子痫和妊娠高血压的受试者的方法和组合物。 该方法适用于尿液和/或血液样品，可在妊娠前三个月进行。
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公开(公告)号：US20140378507A1
公开(公告)日：2014-12-25
申请号：US14232196
申请日：2012-07-11
申请人： Peter Kang , Ananth Karumanchi , Santosh Khedkar , Alan Rigby , Ravi I. Thadhani
发明人： Peter Kang , Ananth Karumanchi , Santosh Khedkar , Alan Rigby , Ravi I. Thadhani
IPC分类号： C07D215/54 , C07C311/21
CPC分类号： C07D215/54 , A61K31/47 , A61K31/63 , C07C311/21 , C07C311/46
摘要： This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders, proliferative disease, renal disease, and thrombosis.
摘要翻译： 本发明的特征在于维生素D受体激动剂及其在治疗骨病，心血管疾病，甲状旁腺功能亢进，免疫疾病，增殖性疾病，肾脏疾病和血栓形成中的用途。
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公开(公告)号：US20140228296A1
公开(公告)日：2014-08-14
申请号：US14131866
申请日：2012-07-13
IPC分类号： A61K38/06 , A61K31/4172 , A61K31/255 , A61K31/145 , A61K38/05 , A61K31/198
CPC分类号： A61K38/063 , A61K31/145 , A61K31/198 , A61K31/255 , A61K31/4172 , A61K38/05 , A61K38/06 , A61K45/06 , C07K16/205 , C07K2317/33 , C07K2317/34 , G01N33/6806 , G01N33/6893 , G01N2333/765 , G01N2440/00 , G01N2800/347 , G06F19/00 , Y02A90/26 , A61K2300/00
摘要： The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.
摘要翻译： 本发明涉及在患有肾脏疾病（例如终末期肾病）的患者中白蛋白的增加部分被氨基甲酰化，并且氨基甲酰化白蛋白的部分也与增加的疾病严重性，特别是死亡风险相关的发现。 本发明还涉及游离氨基酸可以减少白蛋白氨基甲酰化的发现。 基于这些发现，本发明为患有或怀疑患有肾脏疾病的患者提供诊断和预后方法。 本发明还提供了通过施用减少蛋白质氨基甲酰化的化合物或组合物（例如游离氨基酸或二肽）来治疗肾脏疾病的方法。
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公开(公告)号：US09549964B2
公开(公告)日：2017-01-24
申请号：US14131866
申请日：2012-07-13
IPC分类号： A61K31/198 , A61K38/06 , A61K38/05 , A61K45/06 , G01N33/68 , C07K16/20 , A61K31/145 , A61K31/255 , A61K31/4172
CPC分类号： A61K38/063 , A61K31/145 , A61K31/198 , A61K31/255 , A61K31/4172 , A61K38/05 , A61K38/06 , A61K45/06 , C07K16/205 , C07K2317/33 , C07K2317/34 , G01N33/6806 , G01N33/6893 , G01N2333/765 , G01N2440/00 , G01N2800/347 , G06F19/00 , Y02A90/26 , A61K2300/00
摘要： The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.
摘要翻译： 本发明涉及在患有肾脏疾病（例如终末期肾病）的患者中白蛋白的增加部分被氨基甲酰化，并且氨基甲酰化白蛋白的部分也与增加的疾病严重性，特别是死亡风险相关的发现。 本发明还涉及游离氨基酸可以减少白蛋白氨基甲酰化的发现。 基于这些发现，本发明为患有或怀疑患有肾脏疾病的患者提供诊断和预后方法。 本发明还提供了通过施用减少蛋白质氨基甲酰化的化合物或组合物（例如游离氨基酸或二肽）来治疗肾脏疾病的方法。
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公开(公告)号：US09499488B2
公开(公告)日：2016-11-22
申请号：US14232196
申请日：2012-07-11
IPC分类号： A01N43/42 , A61K31/47 , C07D215/54 , A61K31/63 , C07C311/46 , C07C311/21
CPC分类号： C07D215/54 , A61K31/47 , A61K31/63 , C07C311/21 , C07C311/46
摘要： This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders, proliferative disease, renal disease, and thrombosis.
摘要翻译： 本发明的特征在于维生素D受体激动剂及其在治疗骨病，心血管疾病，甲状旁腺功能亢进，免疫疾病，增殖性疾病，肾脏疾病和血栓形成中的用途。
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公开(公告)号：US20080213794A1
公开(公告)日：2008-09-04
申请号：US11971598
申请日：2008-01-09
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , G01N33/6893 , G01N2800/042 , G01N2800/321 , G01N2800/36 , G01N2800/368 , G01N2800/52 , Y10S436/804 , Y10S436/809
摘要： The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.
摘要翻译： 本发明涉及用于识别具有或倾向于具有妊娠糖尿病，先兆子痫和妊娠高血压的受试者的方法和组合物。 该方法适用于尿液和/或血液样品，可在妊娠前三个月进行。
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公开(公告)号：US07323346B2
公开(公告)日：2008-01-29
申请号：US10920116
申请日：2004-08-16
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/689 , G01N2333/505 , G01N2333/52 , G01N2333/525 , G01N2333/53 , G01N2333/54 , G01N2333/555 , G01N2333/5756 , G01N2333/61 , G01N2800/368 , G06F19/20 , Y10S436/811
摘要： The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy, and as early as the first trimester.
摘要翻译： 本发明涉及用于鉴定具有妊娠糖尿病，先兆子痫和妊娠高血压患有或倾向于具有妊娠糖尿病，先兆子痫和妊娠高血压的怀孕受试者的方法和组合 这些方法适用于尿液和/或血液样品，可以在妊娠前三个月，早在妊娠前期进行。
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