公开(公告)号：US20120122837A1

公开(公告)日：2012-05-17

申请号：US13242426

申请日：2011-09-23

Applicant: CLIFFORD CHENG ,  GERALD W. SHIPPS, JR. ,  XIAOHUA HUANG ,  YING HUANG ,  NING SHAO ,  ASHWIN RAO ,  ANANDAN PALANI ,  PETER ORTH ,  JOHANNES H. VOIGT ,  ROBERT J. HERR ,  LANA MICHELE ROSSITER ,  QI ZENG ,  XIANFENG SUN

Inventor： CLIFFORD CHENG ,  GERALD W. SHIPPS, JR. ,  XIAOHUA HUANG ,  YING HUANG ,  NING SHAO ,  ASHWIN RAO ,  ANANDAN PALANI ,  PETER ORTH ,  JOHANNES H. VOIGT ,  ROBERT J. HERR ,  LANA MICHELE ROSSITER ,  QI ZENG ,  XIANFENG SUN

IPC: A61K31/498 ,  A61K31/5377 ,  A61K31/4709 ,  C07D413/06 ,  A61K31/506 ,  C07D471/04 ,  C07D403/06 ,  C07D401/14 ,  A61K31/4985 ,  C07D403/14 ,  C07D241/44 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P3/06 ,  A61K31/55

CPC classification number: C07D403/06 ,  C07D241/44 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/06

Abstract: The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

Abstract translation: 本发明涉及作为脂肪酸结合蛋白（“FABP”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物和用于治疗或预防心血管疾病，代谢障碍，肥胖或肥胖相关的化合物的用途 糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量减低或空腹血糖受损。

公开(公告)号：US08420863B2

公开(公告)日：2013-04-16

申请号：US13360285

申请日：2012-01-27

Applicant: Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

IPC: C07C211/03 ,  A61K31/135

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了苯乙烯衍生物化合物，包括但不限于二苯乙烯衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20090170841A1

公开(公告)日：2009-07-02

申请号：US12107040

申请日：2008-04-21

Applicant: Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

IPC: A61K31/5375 ,  C07C211/02 ,  A61K31/135 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/164 ,  A61P25/00 ,  C07C233/01 ,  C07C237/02 ,  C07D241/04 ,  C07D211/06 ,  C07D207/04 ,  C07D295/00

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了苯乙烯衍生物化合物，包括但不限于二苯乙烯衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20120129860A1

公开(公告)日：2012-05-24

申请号：US13360285

申请日：2012-01-27

Applicant: Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

IPC: A61K31/5375 ,  C07D295/03 ,  C07C323/32 ,  C07C317/32 ,  C07C237/20 ,  A61K31/137 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/145 ,  A61K31/167 ,  C12N5/079 ,  A61P27/02 ,  A61P27/10 ,  C07C211/27

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了苯乙烯衍生物化合物，包括但不限于二苯乙烯衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US08889683B2

公开(公告)日：2014-11-18

申请号：US13242426

申请日：2011-09-23

Applicant: Clifford Cheng ,  Gerald W. Shipps, Jr. ,  Xiaohua Huang ,  Ying Huang ,  Ning Shao ,  Ashwin Rao ,  Anandan Palani ,  Peter Orth ,  Johannes H. Voigt ,  Robert J. Herr ,  Lana Michele Rossiter ,  Qi Zeng ,  Xianfeng Sun

Inventor： Clifford Cheng ,  Gerald W. Shipps, Jr. ,  Xiaohua Huang ,  Ying Huang ,  Ning Shao ,  Ashwin Rao ,  Anandan Palani ,  Peter Orth ,  Johannes H. Voigt ,  Robert J. Herr ,  Lana Michele Rossiter ,  Qi Zeng ,  Xianfeng Sun

IPC: A61K31/498 ,  C07D241/44 ,  C07D401/14 ,  C07D403/14 ,  C07D413/06 ,  C07D401/06 ,  C07D403/12 ,  C07D403/06

CPC classification number: C07D403/06 ,  C07D241/44 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/06

Abstract: The present invention relates to novel quinoxaline compounds of Formula I: as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the quinoxaline compounds and the use of the quinoxaline compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

Abstract translation: 本发明涉及式I的新型喹喔啉化合物：作为脂肪酸结合蛋白（“FABP”）抑制剂，包含喹喔啉化合物的药物组合物和喹喔啉化合物用于治疗或预防心血管疾病，代谢紊乱，肥胖症 或肥胖相关疾病，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。

公开(公告)号：US20130253064A1

公开(公告)日：2013-09-26

申请号：US13789259

申请日：2013-03-07

Applicant: Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

IPC: C07C211/27 ,  C07C225/06 ,  C07C217/62 ,  C07C215/08 ,  C07C217/10

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.