公开(公告)号：US09162161B2

公开(公告)日：2015-10-20

申请号：US13638751

申请日：2011-03-29

申请人： Kouji Tamori ,  Takayoshi Abe ,  Yusuke Okano ,  Masaki Momiyama ,  Hiroshi Kawai ,  Satoshi Hyugaji ,  Tomonori Shiotani ,  Kazuhiro Ikkyu ,  Yong Wang

发明人： Kouji Tamori ,  Takayoshi Abe ,  Yusuke Okano ,  Masaki Momiyama ,  Hiroshi Kawai ,  Satoshi Hyugaji ,  Tomonori Shiotani ,  Kazuhiro Ikkyu ,  Yong Wang

IPC分类号： B01D15/04 ,  B01D15/08 ,  B01D15/38 ,  C08F8/00 ,  C08F220/26 ,  B01J20/26 ,  B01J20/286

CPC分类号： B01D15/3804 ,  B01J20/265 ,  B01J20/286 ,  C08F8/00 ,  C08F220/26 ,  Y10T428/2982

摘要： Provided is a filler for affinity chromatography having a high dynamic binding capacity for proteins and having excellent alkali resistance and storage stability. The filler for affinity chromatography of the present invention comprises a porous particle consisting of a copolymer of 40 parts to 99.5 parts by mass of (M-1) a methacryloyl group-containing vinyl monomer that contains a hydroxyl group and does not contain an epoxy group, 0.5 parts to 30 parts by mass of (M-2) an epoxy group-containing vinyl monomer, 0 parts to 59.5 parts by mass of (M-3) a methacryloyl group-containing vinyl monomer which is other than the monomers (M-1) and (M-2), and 0 parts to 25 parts by mass of (M-4) a vinyl monomer other than the monomers (M-1), (M-2) and (M-3) (with the proviso that the total amount of the contents of (M-1), (M-2), (M-3) and (M-4) is 100 parts by mass); ring-opened epoxy group obtainable by ring-opening of epoxy group that is contained in the copolymer; and ligand that is bound to the porous particle.

摘要翻译： 本发明提供一种对蛋白质具有高动态结合能力并具有优异的耐碱性和储存稳定性的亲和层析用填料。 本发明的亲和层析用填料包含由40〜99.5质量份的含有甲基丙烯酰基的含有甲基丙烯酰基的乙烯基单体（不含有环氧基）的（M-1）共聚物构成的多孔质粒子 ，（M-2）含有环氧基的乙烯基单体0.5〜30质量份，除了单体（M）以外的（M-3）含有甲基丙烯酰基的乙烯基单体的（M-3） -1）和（M-2）和0〜25质量份（M-4）除了单体（M-1），（M-2）和（M-3） 条件是（M-1），（M-2），（M-3）和（M-4）的含量的总量为100质量份） 通过共聚物中包含的环氧基开环获得的开环环氧基; 和与多孔颗粒结合的配体。

公开(公告)号：US09090665B2

公开(公告)日：2015-07-28

申请号：US13638826

申请日：2011-03-29

申请人： Kouji Tamori ,  Takayoshi Abe ,  Yusuke Okano ,  Masaki Momiyama ,  Hiroshi Kawai ,  Satoshi Hyugaji ,  Yong Wang

发明人： Kouji Tamori ,  Takayoshi Abe ,  Yusuke Okano ,  Masaki Momiyama ,  Hiroshi Kawai ,  Satoshi Hyugaji ,  Yong Wang

IPC分类号： G01N33/547 ,  C07K1/14 ,  G01N33/545 ,  C07K1/18 ,  B01D15/38 ,  C08F222/10 ,  B01J20/286 ,  C07K1/22

CPC分类号： C07K1/18 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/286 ,  C07K1/22 ,  C08F222/1006 ,  C08F220/20 ,  C08F2220/325 ,  C08F2220/281 ,  C08F220/58

摘要： Provided is a filler for affinity chromatography which is useful for protein purification and contains porous particles that have a high dynamic binding capacity for proteins and excellent pressure characteristics. The filler for affinity chromatography of the present invention is characterized in that it includes a porous particle consisting of a polymer of vinyl monomer including a cross-linkable vinyl monomer that contains hydroxyl group but does not contain epoxy group and an epoxy group-containing non-cross-linkable vinyl monomer, or a cross-linkable vinyl monomer that contains hydroxyl group and epoxy group, ligands bound to the porous particle, and ring-opened epoxy groups.

摘要翻译： 提供了用于亲和层析的填充剂，其用于蛋白质纯化，并且包含对于蛋白质具有高动态结合能力和优异的压力特性的多孔颗粒。 本发明的亲和层析用填料的特征在于，它包括由包含含有羟基但不含环氧基的可交联乙烯基单体的乙烯基单体的聚合物组成的多孔颗粒， 或可交联乙烯基单体，或含有羟基和环氧基的可交联乙烯基单体，与多孔颗粒结合的配体和开环的环氧基。

公开(公告)号：US08859699B2

公开(公告)日：2014-10-14

申请号：US12602138

申请日：2008-05-19

申请人： Kouji Tamori ,  Eiji Takamoto ,  Toshihiro Ogawa

发明人： Kouji Tamori ,  Eiji Takamoto ,  Toshihiro Ogawa

IPC分类号： C08F222/36 ,  C08F20/58 ,  C08F26/10 ,  C08F220/52

CPC分类号： C08F220/52

摘要： A non-specific adsorption inhibitor includes a water-soluble polymer obtained by polymerizing a monomer unit that includes a monomer (A) that forms a polymer that has a lower critical solution temperature (LCST) of 80° C. or less in an aqueous solution under normal pressure when subjected to homopolymerization, and a monomer (B) that forms a polymer that does not have the LCST in an aqueous solution under normal pressure when subjected to homopolymerization.

摘要翻译： 非特异性吸附抑制剂包括通过聚合单体单元获得的水溶性聚合物，该单体单元包括在水溶液中形成具有低于80℃或更低的临界溶解温度（LCST）的聚合物的单体（A） 在正常压力下进行均聚反应的单体（B）和在常压下在水溶液中形成不具有LCST的聚合物的单体（B）进行均聚。

公开(公告)号：US08617803B2

公开(公告)日：2013-12-31

申请号：US11954289

申请日：2007-12-12

申请人： Kouji Tamori ,  Eiji Takamoto

发明人： Kouji Tamori ,  Eiji Takamoto

IPC分类号： G01N30/00 ,  G01N33/53 ,  G01N33/531 ,  G01N33/532

CPC分类号： G01N33/54326 ,  G01N33/531 ,  G01N33/54353

摘要： A method for producing a non-specific adsorption inhibitor includes reacting (A) a tosylated compound of polyoxyethylene monomethyl ether with (B) a polyamine having either an amino group or imino group (—NH—), or both, in total of 3 to 12.

摘要翻译： 非特异性吸附抑制剂的制造方法包括使（A）聚氧乙烯一甲醚的甲苯磺酰化化合物与（B）具有氨基或亚氨基（-NH-）的多胺或二者的总量为3〜 12。

公开(公告)号：US07732051B2

公开(公告)日：2010-06-08

申请号：US11772616

申请日：2007-07-02

申请人： Kouji Tamori ,  Eiji Takamoto ,  Masaru Ueno ,  Tetsuo Fukuta ,  Tomohiro Uetsuhara ,  Mitsuhiro Murata

发明人： Kouji Tamori ,  Eiji Takamoto ,  Masaru Ueno ,  Tetsuo Fukuta ,  Tomohiro Uetsuhara ,  Mitsuhiro Murata

IPC分类号： B32B5/16

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/86 ,  Y10S525/902 ,  Y10T428/2998

摘要： A method for producing magnetic particles includes forming a hydrophobic first polymer layer on the surface of a mother particle containing superparamagnetic particles, forming a second polymer layer having glycidyl groups at least on its surface on the first polymer layer, and introducing a polar group containing one or more of at least one atom selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom by chemically modifying the glycidyl groups.

摘要翻译： 制造磁性粒子的方法包括在含有超顺磁性粒子的母粒子的表面形成疏水性第一聚合物层，在第一聚合物层上至少在其表面上形成具有缩水甘油基的第二聚合物层，并引入含有一个 或更多的选自氧原子，氮原子和硫原子的至少一个原子，通过化学改性缩水甘油基。

公开(公告)号：US07713627B2

公开(公告)日：2010-05-11

申请号：US11688653

申请日：2007-03-20

申请人： Kouji Tamori ,  Tetsuo Fukuta ,  Satoshi Katayose ,  Masaru Ueno ,  Mitsuhiro Murata

发明人： Kouji Tamori ,  Tetsuo Fukuta ,  Satoshi Katayose ,  Masaru Ueno ,  Mitsuhiro Murata

IPC分类号： B32B5/16

CPC分类号： G01N33/5434 ,  G01N33/54393 ,  Y10S525/921 ,  Y10T428/2991 ,  Y10T428/2998

摘要： Magnetic particles comprising a group shown by the following formula (1): wherein R1 and R2 individually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that R1 and R2 are not both hydrogen atoms, wherein R3 represents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and wherein R4 is a hydrogen atom or an alkyl group.

摘要翻译： 包含由下式（1）表示的基团的磁性颗粒：其中R1和R2各自表示羟基，下式（2）表示的基团或下式（3）所示的基团，条件是R1 并且R 2不是氢原子，其中R 3表示具有2至6个碳原子的直链，支链或环状亚烷基或亚芳基，并且其中R4是氢原子或烷基。

公开(公告)号：US20080312394A1

公开(公告)日：2008-12-18

申请号：US12135518

申请日：2008-06-09

申请人： Kouji TAMORI ,  Eiji Takamoto ,  Toshihiro Ogawa

发明人： Kouji TAMORI ,  Eiji Takamoto ,  Toshihiro Ogawa

IPC分类号： C08F120/00

CPC分类号： C08F220/56 ,  C08F220/14 ,  C08F220/26

摘要： A protein stabilizing agent comprising a copolymer comprising: a repeating unit (A) represented by the following formula (1) and a repeating unit (B) represented by the following formula (2): wherein R1, R2, R3 and R4 are defined in the description.

摘要翻译： 一种蛋白质稳定剂，其包含共聚物，其包含：由下式（1）表示的重复单元（A）和由下式（2）表示的重复单元（B）：其中R1，R2，R3和R4定义于 说明。

公开(公告)号：US20080227893A1

公开(公告)日：2008-09-18

申请号：US10587220

申请日：2005-01-25

申请人： Kouji Tamori ,  Yasuhisa Watanabe ,  Akira Nishikawa

发明人： Kouji Tamori ,  Yasuhisa Watanabe ,  Akira Nishikawa

IPC分类号： C08L95/00 ,  C08J3/05

CPC分类号： G02B5/0242 ,  C08F265/02 ,  C08F265/04 ,  C08J3/11 ,  G02B5/0247 ,  G02B5/0278

摘要： A hollow particles-containing liquid composition which comprises:(A) crosslinked hollow particles having particle diameters of 0.4 μm or more and containing 40 mass % or more of a toluene insoluble, in an amount of 5 to 70 mass %,(B) a reactive diluent (B1) and/or an organic solvent (B2) in an amount of 95 to 30 mass % [the total mass of the crosslinked hollow particles (A) and the reactive diluent (B1) and/or the organic solvent (B2) is 100 mass %], and(C) a dispersing agent in an amount of 0 to 30 parts by mass relative to 100 parts by mass of the total of the crosslinked hollow particles (A) and the reactive diluent (B1) and/or the organic solvent (B2). There are provided a hollow particles-containing liquid composition which is low in foreign matter content and can give a high haze, a process for production thereof, and an optical article.

摘要翻译： 含有中空颗粒的液体组合物，其包含：（A）5〜70质量％的粒径为0.4μm以上且含有40质量％以上甲苯不溶性的交联中空粒子，（B）a 反应性稀释剂（B1）和/或有机溶剂（B2）的含量为95〜30质量％[交联中空粒子（A）和反应性稀释剂（B1）和/或有机溶剂（B2 ）为100质量％]，（C）相对于交联中空粒子（A）和反应性稀释剂（B1）的总量100质量份，0〜30质量份的分散剂和/ 或有机溶剂（B2）。 提供了含有异物含量低，可能产生高雾度的中空颗粒的液体组合物，其制造方法和光学制品。

公开(公告)号：US20050113505A1

公开(公告)日：2005-05-26

申请号：US10992816

申请日：2004-11-22

申请人： Yasuhisa Watanabe ,  Kouji Tamori

发明人： Yasuhisa Watanabe ,  Kouji Tamori

IPC分类号： C08F2/38 ,  C08F257/02 ,  C08F291/00 ,  C08J9/20 ,  C09D11/00 ,  C09D11/18 ,  C09D11/322 ,  C09D11/324 ,  C09D11/326 ,  C09D11/328 ,  C09D11/38 ,  G03G5/00

CPC分类号： C09D11/18 ,  C08F257/02 ,  C09D11/16 ,  C09D11/30 ,  C08F220/10

摘要： Disclosed are hollow polymer particles composed of a crosslinked polymer having a comparatively small particle diameter and a narrow particle diameter distribution, an aqueous dispersion of the particles, and an ink having good flying property. The hollow polymer particles are obtained by emulsion-polymerizing a crosslinkable polymerizable monomer composition absorbed in seed particles and containing a crosslinkable monomer component and a hydrophilic monomer component, wherein the seed particles are particles of a polymer having a weight average molecular weight of 500 to 15,000, and obtained by emulsion-polymerizing 100 parts by mass of a non-crosslinkable polymerizable monomer in the presence of 0.01 to 5 parts by mass of a chain transfer agent composed of at least one compound selected from the group consisting of α-methylstyrene dimer, thiuram disulfides and terpene hydrocarbons. The ink contains the hollow polymer particles.

摘要翻译： 公开了由具有较小粒径和窄粒径分布的交联聚合物，颗粒的水分散体和具有良好飞行性能的油墨组成的中空聚合物颗粒。 中空聚合物颗粒通过将吸附在种子颗粒中并含有可交联单体组分和亲水单体组分的可交联聚合单体组合物进行乳液聚合而获得，其中种子颗粒是重均分子量为500至15,000的聚合物颗粒 通过在0.01〜5质量份的由至少一种选自由α-甲基苯乙烯二聚体，甲基苯乙烯二聚物，甲基苯乙烯二聚物组成的组中选择的化合物的链转移剂的存在下，将100质量份的不可交联聚合性单体进行乳液聚合， 秋兰姆二硫化物和萜烯烃。 油墨含有中空聚合物颗粒。

公开(公告)号：US06624272B2

公开(公告)日：2003-09-23

申请号：US09739257

申请日：2000-12-19

申请人： Satoshi Futami ,  Kouji Tamori ,  Katsuhiko Tsuruoka

发明人： Satoshi Futami ,  Kouji Tamori ,  Katsuhiko Tsuruoka

IPC分类号： C08F23612

CPC分类号： D21H19/42 ,  C08F257/02 ,  C08F265/04 ,  C08F265/08 ,  C08F271/00 ,  C08L51/003 ,  C09D151/003 ,  D21H21/54 ,  C08L2666/02

摘要： An object of the present invention is to provide cationic hollow crosslinked polymer particles that maintain a cationic property over a wide pH range, has adequate strength, and is favorable for use in filled paper, pigments for coating paper, additives for paints, fillers for resins, rubbers, and the like. Another object of the present invention is to provide a method of producing the abovementioned cationic hollow crosslinked polymer particles with excellent characteristics in a stable manner. The hollow crosslinked polymer particles of the present invention are characterized in that (I) the zeta potential as measured in an aqueous medium of pH 2 to 9 is in the range of +5 to +100 mV, (II) the volume hollowness is in the range of 1 to 80%, and (III) the average particle diameter is in the range of 0.03 to 10 &mgr;m. This hollow crosslinked polymer particles are produced by a method that (a) 1 to 99.99 weight % of a crosslinking monomer, (b) 0.01 to 15 weight % of a cationic monomer, and (c) 0 to 98.99 weight % of a copolymerizable monomer that is non-crosslinking and nonionic (the total amount of the monomers being 100 weight %) are polymerized under the presence of polymer particles that are swellable by at least one of the above monomers. This hollow crosslinked cationic polymer particles are utilized for paint composition, cationic electrodeposition paint composition, resin composition, filled paper, paper coating composition, and coated paper, and the like.

摘要翻译： 本发明的目的是提供在宽pH范围内保持阳离子性能的阳离子中空交联聚合物颗粒，具有足够的强度，并且有利于用于填充纸，涂料用颜料，涂料用添加剂，树脂填料 ，橡胶等。 本发明的另一个目的是提供以稳定的方式制备具有优异特性的上述阳离子中空交联聚合物颗粒的方法。 本发明的中空交联聚合物颗粒的特征在于（I）在pH 2至9的水性介质中测得的ζ电位在+5至+ 100mV的范围内，（II）体积空心度在 1〜80％的范围，（III）的平均粒径为0.03〜10μm的范围。 该中空交联聚合物颗粒通过以下方法制备：（a）1至99.99重量％的交联单体，（b）0.01至15重量％的阳离子单体，和（c）0至98.99重量％的可共聚单体 即非交联和非离子（单体的总量为100重量％）在由至少一种上述单体可溶胀的聚合物颗粒的存在下聚合。 该中空交联阳离子聚合物颗粒用于涂料组合物，阳离子电沉积漆组合物，树脂组合物，填充纸，纸涂层组合物和涂布纸等。