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    System for optimizing the display and rendering of digital images for digital mastering
    3.
    发明授权
    System for optimizing the display and rendering of digital images for digital mastering 有权

    公开(公告)号：US07053927B2

    公开(公告)日：2006-05-30

    申请号：US09797901

    申请日：2001-03-02

    申请人： David S. Jones ,  Mitchell J. Bogdanowicz ,  Bradley W. VanSant ,  Enid Muniz ,  Charles P. Hagmaier ,  Carlo V. Hume

    发明人： David S. Jones ,  Mitchell J. Bogdanowicz ,  Bradley W. VanSant ,  Enid Muniz ,  Charles P. Hagmaier ,  Carlo V. Hume

    IPC分类号： H04N3/36

    CPC分类号： H04N3/36 ,  H04N1/60 ,  H04N1/6011 ,  H04N1/603 ,  H04N9/11

    摘要： A digital mastering system for processing digital image signals originating from scanned motion picture film includes a film scanner for scanning motion picture film and generating a stream of digital image signals corresponding to motion picture images, a color grading channel that pre-visualizes a certain “look” that can be applied to the digital image signals and a digital rendering channel that renders the digital image signals pre-visualized for a certain “look” into a digital master. The “look” includes the appearances produced by either a standard motion picture print film and/or adjustments applied to a standard appearance to obtain a creative effect. The color grading channel includes a parameter generator for storing parameters for a plurality of “looks”, a digital color grading processor for applying one or more selected parameters to impart a pre-visualized “look” to the digital image signals and a display device capable of reproducing the color graded signals. The digital rendering channel includes a digital rendering processor for applying one or more of the parameters selected by the parameter generator to the digital image signals in order to impart the rendered “look” into the digital image signals and a digital mastering device for producing a digital master from the rendered digital image signals.

    Conjugates comprising galactose &agr;1,3 galactosyl epitopes and methods of using same
    4.
    发明授权
    Conjugates comprising galactose &agr;1,3 galactosyl epitopes and methods of using same 失效
    包含半乳糖α1,3半乳糖基表位的缀合物及其使用方法

    公开(公告)号：US06399578B1

    公开(公告)日：2002-06-04

    申请号：US09457913

    申请日：1999-12-08

    申请人： Richard M. Jack ,  David S. Jones ,  Lin Yu

    发明人： Richard M. Jack ,  David S. Jones ,  Lin Yu

    IPC分类号： A01N4304

    CPC分类号： C07H15/26 ,  A61K47/54 ,  A61K47/545 ,  C07H15/08 ,  C07H15/18

    摘要： This invention provides conjugates useful for xenotransplantation which comprise a galactose &agr;1,3 galactosyl (&agr;Gal) epitope conjugated to a valency platform molecule, preferably a chemically defined valency platform molecule which allows precise valency. The invention also provides compositions comprising these conjugates, and methods (such as methods for inducing tolerance) using these conjugates and compositions.

    摘要翻译： 本发明提供了可用于异种移植的缀合物，其包含与价态平台分子缀合的半乳糖α1,3半乳糖基（αGal）表位，优选化学定义的价态平台分子，其允许精确的化合价。 本发明还提供包含这些缀合物的组合物，以及使用这些缀合物和组合物的方法（例如诱导耐受性的方法）。

    Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides
    5.
    发明授权
    Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides 失效
    用于在寡核苷酸的5'末端提供官能团的改性磷中间体

    公开(公告)号：US5874552A

    公开(公告)日：1999-02-23

    申请号：US436100

    申请日：1995-05-08

    申请人： David S. Jones ,  John P. Hachmann ,  Michael J. Conrad ,  Stephen Coutts ,  Douglas Alan Livingston

    发明人： David S. Jones ,  John P. Hachmann ,  Michael J. Conrad ,  Stephen Coutts ,  Douglas Alan Livingston

    IPC分类号： A61K39/35 ,  A61K47/48 ,  C07C323/12 ,  C07D317/20 ,  C07F9/24 ,  C07F9/655 ,  C07H21/00 ,  C07H19/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07H21/00 ,  A61K39/35 ,  A61K47/48315 ,  C07C323/12 ,  C07D317/20 ,  C07F9/2408 ,  C07F9/65515 ,  A61K2039/6093 ,  Y02P20/55

    摘要： Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R.sup.1 and R.sup.2 are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined together to form with the nitrogen atom a cyclic structure of 4-7 carbon atoms and 0 to 1 annular chalcogen atoms of atomic number 8 to 16, G is a hydrocarbylene group of 1 to 20 carbon atoms and Z is a hydroxy-protected vicinal diol group bound to G by one of the vicinal diol carbon atoms or a disulfide group and bound to G by one of the sulfur atoms of the disulfide group, with the proviso that G is of at least 4 carbon atoms when Z is said disulfide group are used in conventional automated oligonucleotide synthesis to introduce a functional aldehyde or thiol group on the 5' end of the oligonucleotide to thereby provide a reactive site on the oligonucleotide that may be used to conjugate the oligonucleotide to molecules that contain a free amino group or an electrophilic center reactive with a thiol group.

    摘要翻译： 其中R为碱不稳定保护基的式（ⅩⅥ）的亚磷酰胺，R 1和R 2分别为1至6个碳原子的烷基，3至8个碳原子的环烷基或6至20个碳原子的芳基或连接在一起 与氮原子一起形成原子数为8〜16的4-7个碳原子和0〜1个环状硫族原子的环状结构，G为碳原子数1〜20的亚烃基，Z为羟基保护的邻二醇基 通过邻位二醇碳原子之一或二硫键与G结合，并且通过二硫基的硫原子之一与G结合，条件是当Z是所述二硫基时，G至少为4个碳原子 在常规的自动化寡核苷酸合成中，在寡核苷酸的5'末端引入功能性醛或硫醇基团，从而在寡核苷酸上提供可用于将寡核苷酸与含有游离氨基或电离子的分子缀合的反应性位点 与硫醇基反应的中间体。

    EVENT AND DATA MANAGEMENT SYSTEM AND METHOD
    10.
    发明申请
    EVENT AND DATA MANAGEMENT SYSTEM AND METHOD 有权
    事件和数据管理系统及方法

    公开(公告)号：US20100303020A1

    公开(公告)日：2010-12-02

    申请号：US12854000

    申请日：2010-08-10

    申请人： David S. Jones

    发明人： David S. Jones

    IPC分类号： H04W4/00 ,  G06F15/16 ,  H04M3/00

    CPC分类号： H04L51/18 ,  G06Q10/06311 ,  H04L47/10 ,  H04L51/30

    摘要： A method for transferring data based on an event function is provided. The method includes receiving an event function from an event initiator. The event function is distributed to one or more destinations associated with event performers. A response message is received as a function of destination and time. It is determined whether the time is less than or equal to a limit time, and it is further determined whether an event parameter is greater than or equal to an event constant if the time is less than or equal to the limit time. Data is transferred from a data origination system accessible by the event initiator to a data destination system accessible by the event performer if the event parameter is greater than or equal to the event constant and if the time is less than or equal to the limit time.

    摘要翻译： 提供了一种基于事件功能传输数据的方法。 该方法包括从事件发起者接收事件功能。 事件功能被分发到与事件执行者相关联的一个或多个目的地。 作为目的地和时间的函数接收响应消息。 确定时间是否小于或等于限制时间，并且如果时间小于或等于限制时间，则进一步确定事件参数是否大于或等于事件常数。 如果事件参数大于或等于事件常数，并且如果时间小于等于限制时间，则数据可以由事件发起者可访问的数据发起系统传送到事件执行者可访问的数据目标系统。