The invention discloses a pipeline route fixing device. The pipeline route fixing device comprises a fixed part and a movable part; the movable part is movably fixed on the fixed part, wherein the fixed part comprises a bottom plate and L-shaped plates; two L-shaped plates are arranged; vertical parts of the two L-shaped plates are symmetrically arranged on the bottom plate; horizontal parts of the two L-shaped plates oppositely extend; a plurality of open grooves are formed in the horizontal parts of the two L-shaped plates in the length direction in a spaced manner; the movable part comprises a base plate and a fastener; the fastener is fixed on the base plate; and first clamping structures which form clamping fit with the open grooves are arranged on the two opposite sides of the base plate. Compared with the prior art, the pipeline route fixing device has the advantages that the mounting position of the movable part on the fixed part can be changed according to the fixing positionsof the first clamping structures in the open grooves by arranging the first clamping structures and the plurality of open grooves matched with the first clamping structures; the fixing mode is flexible; and the universality is stronger.