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公开(公告)号：US12092608B2
公开(公告)日：2024-09-17
申请号：US17792170
申请日：2020-03-12
申请人： SHIMADZU CORPORATION
发明人： Hidenori Takahashi
IPC分类号： H01J49/14 , G01N27/623 , G01N27/626
CPC分类号： G01N27/623 , G01N27/626 , H01J49/14
摘要： An ion analysis device 1 configured to generate and analyze product ions from precursor ions derived from a sample component includes: a reaction chamber 132 into which the precursor ions are introduced; a radical emitter 134 made of a predetermined kind of metal and disposed in the reaction chamber or a space communicating with the reaction chamber, at least a part of a surface of the radical emitter being oxidized or nitrided; a heating unit 20 configured to heat the radical emitter to a predetermined temperature; and separation detection units 135 and 136 configured to separate and detect, according to at least one of a mass-to-charge ratio and an ion mobility, product ions generated from the precursor ions by a reaction with radicals emitted from the radical emitter heated to the predetermined temperature.
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公开(公告)号：US12068147B2
公开(公告)日：2024-08-20
申请号：US17611292
申请日：2020-05-15
发明人： Paul Scheier , Felix Laimer , Lorenz Kranabetter , Fabio Zappa , Michael Renzler , Lukas Thiefenthaler , Simon Albertini , Paul Martini , Siegfried Kollotzek
CPC分类号： H01J49/147 , H01J49/0054 , H01J49/4215
摘要： Method for producing multiply-charged helium nanodroplets and charged dopant clusters and nanoparticles out of the helium nanodroplets, the method comprising: •producing neutral helium nanodroplets in a cold head (1) via expansion of a pressurized, pre-cooled, supersonic helium beam of high purity through a nozzle (3) into high vacuum with a base pressure under operation preferably below 20 mPa, •ionizing the helium nanodroplets by electron impact (15), wherein the electron impact (15) leads to multiply-charged helium nanodroplets, •doping the charged helium nanodroplets with dopant vapor in the pickup cell (19), wherein the doped nanodroplets form cluster ions with the initial charges acting as seeds, wherein the size of the nanoparticles can vary from a few atoms up to 105 atoms by arranging the size of the neutral helium nanodroplets, the charge of the helium nanodroplets and the density of dopant vapor in the pickup cell (19).
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公开(公告)号：US20240170271A1
公开(公告)日：2024-05-23
申请号：US18552685
申请日：2022-03-30
CPC分类号： H01J49/0404 , H01J49/0431 , H01J49/145 , H01J49/165
摘要： A method of analyzing a liquid with a mass analysis device having a bubble generating interface (BGI) and a removal conduit includes aspirating a sample into the removal conduit at an aspira-tion pressure. Concurrently with aspirating the sample at least one operational condition of the BGI is controlled to generate a plurality of bubbles in the sample. Concurrently with aspirating the sample the plurality of bubbles are aspirated into the removal conduit. The sample and the plurality of bubbles are analyzed with the mass analysis device to generate a signal.
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公开(公告)号：US20240153753A1
公开(公告)日：2024-05-09
申请号：US18382570
申请日：2023-10-23
申请人： Inficon Inc.
发明人： Nigel Sousou
CPC分类号： H01J49/147 , H01J49/0031 , H01J49/0054 , H01J49/0072
摘要： An atmospheric pressure electron impact ionization mass spectrometer system includes an atmospheric pressure ionization component operated at an atmospheric pressure. An electron impact ionization mass spectrometer includes an electron ionization source. An atmospheric pressure interface operates below about 10 Torr. The atmospheric pressure interface includes a source block to focus a plurality of molecules and ions from the atmospheric pressure ionization component at the atmospheric pressure into the electron ionization source which operates at a pressure below about 10−3 Torr.
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公开(公告)号：US20240038522A1
公开(公告)日：2024-02-01
申请号：US18274597
申请日：2022-03-15
申请人： INFICON, Inc.
发明人： Norbert Mueller , Daniel Vanoni , Jochen Wagner
CPC分类号： H01J49/147 , H01J49/0031 , H01J49/145 , G01N30/7206 , G01N27/64
摘要： A wide-range ion source for a mass spectrometer comprises a first portion and a second portion that is positioned downstream of the first portion. The first portion includes an anode and a first filament that is positioned proximate the anode and secured in place relative to the anode. The first filament is exposed to a pressure of a process chamber. A first electron repeller has at least a partially circular shape. The second portion includes a tubular anode, a second filament surrounding the tubular anode, an extraction lens defining an opening and a focus lens to conduct ions into a volume.
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公开(公告)号：US11852636B2
公开(公告)日：2023-12-26
申请号：US18091726
申请日：2022-12-30
发明人： Brett Holmquist , Nigel Clarke
CPC分类号： G01N33/82 , G01N30/7233 , H01J49/004 , H01J49/145 , G01N2030/009 , G01N2030/027 , G01N2030/8813
摘要： The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号：US11848186B2
公开(公告)日：2023-12-19
申请号：US17057724
申请日：2019-05-31
申请人： Micromass UK Limited
发明人： Alastair Booth , Alvin Chua , Carl Chen , Marcus Dawber , Enchen Guo , William Ngo , Dennis Ong , Richard Tyldesley-Worster , Arvind Rangan
CPC分类号： H01J49/147 , H01J27/024 , H01J27/205 , H01J49/26
摘要： An inner source assembly for a mass spectrometer, the assembly comprising: a base; and a volume housing removably connectable to the base for retaining a repeller assembly therebetween, wherein one of the base and volume housing comprises at least two protrusions and the other of the volume housing and base comprises at least two corresponding slots to receive and retain said protrusions, wherein the protrusions are dissimilar to one another and/or the slots are dissimilar to one another.
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公开(公告)号：US11817300B2
公开(公告)日：2023-11-14
申请号：US16557302
申请日：2019-08-30
申请人： Micromass UK Limited
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/0045 , H01J49/14 , H01J49/26
摘要： A method of encoding a parent or precursor ion beam to aid product ion assignment is disclosed. According to an embodiment the energy of parent ions entering a collision cell 3 is progressively increased. Different species of parent ions fragment at different collision energies. Fragment ion intensity profiles are matched with parent ion intensity profiles to correlate fragment ions with corresponding parent ions.
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公开(公告)号：US11784035B2
公开(公告)日：2023-10-10
申请号：US18101265
申请日：2023-01-25
发明人： Robert Graham Cooks
CPC分类号： H01J49/165 , H01J49/0013
摘要： The invention generally relates to systems and methods for conducting reactions and screening for reaction products.
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公开(公告)号：US11735408B2
公开(公告)日：2023-08-22
申请号：US17424210
申请日：2019-01-23
申请人： SHIMADZU CORPORATION
发明人： Hidenori Takahashi
CPC分类号： H01J49/14 , H01J49/0422
摘要： An ion analyzer that generates and analyzes product ions by irradiating precursor ions derived from a sample component with radicals, the ion analyzer including: a reaction chamber (2; 833) into which the precursor ions are introduced; a radical generation unit (5) configured to generate radicals from a first material gas; a metastable particle generation unit (5) configured to generate metastable particles from a second material gas; a radical introduction unit (5) configured to mix the radical and the metastable particles and introduce the mixture into the reaction chamber (2; 833); and an ion detection unit (4; 835) configured to detect product ions generated from the precursor ions by a reaction with the radicals.
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