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公开(公告)号：US20240310252A1
公开(公告)日：2024-09-19
申请号：US18442730
申请日：2024-02-15
申请人： Clarapath, Inc.
发明人： Baris Yagci , Eric Feinstein , Partha P. Mitra , Janak Sewkarran , Cong Zhang , Robert Shusko
CPC分类号： G01N1/06 , B01L3/508 , G01N1/36 , B01L2300/043 , B01L2300/046 , B01L2300/069 , B01L2300/0809 , G01N2001/065 , G01N2001/315 , G01N2001/366
摘要： There is provided an automated system for preparing tissue samples that comprises one or more microtomes, a hydration system, and a processor, the processor being programmed to initiate facing, by one or more microtomes, of a first tissue block comprising a first tissue sample embedded in an embedding material, and cause the first tissue block to be hydrated by the hydration system for a first predetermined time, and initiate facing, by one or more microtomes, of a second tissue block while the first tissue block is being hydrated, the second tissue block comprising a second tissue sample embedded in an embedding material, and cause the second tissue block to be hydrated by the hydration system for a second predetermined time, and to initiate the one or more microtomes to begin sectioning of the first tissue block while the second tissue block is being hydrated.
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公开(公告)号：US12078578B2
公开(公告)日：2024-09-03
申请号：US18211046
申请日：2023-06-16
发明人： Bela Suki , Jae Hun Kim , Joseph Hall , Ramaswamy Krishnan , Niccole Schaible
CPC分类号： G01N1/06 , G01N1/312 , G01N3/08 , G01N35/00009 , G01N2035/00019
摘要： Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.
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公开(公告)号：US20240241018A1
公开(公告)日：2024-07-18
申请号：US18430467
申请日：2024-02-01
发明人： Yuji Ishitsuka , Zhenmin Hong , Eli N. Glezer , Hu Cang , William Dempsey , Weiqiao Ding , Jaekyung Koh , Mohammad Vatankhah Varnosfaderani
CPC分类号： G01N1/286 , G01N1/06 , G01N2001/288
摘要： Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.
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公开(公告)号：US11898945B2
公开(公告)日：2024-02-13
申请号：US17025937
申请日：2020-09-18
发明人： Lawrence H. Dirks
CPC分类号： G01N1/06 , A61B10/0266 , B26D5/086 , G01N2001/061 , G01N2001/065
摘要： A microtome blade guard including a first arm operable to be coupled to a first side of a cutting mechanism of a microtome; a second arm operable to be coupled to a second side of a cutting mechanism; a lateral support member disposed between the first arm and the second arm; and a staff coupled to the lateral support member and operable to extend therefrom to engage a blade positioned in the blade slot. A microtome including a blade guard and a method including placing a blade in a blade slot of a blade block of a microtome; engaging the blade with a staff coupled to a blade guard that is coupled to the blade block; and moving the blade with the staff.
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公开(公告)号：US11872565B2
公开(公告)日：2024-01-16
申请号：US17970042
申请日：2022-10-20
IPC分类号： G01N1/06 , B01L9/00 , G01N33/483 , G01N1/36
CPC分类号： B01L9/52 , G01N1/06 , G01N1/36 , G01N33/4833
摘要： A method for preparing one or more biopsy tissue samples for histological examination includes positioning a tissue sample in a tissue cassette, closing a peripheral portion of a frame including a cassette lid, and moving the lid and the tissue cassette from a first position to a second position. The tissue cassette is coupled to a frame by a frame-cassette connector and moving the lid and the tissue cassette from the first position to the second position includes breaking the frame-cassette connector. The tissue cassette has a recess including at least one side wall and a bottom wall and is formed of a first material that can be successfully sectioned in a microtome. In the second position, the bottom wall and at least a portion of the side wall extend downwardly beyond a bottom edge of the frame for sectioning in the microtome.
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公开(公告)号：US20230324259A1
公开(公告)日：2023-10-12
申请号：US18022289
申请日：2020-09-03
发明人： ZheGuang FAN , HongJian TAO , Song JIN , Alice ZHANG
CPC分类号： G01N1/06 , B26D7/2614 , G01N2001/061
摘要： A microtome includes a blade; and a knife holder. The blade has a cutting edge configured to section a specimen block. The knife holder includes a base, a pressure plate and a frame. The pressure plate is connected to the base, and the pressure plate is adjustable relative to the base to clamp the blade between base and the pressure plate. The frame includes at least one limb and a bridge extending from the at least one limb parallel to the cutting edge. The bridge is proximate the cutting edge, the bridge and the blade cooperatively define a first gap therebetween, and the bridge and the pressure plate cooperatively define a second gap therebetween.
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公开(公告)号：US11733131B2
公开(公告)日：2023-08-22
申请号：US16609074
申请日：2018-04-27
发明人： Shinobu Masuda , Ryohei Suzuki , Yuriko Kitano
摘要： The present invention is to provide a tissue slice selection method and an embedded block-preparing cassette which are capable of suppressing occurrence of errors in inspection results. The present invention makes it possible to suppress the occurrence of errors in inspection results by including: an embedded block-preparing process of preparing an embedded block by embedding both a biological tissue fragment and a standard substance in the same embedding agent; an embedded tissue slice preparing step of slicing the embedded block to prepare a sheet-like embedded tissue slice having a tissue slice and standard substance slices appearing on a surface thereof; and a tissue slice selecting step of selecting the tissue slice to be inspected, based on a light signal from the standard substance slice.
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公开(公告)号：US20230256641A1
公开(公告)日：2023-08-17
申请号：US17773493
申请日：2019-10-30
发明人： Zheguang FAN , Hongjian TAO
CPC分类号： B26D7/2614 , G01N1/06 , G01N2001/061 , G01N2001/066
摘要： A blade moving device includes: a support base; a linear bushing arranged in the support base; a moving block received in the support base and movably fitted over the linear bushing; a touch connector connected to the moving block and configured to move along with the moving block; and a blade box connected to the support base and configured to receive a blade therein. The touch connector is further configured to touch and push the blade to move out of the blade box when moving along with the moving block.
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9.发明公开公开(公告)号：US20230243722A1
公开(公告)日：2023-08-03
申请号：US17773160
申请日：2019-10-30
发明人： Zheguang FAN , Haixia ZHANG
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , G01N2001/061
摘要： A blade roller device (100) includes a first blade roll unit (110), a second blade roll unit (120) spaced apart from the first blade roll unit (110), and a first rotate lever (130). The first blade roll unit (110) includes a first slewing mechanism (111) and a first blade roll (112) wound upon the first slewing mechanism (111). The second blade roll unit (120) includes a second slewing mechanism (121) coupled to the first rotate lever (130) and a second blade roll (122) formed by pulling a segment of the first blade roll (112) to the second slewing mechanism (121) and winding the segment of the first blade roll (112) upon the second slewing mechanism (121). A rotation of the first rotate lever (130) in a first direction is capable of pulling the segment of first blade roll (112) to the second slewing mechanism (121).
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公开(公告)号：US20230221222A1
公开(公告)日：2023-07-13
申请号：US17992894
申请日：2022-11-22
申请人： Clarapath, Inc.
发明人： Partha P. Mitra , Aaron Ames , Baris Yagci , Robert Shusko , Robert Chen
CPC分类号： G01N1/312 , G01N1/06 , G01N2001/315 , G01N2001/061
摘要： A microtomy system includes a tissue chuck configured to accept a tissue block and a microtome blade configured to remove one or more tissue sections from the tissue block, the microtome blade being axially offset from the tissue chuck along a horizontal axis, where the microtome blade and the tissue chuck are axially displaceable relative to one another along the horizontal axis. The system also includes a control system configured to receive information indicative of a relative axial location of the microtome blade to the tissue chuck along the horizontal axis, and to use a control loop to control the relative axial location of the microtome blade to the tissue chuck such that the one or more tissue sections have a desired thickness.
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